Inhibition of homodimerization of Toll-like receptor 4 by 4-oxo-4-(2-oxo-oxazolidin-3-yl)-but-2-enoic acid ethyl ester

• Published in: International immunopharmacology Vol. 11; no. 1; pp. 19 - 22
• Main Authors: Park, Se-Jeong, Kang, Seung Hee, Kang, Young Ku, Eom, Yong-Bin, Koh, Kwang Oh, Kim, Dae Young, Youn, Hyung-Sun
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 2011; Elsevier
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Biological and medical sciences; Blotting, Western; Dimerization; Fumarates - chemistry; Fumarates - pharmacology; Fumaryl oxazolidinone; HEK293 Cells; Humans; Immunoprecipitation; Interferon regulatory factor 3; Interferon Regulatory Factor-3 - immunology; Lipopolysaccharide; Lipopolysaccharides - pharmacology; Luciferases - genetics; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Medical sciences; Mice; Molecular Structure; NF-kappa B - genetics; NF-kappa B - immunology; Oxazolidinones - chemistry; Oxazolidinones - pharmacology; Pharmacology. Drug treatments; Plasmids; Protein Multimerization - drug effects; Signal Transduction; Toll-like receptor 4; Toll-Like Receptor 4 - antagonists & inhibitors; Toll-Like Receptor 4 - biosynthesis; Toll-Like Receptor 4 - chemistry; Transfection; Lipopolysaccharide; Fumaryl oxazolidinone; Interferon regulatory factor 3; Dimerization; Toll-like receptor 4; Ester; Antibiotic; Toll like receptor 4; Acids; Oxazolidinone derivative; Inhibitor; Antibacterial agent

Toll-like receptors (TLRs) recognize molecular structures derived from microbes and initiate innate immunity. The stimulation of TLR4 by lipopolysaccharide (LPS) triggers the activation of the myeloid differential factor 88 (MyD88)-dependent and toll-interleukin-1 receptor domain-containing adapter...