A systematic review of definitions of extreme phenotypes of HIV control and progression

The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlyin...

Full description

Saved in:
Bibliographic Details
Published inAIDS (London) Vol. 28; no. 2; pp. 149 - 162
Main Authors GURDASANI, Deepti, ILES, Louise, PORTER, Kholoud, SANDHU, Manjinder S, DILLON, David G, YOUNG, Elizabeth H, OLSON, Ashley D, NARANBHAI, Vivek, FIDLER, Sarah, GKRANIA-KLOTSAS, Effrossyni, POST, Frank A, KELLAM, Paul
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 14.01.2014
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlying these phenotypes. In this systematic review, we formally quantified the heterogeneity in definitions used for terms referring to extreme phenotypes in the literature, and identified common definitions and components used to describe these phenotypes. We assessed 714 definitions of HIV extreme phenotypes in 501 eligible studies published between 1 January 2000 and 15 March 2012, and identified substantial variation among these. This heterogeneity in definitions may represent important differences in biological endophenotypes and clinical progression profiles of individuals selected by these, suggesting the need for harmonized definitions. In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection.
AbstractList The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlying these phenotypes. In this systematic review, we formally quantified the heterogeneity in definitions used for terms referring to extreme phenotypes in the literature, and identified common definitions and components used to describe these phenotypes. We assessed 714 definitions of HIV extreme phenotypes in 501 eligible studies published between 1 January 2000 and 15 March 2012, and identified substantial variation among these. This heterogeneity in definitions may represent important differences in biological endophenotypes and clinical progression profiles of individuals selected by these, suggesting the need for harmonized definitions. In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection.
Author PORTER, Kholoud
DILLON, David G
GKRANIA-KLOTSAS, Effrossyni
SANDHU, Manjinder S
FIDLER, Sarah
ILES, Louise
YOUNG, Elizabeth H
KELLAM, Paul
GURDASANI, Deepti
POST, Frank A
OLSON, Ashley D
NARANBHAI, Vivek
AuthorAffiliation b Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Wort's Causeway, Cambridge
d Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
h King's College London, Weston Education Centre
e Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford
c Medical Research Council, Clinical Trials Unit, Aviation House, London, UK
g Cambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge
a Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton
i Division of Infection and Immunity, University College London, London, UK
f Imperial College Healthcare NHS Trust, London
AuthorAffiliation_xml – name: d Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
– name: g Cambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge
– name: h King's College London, Weston Education Centre
– name: f Imperial College Healthcare NHS Trust, London
