Human microglial state dynamics in Alzheimer’s disease progression

• Published in: Cell Vol. 186; no. 20; pp. 4386 - 4403.e29
• Main Authors: Sun, Na, Victor, Matheus B., Park, Yongjin P., Xiong, Xushen, Scannail, Aine Ni, Leary, Noelle, Prosper, Shaniah, Viswanathan, Soujanya, Luna, Xochitl, Boix, Carles A., James, Benjamin T., Tanigawa, Yosuke, Galani, Kyriaki, Mathys, Hansruedi, Jiang, Xueqiao, Ng, Ayesha P., Bennett, David A., Tsai, Li-Huei, Kellis, Manolis
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.09.2023
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's; cell states; disease progression; disease-stage response; Epigenome; Gene Expression Regulation; Humans; inflammation; Inflammation - pathology; iPSCs; microglia; Microglia - metabolism; neurodegenerative diseases; neuroglia; single-cell; transcription (genetics); transcription factors; Transcription Factors - metabolism; Transcriptome; transcriptomics; iPSCs; transcription factors; inflammation; single-cell; microglia; cell states; Alzheimer's; disease-stage response

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes and epigenomes across 443 human subjects and diverse Alzheimer’s disease (AD) pathological phenotypes. We annotate 12 micr...