Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia

• Published in: Journal of translational medicine Vol. 23; no. 1; pp. 542 - 19
• Main Authors: Guo, Shanshan, Bourova-Flin, Ekaterina, Rousseaux, Sophie, Chuffart, Florent, Peng, Lijun, Jing, Duohui, Mi, Jian-Qing, Khochbin, Saadi, Wang, Jin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.05.2025; BioMed Central; BMC
• Subjects: ABCB1 activation; Acute lymphocytic leukemia; Adult; ATP Binding Cassette Transporter, Subfamily B - metabolism; Cell Line, Tumor; Development and progression; Drug resistance; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Drug therapy; Female; Health aspects; Humans; Lipid accumulation; Lipid Metabolism; Male; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial activity; Physiological aspects; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology; T cells; T-cell acute lymphoblastic leukemia; China; Mitochondrial activity; Lipid accumulation; ABCB1 activation; Drug resistance; T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a relatively rare hematological malignancy, characterized by the uncontrolled proliferation of immature T lymphoblasts and associated with a generally unfavorable prognosis. Our previous research has demonstrated that decreased mitochondrial activity is...