The Importance of “Shrinkage” in Subgroup Analyses

• Published in: Annals of emergency medicine Vol. 55; no. 6; pp. 544 - 552.e3
• Main Authors: Lipsky, Ari M., Gausche-Hill, Marianne, Vienna, Muna, Lewis, Roger J.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.06.2010; Elsevier
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Bayes Theorem; Biological and medical sciences; Child; Clinical Trials as Topic - statistics & numerical data; Confidence Intervals; Data Interpretation, Statistical; Emergency; Humans; Intensive care medicine; Intubation, Intratracheal - statistics & numerical data; Laryngeal Masks - statistics & numerical data; Medical sciences; Models, Statistical; Odds Ratio; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Sample Size; Treatment Outcome; Victimology; Intensive care; Resuscitation

Subgroup analyses examine associations (eg, between treatment and outcome) within subsets of a larger study sample. The traditional approach evaluates the data in each of the subgroups independently. More accurate answers, however, may be expected when the rest of the data are considered in the anal...