Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression

Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease inhibition. Here, we demonstrate that a proport...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of biological chemistry Vol. 290; no. 44; pp. 26533 - 26548
Main Authors Ferrer-Mayorga, Gemma, Alvarez-Díaz, Silvia, Valle, Noelia, De Las Rivas, Javier, Mendes, Marta, Barderas, Rodrigo, Canals, Francesc, Tapia, Olga, Casal, J. Ignacio, Lafarga, Miguel, Muñoz, Alberto
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 30.10.2015
American Society for Biochemistry and Molecular Biology
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease inhibition. Here, we demonstrate that a proportion of cystatin D locates within the cell nucleus at specific transcriptionally active chromatin sites. Consistently, transcriptomic analysis show that cystatin D alters gene expression, including that of genes encoding transcription factors such as RUNX1, RUNX2, and MEF2C in HCT116 cells. In concordance with transcriptomic data, quantitative proteomic analysis identified 292 proteins differentially expressed in cystatin D-expressing cells involved in cell adhesion, cytoskeleton, and RNA synthesis and processing. Furthermore, using cytokine arrays we found that cystatin D reduces the secretion of several protumor cytokines such as fibroblast growth factor-4, CX3CL1/fractalkine, neurotrophin 4 oncostatin-M, pulmonary and activation-regulated chemokine/CCL18, and transforming growth factor B3. These results support an unanticipated role of cystatin D in the cell nucleus, controlling the transcription of specific genes involved in crucial cellular functions, which may mediate its protective action in colon cancer. Background: Cystatin D is a cysteine protease inhibitor with tumor suppressor action. Results: A proportion of cystatin D protein localizes within the cell nucleus at specific active chromatin sites and regulates gene transcription. Conclusion: Cystatin D is a multifunctional protein with protease inhibitory and gene regulatory activities. Significance: Regulation of cystatin D in colon cancer cells has phenotypic consequences beyond the inhibition of lysosomal and secreted cysteine proteases.
AbstractList Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease inhibition. Here, we demonstrate that a proportion of cystatin D locates within the cell nucleus at specific transcriptionally active chromatin sites. Consistently, transcriptomic analysis show that cystatin D alters gene expression, including that of genes encoding transcription factors such as RUNX1, RUNX2, and MEF2C in HCT116 cells. In concordance with transcriptomic data, quantitative proteomic analysis identified 292 proteins differentially expressed in cystatin D-expressing cells involved in cell adhesion, cytoskeleton, and RNA synthesis and processing. Furthermore, using cytokine arrays we found that cystatin D reduces the secretion of several protumor cytokines such as fibroblast growth factor-4, CX3CL1/fractalkine, neurotrophin 4 oncostatin-M, pulmonary and activation-regulated chemokine/CCL18, and transforming growth factor B3. These results support an unanticipated role of cystatin D in the cell nucleus, controlling the transcription of specific genes involved in crucial cellular functions, which may mediate its protective action in colon cancer.
Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease inhibition. Here, we demonstrate that a proportion of cystatin D locates within the cell nucleus at specific transcriptionally active chromatin sites. Consistently, transcriptomic analysis show that cystatin D alters gene expression, including that of genes encoding transcription factors such as RUNX1, RUNX2, and MEF2C in HCT116 cells. In concordance with transcriptomic data, quantitative proteomic analysis identified 292 proteins differentially expressed in cystatin D-expressing cells involved in cell adhesion, cytoskeleton, and RNA synthesis and processing. Furthermore, using cytokine arrays we found that cystatin D reduces the secretion of several protumor cytokines such as fibroblast growth factor-4, CX3CL1/fractalkine, neurotrophin 4 oncostatin-M, pulmonary and activation-regulated chemokine/CCL18, and transforming growth factor B3. These results support an unanticipated role of cystatin D in the cell nucleus, controlling the transcription of specific genes involved in crucial cellular functions, which may mediate its protective action in colon cancer. Background: Cystatin D is a cysteine protease inhibitor with tumor suppressor action. Results: A proportion of cystatin D protein localizes within the cell nucleus at specific active chromatin sites and regulates gene transcription. Conclusion: Cystatin D is a multifunctional protein with protease inhibitory and gene regulatory activities. Significance: Regulation of cystatin D in colon cancer cells has phenotypic consequences beyond the inhibition of lysosomal and secreted cysteine proteases.
Background: Cystatin D is a cysteine protease inhibitor with tumor suppressor action. Results: A proportion of cystatin D protein localizes within the cell nucleus at specific active chromatin sites and regulates gene transcription. Conclusion: Cystatin D is a multifunctional protein with protease inhibitory and gene regulatory activities. Significance: Regulation of cystatin D in colon cancer cells has phenotypic consequences beyond the inhibition of lysosomal and secreted cysteine proteases. Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease inhibition. Here, we demonstrate that a proportion of cystatin D locates within the cell nucleus at specific transcriptionally active chromatin sites. Consistently, transcriptomic analysis show that cystatin D alters gene expression, including that of genes encoding transcription factors such as RUNX1 , RUNX2 , and MEF2C in HCT116 cells. In concordance with transcriptomic data, quantitative proteomic analysis identified 292 proteins differentially expressed in cystatin D-expressing cells involved in cell adhesion, cytoskeleton, and RNA synthesis and processing. Furthermore, using cytokine arrays we found that cystatin D reduces the secretion of several protumor cytokines such as fibroblast growth factor-4, CX3CL1/fractalkine, neurotrophin 4 oncostatin-M, pulmonary and activation-regulated chemokine/CCL18, and transforming growth factor B3. These results support an unanticipated role of cystatin D in the cell nucleus, controlling the transcription of specific genes involved in crucial cellular functions, which may mediate its protective action in colon cancer.
