Effect of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of apixaban - Chang, Ming; Yu, Zhigang; Shenker, Andrew; Wang, Jessie; Pursley, Janice; Byon, Wonkyung; Boyd, Rebecca A; LaCreta, Frank; Frost, Charles E (Journal of clinical pharmacology, 2016)
Keywords: Adult; Aged; Aged, 80 and over; Area Under Curve; Creatinine - analysis; Factor Xa - analysis; Factor Xa Inhibitors - adverse effects; Factor Xa Inhibitors - blood; Factor Xa Inhibitors - pharmacokinetics; Factor Xa Inhibitors - pharmacology; Female; Humans; International Normalized Ratio; Male; Middle Aged; Pyrazoles - adverse effects; Pyrazoles - blood; Pyrazoles - pharmacokinetics; Pyrazoles - pharmacology; Pyridones - adverse effects; Pyridones - blood; Pyridones - pharmacokinetics; Pyridones - pharmacology; Renal Insufficiency - metabolism; pharmacokinetics; anticoagulant; apixaban; pharmacodynamics; renal impairment