Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels

• Published in: Circulation. Cardiovascular genetics Vol. 10; no. 4; p. e001720
• Main Authors: Bazan, Hernan A., Hatfield, Samuel A., Brug, Aaron, Brooks, Ashton J., Lightell, Daniel J., Woods, T. Cooper
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.08.2017
• Subjects: Aged; Area Under Curve; Arteriosclerosis; Biomarkers; Biomarkers - blood; Cerebrovascular system; Circular RNA; Endarterectomy, Carotid; Female; Humans; Ischemia; Likelihood Functions; Male; MicroRNAs - blood; Middle Aged; Plaque, Atherosclerotic - diagnosis; Plaque, Atherosclerotic - pathology; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; RNA - blood; RNA - isolation & purification; RNA - metabolism; ROC Curve; Rupture; Serum levels; Stroke; Stroke - diagnosis; Stroke - pathology; Stroke - surgery; microRNAs; RNA, untranslated; stroke; endarterectomy, carotid; ischemia

BACKGROUND—Atherosclerotic plaque rupture is accompanied by an acute decrease in the carotid plaque expression of micro-RNAs (miRs)-221 and miR-222. Circular RNA (circR)-284 is a potential inhibitor of miR-221/miR-222 activity. We aimed to determine whether changes in the serum levels of these nonco...