Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

• Published in: Differentiation (London) Vol. 73; no. 8; pp. 397 - 405
• Main Authors: Barnfield, Paul C., Zhang, Xiaoyun, Thanabalasingham, Vijitha, Yoshida, Minoru, Hui, Chi-chung
• Format: Journal Article
• Language: English
• Published: Malden, USA Elsevier B.V 01.10.2005; Blackwell Publishing Inc
• Subjects: Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Cell Nucleus - metabolism; Exportin 1 Protein; Gene Expression Regulation; Genes, Suppressor; Gli proteins; Hedgehog; Karyopherins - metabolism; Karyopherins - physiology; Kruppel-Like Transcription Factors - metabolism; Mice; nuclear export signal; Oncogene Proteins - metabolism; Point Mutation; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, Cytoplasmic and Nuclear - physiology; Repressor Proteins - metabolism; Repressor Proteins - physiology; Suppressor of fused; Trans-Activators; Transcription Factors - metabolism; Transcriptional Activation; transcriptional inactivation; Transfection; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2; nuclear export signal; Hedgehog; transcriptional inactivation; Suppressor of fused; Gli proteins

During animal development, the Hedgehog (Hh) signal transduction pathway plays critical roles in cell fate determination and tissue patterning. In humans, aberrant Hh signaling has been linked to several genetic disorders and cancers. Binding of Hh to its receptor initiates a signaling cascade, whic...