Author Ferrer-Mayorga, Gemma
Barderas, Rodrigo
Tapia, Olga
De Las Rivas, Javier
Valle, Noelia
Mendes, Marta
Lafarga, Miguel
Casal, J. Ignacio
Alvarez-Díaz, Silvia
Muñoz, Alberto
Canals, Francesc
Author_xml – sequence: 1
  givenname: Gemma
  surname: Ferrer-Mayorga
  fullname: Ferrer-Mayorga, Gemma
  organization: Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, E-28029 Madrid, Spain
– sequence: 2
  givenname: Silvia
  surname: Alvarez-Díaz
  fullname: Alvarez-Díaz, Silvia
  organization: Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, E-28029 Madrid, Spain
– sequence: 3
  givenname: Noelia
  surname: Valle
  fullname: Valle, Noelia
  organization: Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, E-28029 Madrid, Spain
– sequence: 4
  givenname: Javier
  surname: De Las Rivas
  fullname: De Las Rivas, Javier
  organization: the Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas-Universidad de Salamanca, E-37007 Salamanca, Spain
– sequence: 5
  givenname: Marta
  surname: Mendes
  fullname: Mendes, Marta
  organization: the Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, E-28040 Madrid, Spain
– sequence: 6
  givenname: Rodrigo
  surname: Barderas
  fullname: Barderas, Rodrigo
  organization: the Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, E-28040 Madrid, Spain
– sequence: 7
  givenname: Francesc
  surname: Canals
  fullname: Canals, Francesc
  organization: the Proteomics Laboratory, Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona, E-08035, Spain
– sequence: 8
  givenname: Olga
  surname: Tapia
  fullname: Tapia, Olga
  organization: Departamento de Anatomía y Biología Celular, Facultad de Medicina, Universidad de Cantabria-Instituto de Investigación Valdecilla, E-39011 Santander, Spain
– sequence: 9
  givenname: J. Ignacio
  surname: Casal
  fullname: Casal, J. Ignacio
  organization: the Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, E-28040 Madrid, Spain
– sequence: 10
  givenname: Miguel
  surname: Lafarga
  fullname: Lafarga, Miguel
  organization: Departamento de Anatomía y Biología Celular, Facultad de Medicina, Universidad de Cantabria-Instituto de Investigación Valdecilla, E-39011 Santander, Spain
– sequence: 11
  givenname: Alberto
  surname: Muñoz
  fullname: Muñoz, Alberto
  email: amunoz@iib.uam.es
  organization: Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, E-28029 Madrid, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26364852$$D View this record in MEDLINE/PubMed
BookMark eNp1kU1vEzEQhi1URNPCmRvykUtSf63Xe0Gq0lKQUkCiSNwsZ3aWutrYwfZG9N_jNKWCA75YHj_zjuXnhByFGJCQ15wtOGvV2d0aFtecNwutGW-bZ2TGmZFz2fDvR2TGmODzTjTmmJzkfMfqUh1_QY6FllqZRszIuLzPxRUf6AVdRXAFM62Hcov00wQjTpm6Qr_6fT0O9ByK3yG9SS5kSH5bfAzUhZ5ex34aH7qvMOBD6UuKBWvW5a9twpwr-ZI8H9yY8dXjfkq-vb-8WX6Yrz5ffVyer-agTFfm0ElhGDCBrQPOJQ4OeT8MmrfGaOG4NqBQ8kZJVK4zTA1ibRQYaIxUrZan5N0hdzutN9gDhpLcaLfJb1y6t9F5--9N8Lf2R9xZpZWWXNSAt48BKf6cMBe78RlwHF3AOGXLW2F020jRVfTsgEKKOSccnsZwZveObHVk947swVHtePP36574P1Iq0B0ArH-085hsBo8BsPcJodg--v-G_waLQaN3
CitedBy_id crossref_primary_10_1016_j_biopha_2024_117001
crossref_primary_10_3390_ph12020087
crossref_primary_10_1016_j_genrep_2021_101027
crossref_primary_10_1038_s41598_017_04722_5
crossref_primary_10_1155_2016_6213872
crossref_primary_10_3390_ijms20246172
crossref_primary_10_3389_fimmu_2021_726984
crossref_primary_10_3389_fimmu_2021_742822
crossref_primary_10_3389_fnmol_2015_00073
crossref_primary_10_1038_s41598_022_17944_z
crossref_primary_10_3390_ijms241914613
crossref_primary_10_1111_jcmm_14552
crossref_primary_10_1055_a_0992_9114
crossref_primary_10_2147_NSS_S458637
crossref_primary_10_1021_acs_jproteome_7b00567
crossref_primary_10_1016_j_jsbmb_2018_07_002
crossref_primary_10_1016_j_ijbiomac_2017_04_071
crossref_primary_10_1016_j_semcancer_2020_05_018
crossref_primary_10_1016_j_biochi_2019_05_002
crossref_primary_10_1016_j_bcp_2021_114735
crossref_primary_10_3390_cancers12092413
crossref_primary_10_1016_j_canlet_2019_07_020
Cites_doi 10.2478/v10042-10-0067-2
10.1007/s11605-012-1921-7
10.1016/S0092-8674(02)00650-5
10.1016/j.bbapap.2011.10.002
10.1353/hpu.0.0257
10.1002/ijc.27964
10.2174/138920209789503941
10.1016/j.cell.2008.09.055
10.1002/pmic.200900441
10.1158/1541-7786.MCR-11-0256
10.1016/S1097-2765(04)00209-6
10.1186/1471-2105-11-221
10.1074/jbc.M108460200
10.1189/jlb.0112035
10.1016/j.cell.2009.02.001
10.2741/3254
10.1177/1947601912458284
10.1074/jbc.M706991200
10.1038/nprot.2008.211
10.1074/jbc.M109.034793
10.1093/carcin/bgq245
10.1172/JCI42918
10.1371/journal.pone.0063695
10.1016/S0021-9258(18)54958-9
10.1038/nprot.2010.192
10.1038/bjc.2011.553
10.1073/pnas.091062498
10.1093/biostatistics/4.2.249
10.1038/emboj.2012.270
10.1371/journal.pone.0024289
10.1371/journal.pone.0054211
10.1128/MCB.00135-06
10.1091/mbc.e08-03-0291
10.1172/JCI37205
10.1007/BF00202491
10.1002/dvdy.21699
10.4161/cc.6.1.3669
10.1074/jbc.M206821200
10.1158/0008-5472.CAN-11-4090
10.1038/onc.2012.328
10.2741/3255
10.1002/jso.23056
ContentType Journal Article
Copyright 2015 © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
2015 by The American Society for Biochemistry and Molecular Biology, Inc.
2015 by The American Society for Biochemistry and Molecular Biology, Inc. 2015 The American Society for Biochemistry and Molecular Biology, Inc.
