Advanced Method for Evaluation of Gastric Cancer Risk By Serum Markers: Determination of True Low-Risk Subjects for Gastric Neoplasm

• Published in: Helicobacter (Cambridge, Mass.) Vol. 19; no. 1; pp. 1 - 8
• Main Authors: Boda, Tomoyuki, Ito, Masanori, Yoshihara, Masaharu, Kitamura, Yoko, Matsuo, Taiji, Oka, Shiro, Tanaka, Shinji, Chayama, Kazuaki
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2014; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Atrophy - pathology; Biomarkers, Tumor - blood; Endoscopy, Gastrointestinal; Female; gastric cancer; Gastric Mucosa - pathology; gastrin; Health risks; Helicobacter; Helicobacter Infections - complications; Helicobacter pylori; Helicobacter pylori - isolation & purification; Histocytochemistry; Humans; Immunohistochemistry; Male; Mass Screening - methods; Microscopy; Middle Aged; pepsinogen; Pepsinogen A - blood; Risk Assessment; risk management; Sensitivity and Specificity; Stomach Neoplasms - diagnosis; risk management; Helicobacter pylori; gastric cancer; gastrin; pepsinogen

Background Patients with negative anti‐Helicobacter pylori antibody titer and high pepsinogen (PG) level (group A) are regarded as having a low risk for gastric cancer. However, gastric cancer cases are occasionally observed in this group. We aimed to elucidate the clinical features of gastric neopl...