Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia - Guo, Shanshan; Bourova-Flin, Ekaterina; Rousseaux, Sophie; Chuffart, Florent; Peng, Lijun; Jing, Duohui; Mi, Jian-Qing; Khochbin, Saadi; Wang, Jin (Journal of translational medicine, 2025)
Keywords: ABCB1 activation; Acute lymphocytic leukemia; Adult; ATP Binding Cassette Transporter, Subfamily B - metabolism; Cell Line, Tumor; Development and progression; Drug resistance; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Drug therapy; Female; Health aspects; Humans; Lipid accumulation; Lipid Metabolism; Male; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial activity; Physiological aspects; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology; T cells; T-cell acute lymphoblastic leukemia; China; Mitochondrial activity; Lipid accumulation; ABCB1 activation; Drug resistance; T-cell acute lymphoblastic leukemia