Copyright_xml – notice: 2015 © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
– notice: 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
– notice: 2015 by The American Society for Biochemistry and Molecular Biology, Inc. 2015 The American Society for Biochemistry and Molecular Biology, Inc.
DBID 6I.
AAFTH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1074/jbc.M115.660175
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE


Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
DocumentTitleAlternate Nuclear Action of Cystatin D
EISSN 1083-351X
EndPage 26548
ExternalDocumentID 10_1074_jbc_M115_660175
26364852
S0021925820495298
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-DZ
-ET
-~X
0SF
18M
29J
2WC
34G
39C
4.4
53G
5BI
5GY
5RE
5VS
6I.
79B
85S
AAEDW
AAFTH
AAFWJ
AARDX
AAXUO
ABDNZ
ABOCM
ABPPZ
ABRJW
ACGFO
ACNCT
ADBBV
ADIYS
ADNWM
AENEX
AEXQZ
AFOSN
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AOIJS
BAWUL
BTFSW
CJ0
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
FDB
FRP
GROUPED_DOAJ
GX1
HH5
HYE
IH2
KQ8
L7B
N9A
OK1
P0W
P2P
R.V
RHF
RHI
RNS
ROL
RPM
SJN
TBC
TN5
TR2
UHB
UKR
UPT
VQA
W8F
WH7
WOQ
XSW
YQT
YSK
YWH
YZZ
ZA5
~02
~KM
0R~
AALRI
ADVLN
AITUG
AKRWK
CGR
CUY
CVF
ECM
EIF
H13
NPM
.55
.GJ
186
3O-
41~
6TJ
AAYJJ
AAYOK
AAYXX
ABFSI
ABTAH
ACSFO
ACYGS
AFFNX
AI.
C1A
CITATION
E.L
FA8
J5H
MVM
NHB
OHT
P-O
QZG
UQL
VH1
WHG
X7M
XJT
Y6R
YYP
ZE2
ZGI
ZY4
7X8
5PM
ID FETCH-LOGICAL-c489t-c93280c02e7ac113efae1dff6178862a168c4e31543e4a9804f2b84c8c5834763
IEDL.DBID RPM
ISSN 0021-9258
IngestDate Tue Sep 17 21:22:50 EDT 2024
Fri Oct 25 01:10:55 EDT 2024
Thu Nov 21 20:57:34 EST 2024
Sat Sep 28 08:24:34 EDT 2024
Fri Feb 23 02:44:54 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 44
Keywords cysteine protease
cytokine
protease inhibitor
colon cancer
gene expression
Language English
License This is an open access article under the CC BY license.
2015 by The American Society for Biochemistry and Molecular Biology, Inc.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c489t-c93280c02e7ac113efae1dff6178862a168c4e31543e4a9804f2b84c8c5834763
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Present address: The Scripps Research Institute, 10550 North Torrey Pines Rd., IMM10/R209, La Jolla, CA 92037.
Present address: The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Present address: Facultad de Ciencias Biosanitarias, Universidad Francisco de Vitoria, E-28223 Pozuelo de Alarcón, Madrid, Spain.
Both authors contributed equally to this work.
Present address: Biochemistry and Molecular Biology I Dept., Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
OpenAccessLink https://dx.doi.org/10.1074/jbc.M115.660175
PMID 26364852
PQID 1728675329
PQPubID 23479
PageCount 16
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4646312
proquest_miscellaneous_1728675329
crossref_primary_10_1074_jbc_M115_660175
pubmed_primary_26364852
elsevier_sciencedirect_doi_10_1074_jbc_M115_660175
PublicationCentury 2000
PublicationDate 2015-10-30
PublicationDateYYYYMMDD 2015-10-30
PublicationDate_xml – month: 10
  year: 2015
  text: 2015-10-30
  day: 30
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 11200 Rockville Pike, Suite 302, Rockville, MD 20852-3110, U.S.A
PublicationTitle The Journal of biological chemistry
PublicationTitleAlternate J Biol Chem
PublicationYear 2015
Publisher Elsevier Inc
American Society for Biochemistry and Molecular Biology
Publisher_xml – name: Elsevier Inc
– name: American Society for Biochemistry and Molecular Biology
References Freije, Abrahamson, Olafsson, Velasco, Grubb, López-Otín (bib4) 1991; 266
Yuen, McCrudden, Huang, Tham, Zhang, Zeng, Zhang, Hong (bib39) 2013; 8
Peláez-García, Barderas, Torres, Hernández-Varas, Teixidó, Bonilla, de Herreros, Casal (bib33) 2013; 8
Chuang, Ito, Ito (bib36) 2013; 132
Risueño, Fontanillo, Dinger, De Las Rivas (bib17) 2010; 11
Corcione, Ferretti, Pistoia (bib30) 2012; 92
Balbín, Freije, Abrahamson, Velasco, Grubb, López-Otin (bib3) 1993; 90
Gocheva, Joyce (bib9) 2007; 6
Cox (bib8) 2009; 14
Geiger, Wisniewski, Cox, Zanivan, Kruger, Ishihama, Mann (bib21) 2011; 6
Alvarez-Díaz, Valle, García, Peña, Freije, Quesada, Astudillo, Bonilla, López-Otín, Muñoz (bib5) 2009; 119
Ceru, Konjar, Maher, Repnik, Krizaj, Bencina, Renko, Nepveu, Zerovnik, Turk, Kopitar-Jerala (bib14) 2010; 285
Slattery, Lundgreen, Herrick, Caan, Potter, Wolff (bib38) 2011; 32
Chimge, Frenkel (bib35) 2013; 32
Reiser, Adair, Reinheckel (bib1) 2010; 120
Agrawal, Ekonjo, Teterycz, Zyoeko, Grzebieniak, Milan, Marek, Siewiński (bib7) 2010; 48
Duncan, Muratore-Schroeder, Cook, Garcia, Shabanowitz, Hunt, Allis (bib12) 2008; 135
Carmo-Fonseca (bib26) 2002; 108
Barderas, Bartolomé, Fernandez-Aceñero, Torres, Casal (bib23) 2012; 72
Xu, Wang, Chen, Ma, Shao, Chen, Jin (bib29) 2012; 16
Benjamini (bib20) 1995; 57
Ochieng, Chaudhuri (bib6) 2010; 21
Maubach, Lim, Zhuo (bib16) 2008; 19
Bulynko, Hsing, Mason, Tremethick, Grigoryev (bib13) 2006; 26
Fontanillo, Nogales-Cadenas, Pascual-Montano, De las Rivas (bib25) 2011; 6
Huang da, Sherman, Lempicki (bib24) 2009; 4
Kosaka, Sakamoto, Terada, Ochiya (bib32) 2009; 238
Carlsson, Ranki, Sipilä, Karenko, Abdel-Rahman, Ovaska, Siggberg, Aapola, Ässämäki, Häyry, Niiranen, Helle, Knuutila, Hautaniemi, Peltomäki, Krohn (bib40) 2012; 106
Ong, McGowan, Pearce, Irving, Kan, Grigoryev, Turk, Silverman, Brix, Bottomley, Whisstock, Pike (bib28) 2007; 282
Irizarry, Hobbs, Collin, Beazer-Barclay, Antonellis, Scherf, Speed (bib18) 2003; 4
Bolin, Tawara, Sutherland, Redshaw, Aranda, Moselhy, Anderson, Jorcyk (bib34) 2012; 3
Freitas, Cunha (bib42) 2009; 10
Tusher, Tibshirani, Chu (bib19) 2001; 98
Luque-García, Martínez-Torrecuadrada, Epifano, Cañamero, Babel, Casal (bib22) 2010; 10
Kim, Rooper, Xie, Kajdacsy-Balla, Barbolina (bib31) 2012; 10
Scheitz, Lee, McDermitt, Tumbar (bib37) 2012; 31
Wu, He, Chen, Yuan, Zeng, Lian, Zou, Lan, Wu, Lan (bib41) 2012; 106