– name: i Division of Infection and Immunity, University College London, London, UK
– name: b Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Wort's Causeway, Cambridge
– name: a Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton
– name: c Medical Research Council, Clinical Trials Unit, Aviation House, London, UK
– name: e Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford
Author_xml – sequence: 1
  givenname: Deepti
  surname: GURDASANI
  fullname: GURDASANI, Deepti
  organization: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
– sequence: 2
  givenname: Louise
  surname: ILES
  fullname: ILES, Louise
  organization: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
– sequence: 3
  givenname: Kholoud
  surname: PORTER
  fullname: PORTER, Kholoud
  organization: Medical Research Council, Clinical Trials Unit, Aviation House, London, United Kingdom
– sequence: 4
  givenname: Manjinder S
  surname: SANDHU
  fullname: SANDHU, Manjinder S
  organization: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
– sequence: 5
  givenname: David G
  surname: DILLON
  fullname: DILLON, David G
  organization: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
– sequence: 6
  givenname: Elizabeth H
  surname: YOUNG
  fullname: YOUNG, Elizabeth H
  organization: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
– sequence: 7
  givenname: Ashley D
  surname: OLSON
  fullname: OLSON, Ashley D
  organization: Medical Research Council, Clinical Trials Unit, Aviation House, London, United Kingdom
– sequence: 8
  givenname: Vivek
  surname: NARANBHAI
  fullname: NARANBHAI, Vivek
  organization: Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
– sequence: 9
  givenname: Sarah
  surname: FIDLER
  fullname: FIDLER, Sarah
  organization: Imperial College Healthcare NHS Trust, London, United Kingdom
– sequence: 10
  givenname: Effrossyni
  surname: GKRANIA-KLOTSAS
  fullname: GKRANIA-KLOTSAS, Effrossyni
  organization: Cambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge, United Kingdom
– sequence: 11
  givenname: Frank A
  surname: POST
  fullname: POST, Frank A
  organization: King's College London, Weston Education Centre, United Kingdom
– sequence: 12
  givenname: Paul
  surname: KELLAM
  fullname: KELLAM, Paul
  organization: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28403246$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/24149086$$D View this record in MEDLINE/PubMed
BookMark eNpdkV1L5DAUhoO46DjrPxDpjeBN3Xy1SW-Ewa8RhEVwdy9DmpxqpE1q0lHn39vR8WvPTTjJ877nkHcHbfrgAaE9go8IrsSv69npEf5WvNpAE8IFy4tCkE00wbSs8ooJvI12UrofkQJLuYW2KSe8wrKcoH-zLC3TAJ0enMkiPDp4ykKTWWicd4MLPq1aeB4idJD1d-DDsOzh9XZ--TczwQ8xtJn2NutjuI2Q0qj6iX40uk2wuz6n6M_52c3JPL_6fXF5MrvKDZfVkFtChWRgqOZGWCzrwhJha2CW6VIQY5qqxkTLUlcggGhsm7KgnJZEl7imDZui4zffflF3YA2M2-hW9dF1Oi5V0E59f_HuTt2GR8WkpAzz0eBwbRDDwwLSoDqXDLSt9hAWSa0-SmAimRxR_oaaGFKK0HyMIVitMlFjJur_TEbZ_tcVP0TvIYzAwRrQyei2idoblz45yTGjvGQvim-YAg
CitedBy_id crossref_primary_10_1097_QAD_0000000000003072
crossref_primary_10_3389_fimmu_2020_622343
crossref_primary_10_3390_math9172025
crossref_primary_10_1186_s12929_019_0577_y
crossref_primary_10_1093_infdis_jiz127
crossref_primary_10_1016_S2352_3018_14_70016_5
