A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis

To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled...

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Published inOsteoarthritis and cartilage Vol. 13; no. 9; pp. 769 - 781
Main Authors Srikanth, Velandai K., Fryer, Jayne L., Zhai, Guangju, Winzenberg, Tania M., Hosmer, David, Jones, Graeme
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2005
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Abstract To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity. Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53–0.75] and hand [RR 0.81, 95% CI 0.73–0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18–1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32–0.94] and hip [IRR 0.64, 95% CI 0.48–0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35–1.20]. Females, particularly those ≥55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition. The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA.
AbstractList OBJECTIVETo resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity.METHODSStandard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity.RESULTSMales had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53-0.75] and hand [RR 0.81, 95% CI 0.73-0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18-1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32-0.94] and hip [IRR 0.64, 95% CI 0.48-0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35-1.20]. Females, particularly those > or = 55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition.CONCLUSIONSThe results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA.
To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity. Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53–0.75] and hand [RR 0.81, 95% CI 0.73–0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18–1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32–0.94] and hip [IRR 0.64, 95% CI 0.48–0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35–1.20]. Females, particularly those ≥55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition. The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA.
To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity. Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53-0.75] and hand [RR 0.81, 95% CI 0.73-0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18-1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32-0.94] and hip [IRR 0.64, 95% CI 0.48-0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35-1.20]. Females, particularly those > or = 55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition. The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA.
Author Jones, Graeme
Fryer, Jayne L.
Zhai, Guangju
Hosmer, David
Winzenberg, Tania M.
Srikanth, Velandai K.
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  surname: Srikanth
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  email: velandai.srikanth@utas.edu.au
  organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
– sequence: 2
  givenname: Jayne L.
  surname: Fryer
  fullname: Fryer, Jayne L.
  organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
– sequence: 3
  givenname: Guangju
  surname: Zhai
  fullname: Zhai, Guangju
  organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
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  givenname: Tania M.
  surname: Winzenberg
  fullname: Winzenberg, Tania M.
  organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
– sequence: 5
  givenname: David
  surname: Hosmer
  fullname: Hosmer, David
  organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
– sequence: 6
  givenname: Graeme
  surname: Jones
  fullname: Jones, Graeme
  organization: The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15978850$$D View this record in MEDLINE/PubMed
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Snippet To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and...
OBJECTIVETo resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence...
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SubjectTerms Age Factors
Aged
Female
Hand Joints
Humans
Incidence
Joints - pathology
Male
Middle Aged
Osteoarthritis
Osteoarthritis - epidemiology
Osteoarthritis - pathology
Osteoarthritis, Knee - epidemiology
Population-based
Prevalence
Regression Analysis
Risk Factors
Sex differences
Sex Factors
Title A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
URI https://dx.doi.org/10.1016/j.joca.2005.04.014
https://www.ncbi.nlm.nih.gov/pubmed/15978850
https://search.proquest.com/docview/68575568
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