Goulet, Baruch, Moon, Poirier, Sansregret, Erickson, Bogyo, Nepveu (bib11) 2004; 14
Irving, Shushanov, Pike, Popova, Brömme, Coetzer, Bottomley, Boulynko, Grigoryev, Whisstock (bib15) 2002; 277
Traweger, Fuchs, Krizbai, Weiger, Bauer, Bauer (bib43) 2003; 278
Turk, Stoka, Vasiljeva, Renko, Sun, Turk, Turk (bib2) 2012; 1824
Rivenbark, Coleman (bib10) 2009; 14
Moore, Proudfoot (bib27) 2009; 136
Risueño (10.1074/jbc.M115.660175_bib17) 2010; 11
Geiger (10.1074/jbc.M115.660175_bib21) 2011; 6
Tusher (10.1074/jbc.M115.660175_bib19) 2001; 98
Chuang (10.1074/jbc.M115.660175_bib36) 2013; 132
Irizarry (10.1074/jbc.M115.660175_bib18) 2003; 4
Barderas (10.1074/jbc.M115.660175_bib23) 2012; 72
Bulynko (10.1074/jbc.M115.660175_bib13) 2006; 26
Irving (10.1074/jbc.M115.660175_bib15) 2002; 277
Maubach (10.1074/jbc.M115.660175_bib16) 2008; 19
Ceru (10.1074/jbc.M115.660175_bib14) 2010; 285
Reiser (10.1074/jbc.M115.660175_bib1) 2010; 120
Goulet (10.1074/jbc.M115.660175_bib11) 2004; 14
Freije (10.1074/jbc.M115.660175_bib4) 1991; 266
Bolin (10.1074/jbc.M115.660175_bib34) 2012; 3
Duncan (10.1074/jbc.M115.660175_bib12) 2008; 135
Scheitz (10.1074/jbc.M115.660175_bib37) 2012; 31
Turk (10.1074/jbc.M115.660175_bib2) 2012; 1824
Corcione (10.1074/jbc.M115.660175_bib30) 2012; 92
Ochieng (10.1074/jbc.M115.660175_bib6) 2010; 21
Freitas (10.1074/jbc.M115.660175_bib42) 2009; 10
Ong (10.1074/jbc.M115.660175_bib28) 2007; 282
Rivenbark (10.1074/jbc.M115.660175_bib10) 2009; 14
Slattery (10.1074/jbc.M115.660175_bib38) 2011; 32
Gocheva (10.1074/jbc.M115.660175_bib9) 2007; 6
Kosaka (10.1074/jbc.M115.660175_bib32) 2009; 238
Balbín (10.1074/jbc.M115.660175_bib3) 1993; 90
Fontanillo (10.1074/jbc.M115.660175_bib25) 2011; 6
Agrawal (10.1074/jbc.M115.660175_bib7) 2010; 48
Luque-García (10.1074/jbc.M115.660175_bib22) 2010; 10
Wu (10.1074/jbc.M115.660175_bib41) 2012; 106
Moore (10.1074/jbc.M115.660175_bib27) 2009; 136
Yuen (10.1074/jbc.M115.660175_bib39) 2013; 8
Cox (10.1074/jbc.M115.660175_bib8) 2009; 14
Carlsson (10.1074/jbc.M115.660175_bib40) 2012; 106
Xu (10.1074/jbc.M115.660175_bib29) 2012; 16
Traweger (10.1074/jbc.M115.660175_bib43) 2003; 278
Kim (10.1074/jbc.M115.660175_bib31) 2012; 10
Huang da (10.1074/jbc.M115.660175_bib24) 2009; 4
Benjamini (10.1074/jbc.M115.660175_bib20) 1995; 57
Peláez-García (10.1074/jbc.M115.660175_bib33) 2013; 8
Chimge (10.1074/jbc.M115.660175_bib35) 2013; 32
Alvarez-Díaz (10.1074/jbc.M115.660175_bib5) 2009; 119
Carmo-Fonseca (10.1074/jbc.M115.660175_bib26) 2002; 108
References_xml – volume: 90
  start-page: 668
  year: 1993
  end-page: 669
  ident: bib3
  article-title: A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level
  publication-title: Hum. Genet
  contributor:
    fullname: López-Otin
– volume: 14
  start-page: 463
  year: 2009
  end-page: 474
  ident: bib8
  article-title: Cystatins and cancer
  publication-title: Front. Biosci
  contributor:
    fullname: Cox
– volume: 282
  start-page: 36980
  year: 2007
  end-page: 36986
  ident: bib28
  article-title: DNA accelerates the inhibition of human cathepsin V by serpins
  publication-title: J. Biol. Chem
  contributor:
    fullname: Pike
– volume: 92
  start-page: 51
  year: 2012
  end-page: 58
  ident: bib30
  article-title: CX3CL1/fractalkine is a novel regulator of normal and malignant human B cell function
  publication-title: J. Leukoc. Biol
  contributor:
    fullname: Pistoia
– volume: 26
  start-page: 4172
  year: 2006
  end-page: 4184
  ident: bib13
  article-title: Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin
  publication-title: Mol. Cell. Biol
  contributor:
    fullname: Grigoryev
– volume: 135
  start-page: 284
  year: 2008
  end-page: 294
  ident: bib12
  article-title: Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation
  publication-title: Cell
  contributor:
    fullname: Allis
– volume: 136
  start-page: 688
  year: 2009
  end-page: 700
  ident: bib27
  article-title: Pre-mRNA processing reaches back to transcription and ahead to translation
  publication-title: Cell
  contributor:
    fullname: Proudfoot
– volume: 48
  start-page: 323
  year: 2010
  end-page: 327
  ident: bib7
  article-title: Cysteine peptidases and their inhibitors in breast and genital cancer
  publication-title: Folia Histochem. Cytobiol
  contributor:
    fullname: Siewiński
– volume: 14
  start-page: 207
  year: 2004
  end-page: 219
  ident: bib11
  article-title: A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor
  publication-title: Mol. Cell
  contributor:
    fullname: Nepveu
– volume: 57
  start-page: 289
  year: 1995
  end-page: 300
  ident: bib20
  article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing
  publication-title: J. R. Stat. Soc
  contributor:
    fullname: Benjamini
– volume: 11
  start-page: 221
  year: 2010
  ident: bib17
  article-title: GATExplorer: genomic and transcriptomic explorer; mapping expression probes to gene loci, transcripts, exons and ncRNAs
  publication-title: BMC Bioinformatics
  contributor:
    fullname: De Las Rivas
– volume: 106
  start-page: 130
  year: 2012
  end-page: 137
  ident: bib41
  article-title: High expression of CD73 as a poor prognostic biomarker in human colorectal cancer
  publication-title: J. Surg. Oncol
  contributor:
    fullname: Lan
– volume: 16
  start-page: 1493
  year: 2012
  end-page: 1498
  ident: bib29
  article-title: High expression of CX3CL1/CX3CR1 axis predicts a poor prognosis of pancreatic ductal adenocarcinoma
  publication-title: J. Gastrointest. Surg
  contributor:
    fullname: Jin
– volume: 19
  start-page: 4238
  year: 2008
  end-page: 4248
  ident: bib16
  article-title: Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells
  publication-title: Mol. Biol. Cell
  contributor:
    fullname: Zhuo
– volume: 6
  start-page: 147
  year: 2011
  end-page: 157
  ident: bib21
  article-title: Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics
  publication-title: Nat. Protocols