crossref_primary_10_1371_journal_pone_0137140
crossref_primary_10_1016_j_bbrc_2024_149830
crossref_primary_10_1128_mBio_02338_17
crossref_primary_10_3389_fimmu_2022_908697
crossref_primary_10_1002_jia2_25675
crossref_primary_10_5604_01_3001_0010_7044
crossref_primary_10_1016_S2352_3018_19_30264_4
crossref_primary_10_2174_1570162X16666180817115830
crossref_primary_10_2217_fvl_2018_0207
crossref_primary_10_1097_QAI_0000000000002485
crossref_primary_10_3389_fimmu_2022_879124
crossref_primary_10_1007_s11904_017_0364_x
crossref_primary_10_3389_fmicb_2021_661446
crossref_primary_10_1097_QAD_0000000000001050
crossref_primary_10_12688_f1000research_15029_1
crossref_primary_10_1371_journal_pone_0086719
crossref_primary_10_3389_fmicb_2020_00357
crossref_primary_10_3389_fmicb_2021_670016
crossref_primary_10_12688_f1000research_53683_1
crossref_primary_10_1007_s10461_024_04396_x
crossref_primary_10_1016_j_meegid_2017_01_007
crossref_primary_10_1093_ofid_ofad067
crossref_primary_10_1172_JCI146136
crossref_primary_10_1016_j_ijid_2023_11_030
crossref_primary_10_3389_fimmu_2022_926499
crossref_primary_10_1097_QAI_0000000000001825
crossref_primary_10_1371_journal_pcbi_1007401
crossref_primary_10_1128_JVI_01805_17
crossref_primary_10_3389_fviro_2022_917902
crossref_primary_10_3389_fimmu_2018_01576
crossref_primary_10_1097_COH_0000000000000488
crossref_primary_10_20948_prepr_2017_52
crossref_primary_10_1186_s12879_016_1647_3
crossref_primary_10_3390_biomedicines10092172
crossref_primary_10_1016_j_csbj_2021_04_056
crossref_primary_10_1038_ni_3147
crossref_primary_10_2217_epi_2021_0237
crossref_primary_10_3389_fimmu_2019_01062
crossref_primary_10_3390_jcm8030311
crossref_primary_10_1007_s13365_020_00876_7
crossref_primary_10_1016_S2352_3018_19_30089_X
crossref_primary_10_1177_2049936120958536
crossref_primary_10_1097_QAI_0000000000002108
crossref_primary_10_1002_jmv_29214
crossref_primary_10_1111_imr_13217
crossref_primary_10_1097_QAD_0000000000002009
crossref_primary_10_1097_QAD_0000000000002007
crossref_primary_10_1038_s41598_018_33481_0
crossref_primary_10_1038_s41577_020_0274_9
crossref_primary_10_1097_QAD_0000000000000860
crossref_primary_10_3389_fgene_2018_00720
crossref_primary_10_3390_jcm9082452
crossref_primary_10_1038_s41598_017_08716_1
crossref_primary_10_1097_QAI_0000000000002052
crossref_primary_10_1097_QAI_0000000000003066
crossref_primary_10_1128_MMBR_00155_20
crossref_primary_10_3389_fimmu_2018_00900
crossref_primary_10_1093_cid_ciu573
crossref_primary_10_1093_ofid_ofz182
crossref_primary_10_1007_s10958_021_05258_w
crossref_primary_10_3389_fimmu_2022_904342
crossref_primary_10_1371_journal_pone_0123674
crossref_primary_10_1097_QAD_0000000000000596
crossref_primary_10_3389_fimmu_2021_634832
crossref_primary_10_3389_fimmu_2020_00261
crossref_primary_10_1080_21505594_2020_1788887
crossref_primary_10_1371_journal_pone_0131922
Cites_doi 10.1086/433188
10.1517/14712590802571928
10.1086/655782
10.1086/596067
10.1186/1742-4690-6-4
10.1016/S0140-6736(05)62697-9
10.1097/QAI.0b013e31818ce709
10.1159/000049521
10.1111/j.1348-0421.2010.00259.x
10.1086/597278
10.1128/JVI.02652-10
10.1371/journal.pone.0029844
10.1126/science.1195271
10.1097/QAD.0b013e32832d0825
