A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled...
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Published in | Osteoarthritis and cartilage Vol. 13; no. 9; pp. 769 - 781 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.09.2005
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Subjects | |
Online Access | Get full text |
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Abstract | To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity.
Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity.
Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53–0.75] and hand [RR 0.81, 95% CI 0.73–0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18–1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32–0.94] and hip [IRR 0.64, 95% CI 0.48–0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35–1.20]. Females, particularly those ≥55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition.
The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA. |
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AbstractList | OBJECTIVETo resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity.METHODSStandard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity.RESULTSMales had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53-0.75] and hand [RR 0.81, 95% CI 0.73-0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18-1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32-0.94] and hip [IRR 0.64, 95% CI 0.48-0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35-1.20]. Females, particularly those > or = 55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition.CONCLUSIONSThe results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA. To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity. Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53–0.75] and hand [RR 0.81, 95% CI 0.73–0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18–1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32–0.94] and hip [IRR 0.64, 95% CI 0.48–0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35–1.20]. Females, particularly those ≥55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition. The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA. To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity. Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53-0.75] and hand [RR 0.81, 95% CI 0.73-0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18-1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32-0.94] and hip [IRR 0.64, 95% CI 0.48-0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35-1.20]. Females, particularly those > or = 55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition. The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA. |
Author | Jones, Graeme Fryer, Jayne L. Zhai, Guangju Hosmer, David Winzenberg, Tania M. Srikanth, Velandai K. |
Author_xml | – sequence: 1 givenname: Velandai K. surname: Srikanth fullname: Srikanth, Velandai K. email: velandai.srikanth@utas.edu.au organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia – sequence: 2 givenname: Jayne L. surname: Fryer fullname: Fryer, Jayne L. organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia – sequence: 3 givenname: Guangju surname: Zhai fullname: Zhai, Guangju organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia – sequence: 4 givenname: Tania M. surname: Winzenberg fullname: Winzenberg, Tania M. organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia – sequence: 5 givenname: David surname: Hosmer fullname: Hosmer, David organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia – sequence: 6 givenname: Graeme surname: Jones fullname: Jones, Graeme organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15978850$$D View this record in MEDLINE/PubMed |
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Snippet | To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and... OBJECTIVETo resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence... |
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SubjectTerms | Age Factors Aged Female Hand Joints Humans Incidence Joints - pathology Male Middle Aged Osteoarthritis Osteoarthritis - epidemiology Osteoarthritis - pathology Osteoarthritis, Knee - epidemiology Population-based Prevalence Regression Analysis Risk Factors Sex differences Sex Factors |
Title | A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis |
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