  contributor:
    fullname: Mann
– volume: 108
  start-page: 513
  year: 2002
  end-page: 521
  ident: bib26
  article-title: The contribution of nuclear compartmentalization to gene regulation
  publication-title: Cell
  contributor:
    fullname: Carmo-Fonseca
– volume: 266
  start-page: 20538
  year: 1991
  end-page: 20543
  ident: bib4
  article-title: Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor
  publication-title: J. Biol. Chem
  contributor:
    fullname: López-Otín
– volume: 98
  start-page: 5116
  year: 2001
  end-page: 5121
  ident: bib19
  article-title: Significance analysis of microarrays applied to the ionizing radiation response
  publication-title: Proc. Natl. Acad. Sci. U.S.A
  contributor:
    fullname: Chu
– volume: 6
  start-page: 60
  year: 2007
  end-page: 64
  ident: bib9
  article-title: Cysteine cathepsins and the cutting edge of cancer invasion
  publication-title: Cell Cycle
  contributor:
    fullname: Joyce
– volume: 120
  start-page: 3421
  year: 2010
  end-page: 3431
  ident: bib1
  article-title: Specialized roles for cysteine cathepsins in health and disease
  publication-title: J. Clin. Invest
  contributor:
    fullname: Reinheckel
– volume: 32
  start-page: 2121
  year: 2013
  end-page: 2130
  ident: bib35
  article-title: The RUNX family in breast cancer: relationships with estrogen signaling
  publication-title: Oncogene
  contributor:
    fullname: Frenkel
– volume: 132
  start-page: 1260
  year: 2013
  end-page: 1271
  ident: bib36
  article-title: RUNX family: Regulation and diversification of roles through interacting proteins
  publication-title: Int. J. Cancer
  contributor:
    fullname: Ito
– volume: 119
  start-page: 2343
  year: 2009
  end-page: 2358
  ident: bib5
  article-title: Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells
  publication-title: J. Clin. Invest
  contributor:
    fullname: Muñoz
– volume: 14
  start-page: 453
  year: 2009
  end-page: 462
  ident: bib10
  article-title: Epigenetic regulation of cystatins in cancer
  publication-title: Front. Biosci
  contributor:
    fullname: Coleman
– volume: 277
  start-page: 13192
  year: 2002
  end-page: 13201
  ident: bib15
  article-title: Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation
  publication-title: J. Biol. Chem
  contributor:
    fullname: Whisstock
– volume: 1824
  start-page: 68
  year: 2012
  end-page: 88
  ident: bib2
  article-title: Cysteine cathepsins: from structure, function and regulation to new frontiers
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Turk
– volume: 6
  year: 2011
  ident: bib25
  article-title: Functional analysis beyond enrichment: non-redundant reciprocal linkage of genes and biological terms
  publication-title: PloS One
  contributor:
    fullname: De las Rivas
– volume: 238
  start-page: 265
  year: 2009
  end-page: 276
  ident: bib32
  article-title: Pleiotropic function of FGF-4: its role in development and stem cells
  publication-title: Dev. Dyn
  contributor:
    fullname: Ochiya
– volume: 32
  start-page: 318
  year: 2011
  end-page: 326
  ident: bib38
  article-title: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1, and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway
  publication-title: Carcinogenesis
  contributor:
    fullname: Wolff
– volume: 278
  start-page: 2692
  year: 2003
  end-page: 2700
  ident: bib43
  article-title: The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B
  publication-title: J. Biol. Chem
  contributor:
    fullname: Bauer
– volume: 10
  start-page: 940
  year: 2010
  end-page: 952
  ident: bib22
  article-title: Differential protein expression on the cell surface of colorectal cancer cells associated to tumor metastasis
  publication-title: Proteomics
  contributor:
    fullname: Casal
– volume: 72
  start-page: 2780
  year: 2012
  end-page: 2790
  ident: bib23
  article-title: High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis
  publication-title: Cancer Res
  contributor:
    fullname: Casal
– volume: 31
  start-page: 4124
  year: 2012
  end-page: 4139
  ident: bib37
  article-title: Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer
  publication-title: EMBO J
  contributor:
    fullname: Tumbar
– volume: 8
  year: 2013
  ident: bib39
  article-title: TAZ expression as a prognostic indicator in colorectal cancer
  publication-title: PloS One
  contributor:
    fullname: Hong
– volume: 285
  start-page: 10078
  year: 2010
  end-page: 10086
  ident: bib14
  article-title: Stefin B interacts with histones and cathepsin L in the nucleus
  publication-title: J. Biol. Chem
  contributor:
    fullname: Kopitar-Jerala
– volume: 21
  start-page: 51
  year: 2010
  end-page: 70
  ident: bib6
  article-title: Cystatin superfamily
  publication-title: J. Health Care Poor Underserved
  contributor:
    fullname: Chaudhuri
– volume: 4
  start-page: 249
  year: 2003
  end-page: 264
  ident: bib18
  article-title: Exploration, normalization, and summaries of high density oligonucleotide array probe level data
  publication-title: Biostatistics
  contributor:
    fullname: Speed
– volume: 4
  start-page: 44
  year: 2009
  end-page: 57
  ident: bib24
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat. Protocols
  contributor:
    fullname: Lempicki
– volume: 10
  start-page: 11
  year: 2012
  end-page: 24
  ident: bib31
  article-title: Fractalkine receptor CX
  publication-title: Mol. Cancer Res
  contributor:
    fullname: Barbolina
– volume: 3
  start-page: 117
  year: 2012
  end-page: 130
  ident: bib34
  article-title: Oncostatin M promotes mammary tumor metastasis to bone and osteolytic bone degradation
  publication-title: Genes Cancer
  contributor:
    fullname: Jorcyk
– volume: 8
  year: 2013
  ident: bib33
  article-title: FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer
  publication-title: PloS One
  contributor:
    fullname: Casal