10.1371/journal.pmed.1000097
10.1016/j.immuni.2007.08.010
10.1097/00002030-200205030-00002
10.4049/jimmunol.162.11.6942
10.1097/QAD.0b013e32832b44c8
10.1016/j.biopha.2006.08.002
10.1371/journal.ppat.1000781
10.1128/JVI.05608-11
10.1371/journal.pone.0011079
10.1086/646609
ContentType Journal Article
Copyright 2015 INIST-CNRS
2014 Wolters Kluwer Health | Lippincott Williams & Wilkins 2014
Copyright_xml – notice: 2015 INIST-CNRS
– notice: 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins 2014
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1097/QAD.0000000000000049
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1473-5571
EndPage 162
ExternalDocumentID 10_1097_QAD_0000000000000049
24149086
28403246
Genre Review
Research Support, Non-U.S. Gov't
Systematic Review
Journal Article
GrantInformation_xml – fundername: Medical Research Council
  grantid: MC_UU_12023/15
– fundername: Wellcome Trust
– fundername: Medical Research Council
  grantid: G0901213
– fundername: Medical Research Council
  grantid: G0701652
GroupedDBID ---
.GJ
.XZ
.Z2
01R
08R
0R~
1CY
1J1
23M
2WC
354
40H
4Q1
4Q2
4Q3
53G
5GY
5RE
5VS
71W
77Y
7O~
85S
8L-
AAAXR
AAGIX
AAHPQ
AAJCS
AAMOA
AAMTA
AAPBV
AAQKA
AARTV
AASOK
AASXQ
AAXQO
ABASU
ABBUW
ABDIG
ABFLS
ABIVO
ABXVJ
ABZAD
ACCJW
ACDDN
ACEWG
ACGFS
ACOAL
ACWDW
ACWRI
ACXNZ
ADBBV
ADFPA
ADNKB
AE3
AE6
AEBDS
AENEX
AFDTB
AFFNX
AFUWQ
AGINI
AHRYX
AHVBC
AIJEX
AJIOK
AJNYG
AKULP
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
AWKKM
BAWUL
BOYCO
BQLVK
BS7
BYPQX
C45
CAG
COF
CS3
DIK
DIWNM
DUNZO
E.X
E3Z
EBS
EJD
EX3
F2K
F2L
F2M
F2N
F5P
FL-
FW0
GQDEL
H0~
HZ~
IKREB
IKYAY
IN~
IPNFZ
IQODW
JF9
JG8
JK3
JK8
K8S
KD2
KMI
KQ8
L-C
L7B
N4W
N9A
N~7
N~B
N~M
O9-
OAG
OAH
OBH
OCUKA
ODA
ODMTH
OHH
OHYEH
OJAPA
OK1
OL1
OLB
OLG
OLH
OLU
OLV
OLW
OLY
OLZ
OPUJH
OPX
ORVUJ
OUVQU
OVD
OVDNE
OVIDH
OVLEI
OVOZU
OWU
OWV
OWW
OWX
OWY
OWZ
OXXIT
P-K
P2P
R58
RIG
RLZ
S4R
S4S
SJN
T8P
TEORI
TR2
TSPGW
UAP
V2I
VVN
W3M
WOQ
WOW
X3V
X3W
XJT
XXN
XYM
YFH
ZGI
ZXP
ZZMQN
AAAAV
AAIQE
AAUEB
ABJNI
ACILI
ADGGA
ADHPY
AEETU
AFEXH
AHOMT
AHQNM
AINUH
AJNWD
AJZMW
AMNEI
CGR
CUY
CVF
ECM
EIF
FCALG
NPM
AAYXX
CITATION
7X8
5PM
ID FETCH-LOGICAL-c489t-d12783ec2a4c7d08b5d17dbe3d3a671ccf9b01a86a9e7e1a0df6524261a60b2f3
ISSN 0269-9370
IngestDate Tue Sep 17 21:21:47 EDT 2024
Fri Aug 16 20:52:48 EDT 2024
Fri Aug 23 03:00:08 EDT 2024
Sat Sep 28 08:29:11 EDT 2024
Fri Nov 25 01:03:31 EST 2022
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Prognosis
extreme-trait designs
Check
elite controllers
Prevention
slow progressors
HIV controllers
Evolution
definitions
Immunopathology
Retroviridae
Definition
long-term nonprogressors
AIDS
systematic review
Immune deficiency
Lentivirus
Long term
Infection
Virus
Phenotype
phenotypes
HIV
Viral disease
viremic controllers
Human immunodeficiency virus
Slow disease
Bibliographic review
Language English
License CC BY 4.0
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c489t-d12783ec2a4c7d08b5d17dbe3d3a671ccf9b01a86a9e7e1a0df6524261a60b2f3
Notes SourceType-Scholarly Journals-1
ObjectType-Feature-4
ObjectType-Undefined-1
content type line 23
ObjectType-Review-2
ObjectType-Article-3
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC3882304
PMID 24149086
PQID 1490701838
