The Intermediate Filament Architecture as Determined by X-Ray Diffraction Modeling of Hard α-Keratin

• Published in: Biophysical journal Vol. 86; no. 6; pp. 3893 - 3904
• Main Authors: Er Rafik, Mériem, Doucet, Jean, Briki, Fatma
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2004; Biophysical Society
• Subjects: Animals; Biological Physics; Desmin; Desmin - chemistry; Intermediate Filaments; Intermediate Filaments - chemistry; Keratins; Keratins - chemistry; Models, Molecular; Physics; Supramolecular Assemblies; Vimentin; Vimentin - chemistry; X-Ray Diffraction

Despite investigation since the 1950s, the molecular architecture of intermediate filaments has not yet been fully elucidated. Reliable information about the longitudinal organization of the molecules within the filaments and about the lateral interfilament packing is now available, which is not the...