– volume: 106
  start-page: 517
  year: 2012
  end-page: 524
  ident: bib40
  article-title: Potential role of a navigator gene
  publication-title: Br. J. Cancer
  contributor:
    fullname: Krohn
– volume: 10
  start-page: 550
  year: 2009
  end-page: 557
  ident: bib42
  article-title: Mechanisms and signals for the nuclear import of proteins
  publication-title: Curr. Genomics
  contributor:
    fullname: Cunha
– volume: 48
  start-page: 323
  year: 2010
  ident: 10.1074/jbc.M115.660175_bib7
  article-title: Cysteine peptidases and their inhibitors in breast and genital cancer
  publication-title: Folia Histochem. Cytobiol
  doi: 10.2478/v10042-10-0067-2
  contributor:
    fullname: Agrawal
– volume: 16
  start-page: 1493
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib29
  article-title: High expression of CX3CL1/CX3CR1 axis predicts a poor prognosis of pancreatic ductal adenocarcinoma
  publication-title: J. Gastrointest. Surg
  doi: 10.1007/s11605-012-1921-7
  contributor:
    fullname: Xu
– volume: 108
  start-page: 513
  year: 2002
  ident: 10.1074/jbc.M115.660175_bib26
  article-title: The contribution of nuclear compartmentalization to gene regulation
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)00650-5
  contributor:
    fullname: Carmo-Fonseca
– volume: 1824
  start-page: 68
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib2
  article-title: Cysteine cathepsins: from structure, function and regulation to new frontiers
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbapap.2011.10.002
  contributor:
    fullname: Turk
– volume: 21
  start-page: 51
  year: 2010
  ident: 10.1074/jbc.M115.660175_bib6
  article-title: Cystatin superfamily
  publication-title: J. Health Care Poor Underserved
  doi: 10.1353/hpu.0.0257
  contributor:
    fullname: Ochieng
– volume: 132
  start-page: 1260
  year: 2013
  ident: 10.1074/jbc.M115.660175_bib36
  article-title: RUNX family: Regulation and diversification of roles through interacting proteins
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.27964
  contributor:
    fullname: Chuang
– volume: 10
  start-page: 550
  year: 2009
  ident: 10.1074/jbc.M115.660175_bib42
  article-title: Mechanisms and signals for the nuclear import of proteins
  publication-title: Curr. Genomics
  doi: 10.2174/138920209789503941
  contributor:
    fullname: Freitas
– volume: 135
  start-page: 284
  year: 2008
  ident: 10.1074/jbc.M115.660175_bib12
  article-title: Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation
  publication-title: Cell
  doi: 10.1016/j.cell.2008.09.055
  contributor:
    fullname: Duncan
– volume: 10
  start-page: 940
  year: 2010
  ident: 10.1074/jbc.M115.660175_bib22
  article-title: Differential protein expression on the cell surface of colorectal cancer cells associated to tumor metastasis
  publication-title: Proteomics
  doi: 10.1002/pmic.200900441
  contributor:
    fullname: Luque-García
– volume: 10
  start-page: 11
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib31
  article-title: Fractalkine receptor CX3CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells
  publication-title: Mol. Cancer Res
  doi: 10.1158/1541-7786.MCR-11-0256
  contributor:
    fullname: Kim
– volume: 14
  start-page: 207
  year: 2004
  ident: 10.1074/jbc.M115.660175_bib11
  article-title: A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(04)00209-6
  contributor:
    fullname: Goulet
– volume: 11
  start-page: 221
  year: 2010
  ident: 10.1074/jbc.M115.660175_bib17
  article-title: GATExplorer: genomic and transcriptomic explorer; mapping expression probes to gene loci, transcripts, exons and ncRNAs
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-11-221
  contributor:
    fullname: Risueño
– volume: 277
  start-page: 13192
  year: 2002
  ident: 10.1074/jbc.M115.660175_bib15
  article-title: Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation
  publication-title: J. Biol. Chem
  doi: 10.1074/jbc.M108460200
  contributor:
    fullname: Irving
– volume: 92
  start-page: 51
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib30
  article-title: CX3CL1/fractalkine is a novel regulator of normal and malignant human B cell function
  publication-title: J. Leukoc. Biol
  doi: 10.1189/jlb.0112035
  contributor:
    fullname: Corcione
– volume: 136
  start-page: 688
  year: 2009
  ident: 10.1074/jbc.M115.660175_bib27
  article-title: Pre-mRNA processing reaches back to transcription and ahead to translation
  publication-title: Cell
  doi: 10.1016/j.cell.2009.02.001
  contributor:
    fullname: Moore
– volume: 14
  start-page: 453
  year: 2009
  ident: 10.1074/jbc.M115.660175_bib10
  article-title: Epigenetic regulation of cystatins in cancer
  publication-title: Front. Biosci
  doi: 10.2741/3254
  contributor:
    fullname: Rivenbark
– volume: 3
  start-page: 117
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib34
  article-title: Oncostatin M promotes mammary tumor metastasis to bone and osteolytic bone degradation
  publication-title: Genes Cancer
  doi: 10.1177/1947601912458284
  contributor:
    fullname: Bolin
– volume: 282
  start-page: 36980
  year: 2007
  ident: 10.1074/jbc.M115.660175_bib28
  article-title: DNA accelerates the inhibition of human cathepsin V by serpins
  publication-title: J. Biol. Chem
  doi: 10.1074/jbc.M706991200
  contributor:
    fullname: Ong
– volume: 4
  start-page: 44
  year: 2009
  ident: 10.1074/jbc.M115.660175_bib24
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat. Protocols
  doi: 10.1038/nprot.2008.211
  contributor:
    fullname: Huang da
– volume: 285
  start-page: 10078
  year: 2010
  ident: 10.1074/jbc.M115.660175_bib14
  article-title: Stefin B interacts with histones and cathepsin L in the nucleus
  publication-title: J. Biol. Chem
  doi: 10.1074/jbc.M109.034793
  contributor:
    fullname: Ceru
– volume: 32
  start-page: 318
  year: 2011
  ident: 10.1074/jbc.M115.660175_bib38
