Pulsed arterial spin labeling perfusion imaging at 3 T: estimating the number of subjects required in common designs of clinical trials

• Published in: Magnetic resonance imaging Vol. 29; no. 10; pp. 1382 - 1389
• Main Authors: Murphy, Kevin, Harris, Ashley D., Diukova, Ana, Evans, C. John, Lythgoe, David J., Zelaya, Fernando, Wise, Richard G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2011
• Subjects: Adult; Arterial Spin Labelling (ASL); Blood Flow Velocity - physiology; Cerebrovascular Circulation - physiology; Clinical trial; Clinical Trials as Topic - methods; Data Interpretation, Statistical; Female; FMRI; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Angiography - methods; Male; Pharmacological MRI; Power calculation; Radiology; Reproducibility of Results; Sample Size; Sensitivity and Specificity; Spin Labels; Pharmacological MRI; Clinical trial; Power calculation; Sample size; Arterial Spin Labelling (ASL); FMRI

Pulsed arterial spin labeling (PASL) is an increasingly common technique for noninvasively measuring cerebral blood flow (CBF) and has previously been shown to have good repeatability. It is likely to find a place in clinical trials and in particular the investigation of pharmaceutical agents active...