The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation - Aylon, Yael; Gershoni, Anat; Rotkopf, Ron; Biton, Inbal E.; Porat, Ziv; Koh, Anna P.; Sun, Xiaochen; Lee, Youngmin; Fiel, Maria-Isabel; Hoshida, Yujin; Friedman, Scott L.; Johnson, Randy L.; et al. (Genes & development, 2016)
Keywords: Animals; Cholesterol, Dietary - pharmacology; Fatty Liver - enzymology; Fatty Liver - genetics; Gene Deletion; Gene Expression Regulation - genetics; Hep G2 Cells; Homeostasis - genetics; Humans; Liver - drug effects; Liver - enzymology; Mice, Knockout; Protein Binding; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Research Paper; Signal Transduction; Sterol Regulatory Element Binding Protein 2 - genetics; Sterol Regulatory Element Binding Protein 2 - metabolism; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Lats; YAP; cholesterol; fatty liver; Hippo; p53