  article-title: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1, and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgq245
  contributor:
    fullname: Slattery
– volume: 120
  start-page: 3421
  year: 2010
  ident: 10.1074/jbc.M115.660175_bib1
  article-title: Specialized roles for cysteine cathepsins in health and disease
  publication-title: J. Clin. Invest
  doi: 10.1172/JCI42918
  contributor:
    fullname: Reiser
– volume: 8
  year: 2013
  ident: 10.1074/jbc.M115.660175_bib33
  article-title: FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer
  publication-title: PloS One
  doi: 10.1371/journal.pone.0063695
  contributor:
    fullname: Peláez-García
– volume: 266
  start-page: 20538
  year: 1991
  ident: 10.1074/jbc.M115.660175_bib4
  article-title: Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor
  publication-title: J. Biol. Chem
  doi: 10.1016/S0021-9258(18)54958-9
  contributor:
    fullname: Freije
– volume: 6
  start-page: 147
  year: 2011
  ident: 10.1074/jbc.M115.660175_bib21
  article-title: Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics
  publication-title: Nat. Protocols
  doi: 10.1038/nprot.2010.192
  contributor:
    fullname: Geiger
– volume: 106
  start-page: 517
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib40
  article-title: Potential role of a navigator gene NAV3 in colorectal cancer
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2011.553
  contributor:
    fullname: Carlsson
– volume: 98
  start-page: 5116
  year: 2001
  ident: 10.1074/jbc.M115.660175_bib19
  article-title: Significance analysis of microarrays applied to the ionizing radiation response
  publication-title: Proc. Natl. Acad. Sci. U.S.A
  doi: 10.1073/pnas.091062498
  contributor:
    fullname: Tusher
– volume: 4
  start-page: 249
  year: 2003
  ident: 10.1074/jbc.M115.660175_bib18
  article-title: Exploration, normalization, and summaries of high density oligonucleotide array probe level data
  publication-title: Biostatistics
  doi: 10.1093/biostatistics/4.2.249
  contributor:
    fullname: Irizarry
– volume: 57
  start-page: 289
  year: 1995
  ident: 10.1074/jbc.M115.660175_bib20
  article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing
  publication-title: J. R. Stat. Soc
  contributor:
    fullname: Benjamini
– volume: 31
  start-page: 4124
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib37
  article-title: Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer
  publication-title: EMBO J
  doi: 10.1038/emboj.2012.270
  contributor:
    fullname: Scheitz
– volume: 6
  year: 2011
  ident: 10.1074/jbc.M115.660175_bib25
  article-title: Functional analysis beyond enrichment: non-redundant reciprocal linkage of genes and biological terms
  publication-title: PloS One
  doi: 10.1371/journal.pone.0024289
  contributor:
    fullname: Fontanillo
– volume: 8
  year: 2013
  ident: 10.1074/jbc.M115.660175_bib39
  article-title: TAZ expression as a prognostic indicator in colorectal cancer
  publication-title: PloS One
  doi: 10.1371/journal.pone.0054211
  contributor:
    fullname: Yuen
– volume: 26
  start-page: 4172
  year: 2006
  ident: 10.1074/jbc.M115.660175_bib13
  article-title: Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin
  publication-title: Mol. Cell. Biol
  doi: 10.1128/MCB.00135-06
  contributor:
    fullname: Bulynko
– volume: 19
  start-page: 4238
  year: 2008
  ident: 10.1074/jbc.M115.660175_bib16
  article-title: Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e08-03-0291
  contributor:
    fullname: Maubach
– volume: 119
  start-page: 2343
  year: 2009
  ident: 10.1074/jbc.M115.660175_bib5
  article-title: Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells
  publication-title: J. Clin. Invest
  doi: 10.1172/JCI37205
  contributor:
    fullname: Alvarez-Díaz
– volume: 90
  start-page: 668
  year: 1993
  ident: 10.1074/jbc.M115.660175_bib3
  article-title: A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level
  publication-title: Hum. Genet
  doi: 10.1007/BF00202491
  contributor:
    fullname: Balbín
– volume: 238
  start-page: 265
  year: 2009
  ident: 10.1074/jbc.M115.660175_bib32
  article-title: Pleiotropic function of FGF-4: its role in development and stem cells
  publication-title: Dev. Dyn
  doi: 10.1002/dvdy.21699
  contributor:
    fullname: Kosaka
– volume: 6
  start-page: 60
  year: 2007
  ident: 10.1074/jbc.M115.660175_bib9
  article-title: Cysteine cathepsins and the cutting edge of cancer invasion
  publication-title: Cell Cycle
  doi: 10.4161/cc.6.1.3669
  contributor:
    fullname: Gocheva
– volume: 278
  start-page: 2692
  year: 2003
  ident: 10.1074/jbc.M115.660175_bib43
  article-title: The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B
  publication-title: J. Biol. Chem
  doi: 10.1074/jbc.M206821200
  contributor:
    fullname: Traweger
– volume: 72
  start-page: 2780
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib23
  article-title: High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-11-4090
  contributor:
    fullname: Barderas
– volume: 32
  start-page: 2121
  year: 2013
  ident: 10.1074/jbc.M115.660175_bib35
  article-title: The RUNX family in breast cancer: relationships with estrogen signaling
  publication-title: Oncogene
  doi: 10.1038/onc.2012.328
  contributor:
    fullname: Chimge
– volume: 14
  start-page: 463
  year: 2009
  ident: 10.1074/jbc.M115.660175_bib8
  article-title: Cystatins and cancer
  publication-title: Front. Biosci
  doi: 10.2741/3255
  contributor:
    fullname: Cox
– volume: 106
  start-page: 130
  year: 2012
  ident: 10.1074/jbc.M115.660175_bib41
  article-title: High expression of CD73 as a poor prognostic biomarker in human colorectal cancer
  publication-title: J. Surg. Oncol
  doi: 10.1002/jso.23056
  contributor:
    fullname: Wu
SSID ssj0000491
Score 2.3453376
Snippet Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and...