PQPubID 23479
PageCount 14
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3882304
proquest_miscellaneous_1490701838
crossref_primary_10_1097_QAD_0000000000000049
pubmed_primary_24149086
pascalfrancis_primary_28403246
PublicationCentury 2000
PublicationDate 2014-01-14
PublicationDateYYYYMMDD 2014-01-14
PublicationDate_xml – month: 01
  year: 2014
  text: 2014-01-14
  day: 14
PublicationDecade 2010
PublicationPlace Hagerstown, MD
PublicationPlace_xml – name: Hagerstown, MD
– name: England
PublicationTitle AIDS (London)
PublicationTitleAlternate AIDS
PublicationYear 2014
Publisher Lippincott Williams & Wilkins
Publisher_xml – name: Lippincott Williams & Wilkins
References Diop (R4-1-20210130) 2006; 60
Canducci (R3-1-20210130) 2009; 6
Baker (R18-1-20210130) 2009; 9
Moher (R20-1-20210130) 2009; 6
Fontaine (R13-1-20210130) 2009; 199
Casado (R14-1-20210130) 2010; 5
Limou (R19-1-20210130) 2010; 202
Okulicz (R1-1-20210130) 2009; 200
Grabar (R2-1-20210130) 2009; 23
Pereyra (R16-1-20210130) 2010; 330
Hendel (R24-1-20210130) 1999; 162
Limou (R5-1-20210130) 2009; 199
Zhang (R10-1-20210130) 2010; 54
Walker (R17-1-20210130) 2007; 15
Mandalia (R22-1-20210130) 2012; 7
Shaw (R12-1-20210130) 2011; 85
Deeks (R7-1-20210130) 2007; 27
Lajoie (R15-1-20210130) 2009; 23
Kamya (R8-1-20210130) 2011; 85
Rotger (R6-1-20210130) 2010; 6
Gillespie (R9-1-20210130) 2002; 16
Knapp (R21-1-20210130) 2001; 126
Rappaport (R25-1-20210130) 1997; 349
Madec (R23-1-20210130) 2009; 50
Lambotte (R11-1-20210130) 2005; 41
References_xml – volume: 41
  start-page: 1053
  year: 2005
  ident: R11-1-20210130
  article-title: HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication.
  publication-title: Clin Infect Dis
  doi: 10.1086/433188
  contributor:
    fullname: Lambotte
– volume: 9
  start-page: 55
  year: 2009
  ident: R18-1-20210130
  article-title: Elite control of HIV infection: implications for vaccine design.
  publication-title: Expert Opin Biol Ther
  doi: 10.1517/14712590802571928
  contributor:
    fullname: Baker
– volume: 202
  start-page: 908
  year: 2010
  ident: R19-1-20210130
  article-title: Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.
  publication-title: J Infect Dis
  doi: 10.1086/655782
  contributor:
    fullname: Limou
– volume: 199
  start-page: 419
  year: 2009
  ident: R5-1-20210130
  article-title: Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
  publication-title: J Infect Dis
  doi: 10.1086/596067
  contributor:
    fullname: Limou
– volume: 6
  start-page: 4
  year: 2009
  ident: R3-1-20210130
  article-title: Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV-1) gp120 CD4-binding site in a group of long term non progressor (LTNP) subjects.
  publication-title: Retrovirology
  doi: 10.1186/1742-4690-6-4
  contributor:
    fullname: Canducci
– volume: 349
  start-page: 922
  year: 1997
  ident: R25-1-20210130
  article-title: 32bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)62697-9
  contributor:
    fullname: Rappaport
– volume: 50
  start-page: 19
  year: 2009
  ident: R23-1-20210130
  article-title: Early control of HIV-1 infection in long-term nonprogressors followed since diagnosis in the ANRS SEROCOHEMOCO cohort.
