Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis

• Published in: Molecular human reproduction Vol. 13; no. 10; pp. 705 - 712
• Main Authors: Lardone, M.C., Parodi, D.A., Valdevenito, R., Ebensperger, M., Piottante, A., Madariaga, M., Smith, R., Pommer, R., Zambrano, N., Castro, A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2007; Oxford Publishing Limited (England)
• Subjects: Adult; AZF genes; Azoospermia - genetics; Azoospermia - pathology; Biological and medical sciences; Cell Cycle Proteins - genetics; DBY; DDX3Y; DEAD-box RNA Helicases - genetics; Deleted in Azoospermia 1 Protein; Embryology: invertebrates and vertebrates. Teratology; Fundamental and applied biological sciences. Psychology; Humans; Male; Middle Aged; Minor Histocompatibility Antigens; Nuclear Proteins - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-Binding Proteins - genetics; Spermatogenesis - genetics; spermatogenesis impairment; testicular transcripts; Testis - metabolism; Testis - pathology; DDX3Y; DBY; testicular transcripts; spermatogenesis impairment; AZF genes; Human; Messenger RNA; Gene; Spermatogenesis; Severe; Testicle; Male genital system

Y chromosome microdeletion is the most important genetic cause of impairment of spermatogenesis. Nevertheless, a significant proportion of patients with spermatogenic failure do not have this condition. This study investigated the expression level of AZF genes, DDX3Y (DBY), RBMY1, DAZ and TSPY in te...