Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts

• Published in: Behavioural pharmacology Vol. 24; no. 5-6; p. 504
• Main Authors: Comer, Sandra D, Metz, Verena E, Cooper, Ziva D, Kowalczyk, William J, Jones, Jermaine D, Sullivan, Maria A, Manubay, Jeanne M, Vosburg, Suzanne K, Smith, Mary E, Peyser, Deena, Saccone, Phillip A
• Format: Journal Article
• Language: English
• Published: England 01.09.2013
• Subjects: Administration, Oral; Adult; Analgesics, Opioid - administration & dosage; Buprenorphine - therapeutic use; Choice Behavior - drug effects; Choice Behavior - physiology; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; In Vitro Techniques; Male; Middle Aged; Morphine - administration & dosage; Narcotic Antagonists - therapeutic use; Opioid-Related Disorders - drug therapy; Opioid-Related Disorders - psychology; Oxycodone - administration & dosage; Pain Measurement; Pupil - drug effects; Pupil - physiology; Reward; Self Administration; Surveys and Questionnaires; Time Factors; Token Economy; Young Adult
• ISSN: 1473-5849
• DOI: 10.1097/FBP.0b013e328363d1c4

This double-blind, placebo-controlled study investigated the effects of oral morphine (0, 45, 135 mg/70 kg) and oral oxycodone (0, 15, 45 mg/70 kg) on buprenorphine-maintained opioid addicts. As a 3: 1 morphine : oxycodone oral dose ratio yielded equivalent subjective and physiological effects in no...