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0b013e31818ce709
  contributor:
    fullname: Madec
– volume: 126
  start-page: 248
  year: 2001
  ident: R21-1-20210130
  article-title: Highly active antiretroviral therapy responders exhibit a phenotypic lymphocyte pattern comparable to that of long-term nonprogressors.
  publication-title: Int Arch Allergy Immunol
  doi: 10.1159/000049521
  contributor:
    fullname: Knapp
– volume: 54
  start-page: 625
  year: 2010
  ident: R10-1-20210130
  article-title: Alterations of CD4() CD25() Foxp3() regulatory T cells in HIV-infected slow progressors of former blood donors in China.
  publication-title: Microbiol Immunol
  doi: 10.1111/j.1348-0421.2010.00259.x
  contributor:
    fullname: Zhang
– volume: 199
  start-page: 1007
  year: 2009
  ident: R13-1-20210130
  article-title: HIV infection affects blood myeloid dendritic cells after successful therapy and despite nonprogressing clinical disease.
  publication-title: J Infect Dis
  doi: 10.1086/597278
  contributor:
    fullname: Fontaine
– volume: 85
  start-page: 5949
  year: 2011
  ident: R8-1-20210130
  article-title: Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1hy and HLA-B57.
  publication-title: J Virol
  doi: 10.1128/JVI.02652-10
  contributor:
    fullname: Kamya
– volume: 7
  start-page: e29844
  year: 2012
  ident: R22-1-20210130
  article-title: Are long-term nonprogressors very slow progressors Insights from the Chelsea and Westminster HIV cohort.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0029844
  contributor:
    fullname: Mandalia
– volume: 330
  start-page: 1551
  year: 2010
  ident: R16-1-20210130
  article-title: The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
  publication-title: Science
  doi: 10.1126/science.1195271
  contributor:
    fullname: Pereyra
– volume: 23
  start-page: 1437
  year: 2009
  ident: R15-1-20210130
  article-title: Persistence of high levels of blood soluble human leukocyte antigen-G is associated with rapid progression of HIV infection.
  publication-title: AIDS
  doi: 10.1097/QAD.0b013e32832d0825
  contributor:
    fullname: Lajoie
– volume: 15
  start-page: 134
  year: 2007
  ident: R17-1-20210130
  article-title: Elite control of HIV infection: implications for vaccines and treatment.
  publication-title: Top HIV Med
  contributor:
    fullname: Walker
– volume: 6
  start-page: e1000097
  year: 2009
  ident: R20-1-20210130
  article-title: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000097
  contributor:
    fullname: Moher
– volume: 27
  start-page: 406
  year: 2007
  ident: R7-1-20210130
  article-title: Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy.
  publication-title: Immunity
  doi: 10.1016/j.immuni.2007.08.010
  contributor:
    fullname: Deeks
– volume: 16
  start-page: 961
  year: 2002
  ident: R9-1-20210130
  article-title: Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B57.
  publication-title: AIDS
  doi: 10.1097/00002030-200205030-00002
  contributor:
    fullname: Gillespie
– volume: 162
  start-page: 6942
  year: 1999
  ident: R24-1-20210130
  article-title: New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS.
  publication-title: J Immunol
  doi: 10.4049/jimmunol.162.11.6942
  contributor:
    fullname: Hendel
– volume: 23
  start-page: 1163
  year: 2009
  ident: R2-1-20210130
  article-title: Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV.
  publication-title: AIDS
  doi: 10.1097/QAD.0b013e32832b44c8
  contributor:
    fullname: Grabar
– volume: 60
  start-page: 569
  year: 2006
  ident: R4-1-20210130
  article-title: Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort.
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2006.08.002
  contributor:
    fullname: Diop
– volume: 6
  start-page: e1000781
  year: 2010
  ident: R6-1-20210130
  article-title: Genome-wide mRNA expression correlates of viral control in CD4 T-cells from HIV-1-infected individuals.
