Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI

• Published in: Magnetic resonance in medicine Vol. 47; no. 1; pp. 149 - 159
• Main Authors: Steinman, David A., Thomas, Jonathan B., Ladak, Hanif M., Milner, Jaques S., Rutt, Brian K., Spence, J. David
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.01.2002; Williams & Wilkins
• Subjects: Adult; atherosclerosis; Biological and medical sciences; Cardiovascular system; Carotid Arteries - anatomy & histology; carotid artery bifurcation; Cerebrovascular Circulation - physiology; computational fluid dynamics; Female; Hemodynamics; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Intracranial Arteriosclerosis - pathology; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Radiodiagnosis. Nmr imagery. Nmr spectrometry; wall shear stress; Human; Regional blood flow; Carotid bifurcation; Fluid dynamics; Cardiovascular disease; Exploration; Nuclear magnetic resonance imaging; Vascular disease; Thickness; Atherosclerotic plaque; Atherosclerosis; Medical imagery; Evolution; Vascular wall
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.10025

A thorough understanding of the relationship between local hemodynamics and plaque progression has been hindered by an inability to prospectively monitor these factors in vivo in humans. In this study a novel approach for noninvasively reconstructing artery wall thickness and local hemodynamics at the human carotid bifurcation is presented. Three‐dimensional (3D) models of the lumen and wall boundaries, from which wall thickness can be measured, were reconstructed from black‐blood magnetic resonance imaging (MRI). Along with time‐varying inlet/outlet flow rates measured via phase contrast (PC) MRI, the lumen boundary was used as input for computational fluid dynamic (CFD) simulation of the subject‐specific flow patterns and wall shear stresses (WSSs). Results from a 59‐year‐old subject with early, asymptomatic carotid artery disease show good agreement between simulated and measured velocities, and demonstrate a correspondence between wall thickening and low and oscillating shear at the carotid bulb. High shear at the distal internal carotid artery (ICA) was also colocalized with higher WSS; however, a quantitative general relationship between WSS and wall thickness was not found. Similar results were obtained from a 23‐year‐old normal subject. These findings represent the first direct comparison of hemodynamic variables and wall thickness at the carotid bifurcation of human subjects. The noninvasive nature of this image‐based modeling approach makes it ideal for carrying out future prospective studies of hemodynamics and plaque development or progression in otherwise healthy subjects.