Altered Hematopoietic Stem Cell and Osteoclast Precursor Frequency in Cathepsin K Null Mice

• Published in: Journal of cellular biochemistry Vol. 115; no. 8; pp. 1449 - 1457
• Main Authors: Jacome-Galarza, Christian, Soung, Do Yu, Adapala, Naga Suresh, Pickarski, Maureen, Sanjay, Archana, Duong, Le T., Lorenzo, Joseph A., Drissi, Hicham
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.08.2014; Wiley Subscription Services, Inc
• Subjects: Animals; Bone Resorption - genetics; Bone Resorption - pathology; CATHEPSIN K; Cathepsin K - genetics; Cathepsin K - metabolism; Fracture Healing - genetics; HEMATOPOIESIS; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - pathology; Mice; Mice, Knockout; OSTEOCLAST PRECURSORS; Osteoclasts - metabolism; Osteoclasts - pathology; Osteogenesis; OSTEOPETROSIS; Osteopetrosis - genetics; Osteopetrosis - pathology; CATHEPSIN K; HEMATOPOIESIS; OSTEOPETROSIS; OSTEOCLAST PRECURSORS

ABSTRACT Cathepsin K (CatK) is a lysosomal cysteine protease necessary for bone resorption by osteoclasts (OCs), which originate from myeloid hematopoietic precursors. CatK‐deficient (CatK−/−) mice show osteopetrosis due to defective resorption by OCs, which are increased in number in these mice. We...