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1000781
  contributor:
    fullname: Rotger
– volume: 85
  start-page: 11422
  year: 2011
  ident: R12-1-20210130
  article-title: Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.
  publication-title: J Virol
  doi: 10.1128/JVI.05608-11
  contributor:
    fullname: Shaw
– volume: 5
  start-page: e11079
  year: 2010
  ident: R14-1-20210130
  article-title: Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0011079
  contributor:
    fullname: Casado
– volume: 200
  start-page: 1714
  year: 2009
  ident: R1-1-20210130
  article-title: Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study.
  publication-title: J Infect Dis
  doi: 10.1086/646609
  contributor:
    fullname: Okulicz
SSID ssj0005088
Score 2.4635212
SecondaryResourceType review_article
Snippet The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to...
SourceID pubmedcentral
proquest
crossref
pubmed
pascalfrancis
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 149
SubjectTerms Biological and medical sciences
Disease Progression
HIV Infections - diagnosis
HIV Infections - pathology
HIV Long-Term Survivors
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Medical sciences
Phenotype
Terminology as Topic
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Title A systematic review of definitions of extreme phenotypes of HIV control and progression
URI https://www.ncbi.nlm.nih.gov/pubmed/24149086
https://search.proquest.com/docview/1490701838
https://pubmed.ncbi.nlm.nih.gov/PMC3882304
Volume 28
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagSAgJVTzLUqiMxA2l2Hk5OUYssAWKhGhFb5ETO20OJKvu7oVfz4ztvLaLBOwh2jiJI-X7Mhnb38wQ8trXkeSMFV4lmcSk2qkntdSeCHyhqzKMmdHmnH6NF-fhp4voYpDbmuiSdXFc_toZV_I_qEIb4IpRsv-AbN8pNMB_wBe2gDBs_wrj7EYiZhOEonRVN3UvcQPzi5OAb1DN1eKUq2ldwLiv06nbZAHtpdXENmOHNTuZfx-X_ejnDT5urpVc2YpQYLVQHNPTzNXR_tJu6mHtZ153S_xGRz8U9eoNTi8xcxETbjKCo4DFs0Ggx9oa0FAEXhTZsiqdhfWTEZP8kbnkNl3pDTNu0wN_y-Y2vWT_m54OYCx_GmjBDcEFzK2c2uYr3R26Te5grkQsrzA_-TyogICLXURlKt7uuiXmi3adTJyX-0u5gveosgVQdo1QtoW2I8_l7AHZd0MOmln-PCS3dPOI3D11oorH5EdGBxpRSyPaVnREI9x1NKIDjbAVaEQdjSjQiI5o9IScf3h_9m7huXobXhkm6dpTHMuu6NKXYSkUS4pIcaEKHahAxoKXZZUWjMsklqkWmkumqjhCF4_LmBV-FTwle03b6GeEKqbS0lc61lyFIdNFFESy0n4ifY1O8ox43YPMlzatSt7JIQCDfBuDGTmaPO3-IvCuGIwJ4hl51T3-HAwkrnrJRrebVY7ICQZfLrjpgYVjuNrhOiNiAlR_AiZfnx5p6iuThD1IzBL18z_2eUjuDW_IC7K3vt7ol-DArosjQ8HftXqZ6A
link.rule.ids 230,314,780,784,885,27924,27925
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+systematic+review+of+definitions+of+extreme+phenotypes+of+HIV+control+and+progression&rft.jtitle=AIDS+%28London%29&rft.au=Gurdasani%2C+Deepti&rft.au=Iles%2C+Louise&rft.au=Dillon%2C+David+G&rft.au=Young%2C+Elizabeth+H&rft.date=2014-01-14&rft.eissn=1473-5571&rft.volume=28&rft.issue=2&rft.spage=149&rft_id=info:doi/10.1097%2FQAD.0000000000000049&rft_id=info%3Apmid%2F24149086&rft.externalDocID=24149086
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0269-9370&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0269-9370&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0269-9370&client=summon