A systematic review of definitions of extreme phenotypes of HIV control and progression

• Published in: AIDS (London) Vol. 28; no. 2; pp. 149 - 162
• Main Authors: GURDASANI, Deepti, ILES, Louise, PORTER, Kholoud, SANDHU, Manjinder S, DILLON, David G, YOUNG, Elizabeth H, OLSON, Ashley D, NARANBHAI, Vivek, FIDLER, Sarah, GKRANIA-KLOTSAS, Effrossyni, POST, Frank A, KELLAM, Paul
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 14.01.2014
• Subjects: Biological and medical sciences; Disease Progression; HIV Infections - diagnosis; HIV Infections - pathology; HIV Long-Term Survivors; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Phenotype; Terminology as Topic; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Prognosis; extreme-trait designs; Check; elite controllers; Prevention; slow progressors; HIV controllers; Evolution; definitions; Immunopathology; Retroviridae; Definition; long-term nonprogressors; AIDS; systematic review; Immune deficiency; Lentivirus; Long term; Infection; Virus; Phenotype; phenotypes; HIV; Viral disease; viremic controllers; Human immunodeficiency virus; Slow disease; Bibliographic review

The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlyin...