Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension

• Published in: Respiratory research Vol. 26; no. 1; pp. 148 - 19
• Main Authors: Harper, Rebecca L., Zhou, Xin, Marciano, David P., Cao, Aiqin, Wang, Lingli, Chen, Guibin, Adil, Mir S., Zhou, Wenyu, Maguire, Peter, Deivanayagam, Shanthi, Yu, Quan, Viswanathan, Vignesh, Yang, Dan, Martin, Marcy, Isobe, Sarasa, Otsuki, Shoichiro, Burgess, Jordan, Inglis, Audrey, Kelley, Devon, del Rosario, Patricia A., Hsi, Andrew, Haddad, Francois, Zamanian, Roham T., Boehm, Manfred, Snyder, Michael P., Rabinovitch, Marlene
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.04.2025; BioMed Central; BMC
• Subjects: Adult; Animals; BMPR2; Bone Morphogenetic Protein Receptors, Type II - genetics; CD14; Female; Health aspects; Humans; Macrophage; Male; Medical research; Medicine, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocyte; Monocytes; Monocytes - metabolism; Monocytes - pathology; Physiological aspects; Pulmonary arterial hypertension; Pulmonary Arterial Hypertension - blood; Pulmonary Arterial Hypertension - genetics; Pulmonary Arterial Hypertension - pathology; Pulmonary hypertension; STAT1; United States; Pulmonary arterial hypertension; BMPR2; CD14; Monocyte; STAT1; Macrophage

It is well-established that patients with pulmonary arterial hypertension (PAH) exhibit increased recruitment of circulating monocytes to their pulmonary arteries. However, it remains unclear whether these monocytes have intrinsic abnormalities that contribute to their recruitment and to PAH pathoge...