Background: Cystatin D is a cysteine protease inhibitor with tumor suppressor action. Results: A proportion of cystatin D protein localizes within the cell...
SourceID pubmedcentral
proquest
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 26533
SubjectTerms Cell Biology
Cell Line, Tumor
colon cancer
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Core Binding Factor Alpha 1 Subunit - genetics
Core Binding Factor Alpha 1 Subunit - metabolism
Core Binding Factor Alpha 2 Subunit - genetics
Core Binding Factor Alpha 2 Subunit - metabolism
Cystatins - genetics
Cystatins - metabolism
cysteine protease
cytokine
Cytokines - biosynthesis
Cytokines - genetics
gene expression
Gene Expression Regulation, Neoplastic
Humans
MEF2 Transcription Factors - genetics
MEF2 Transcription Factors - metabolism
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
protease inhibitor
Proteomics
Transcription, Genetic
Title Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression
URI https://dx.doi.org/10.1074/jbc.M115.660175
https://www.ncbi.nlm.nih.gov/pubmed/26364852
https://search.proquest.com/docview/1728675329
https://pubmed.ncbi.nlm.nih.gov/PMC4646312
Volume 290
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT9swFH6iXLbLtMF-dGzIk6Zpl7SJ7TjusepACFbEtCFxsxzHFp2og9ZWgv9-z06MxhAXjnHsyPKz3vte_Pl7AJ8xIhtdBeVW4XTGjSgyncsmm-CLRteubExk-Z6Ko3N-fFFebEGZ7sJE0r6pFyN_tRz5xWXkVl4vzTjxxMZn8xkXXLCCjgcwwPCbUvTkfnlfJi9wD2gpk55Pxce_azOaIwQaCUxDqlC0hgomuCzpY1HpIer8nzz5TzQ6fAkvehhJpt10X8GW9TuwO_WYQi9vyRcSiZ3xj_kOPJulom67cDW7DVeIFp58I9_bwIZaEXxAFEhOg7LxZkX0mvxchPbWkWn0hiQGtOReiPYNmbdNqPuFvYJudWw6C4oP-K2Dm55b61_D-eHBr9lR1hdcyAyXk3VmEMzJ3OTUVtoUBbNO26JxLlwjxMxHF0IabhmiLma5nsicO1pLbqQpJePoqd7Atm-9fQeEYs8g7u50SXlDc80Kh-FS5kI2CEr1EL6mBVfXna6GiufhFVdoJhXMpDozDYEmg6geFnThXqHXf3zQp2Q6hUscTkG0t-1mpUJBLsySGJ0M4W1nyrsZpO0whOqeke86BDHu-29wj0ZR7n5Pvn_yyD14jmAsysKy_ANsr_9s7EcEPOt6HwYnP-R-3OZ_AQY6_7s
link.rule.ids 230,314,727,780,784,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFH4a4zAuE2z8KD-GkRDikjaxHcc5VmVTgbaaxCbtZjmOIzqtzkRbif33PDvxxJh24RjHjiw_673vxZ-_B_ARI7LRhVduFY1OuBFZolNZJyW-qHXV5LUJLN-FmJ7zbxf5xQ7k8S5MIO2bajl0V6uhW_4M3MrrlRlFntjodD7hgguW0dEjeJyzosxikh4dMO8L5Xn2Ac1lVPQp-OiyMsM5gqChwESk8GVrqGCCy5w-FJfu485_6ZN_xaOTp7DfA0ky7ib8DHasO4DDscMkenVDPpFA7Qz_zA9gbxLLuh3C1eTGXyJaOvKFzFrPh1oTfEAcSBZe23i7JnpDfix9e9uQcfCHJIS06GCIdjWZt7Wv_IW9vHJ1aDr1mg_4rePfPbvWPYfzk-OzyTTpSy4khstykxiEczI1KbWFNlnGbKNtVjeNv0iIuY_OhDTcMsRdzHJdypQ3tJLcSJNLxtFXvYBd1zr7CgjFnl7evdE55TVNNcsaDJgyFbJGWKoH8DkuuLrulDVUOBEvuEIzKW8m1ZlpADQaRPXAoAv4Cv3-w4M-RNMpXGJ_DqKdbbdr5UtyYZ7EaDmAl50pb2cQt8MAijtGvu3g5bjvvsFdGmS5-135-r9Hvoe96dl8pmZfF9_fwBOEZkEklqVvYXfza2vfIfzZVEdhs_8BmJ4CKg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSLAXBBuXcjUSQrykSWzHcR-rbtWAtaoEk_ZmOb6IotWp1lZi_55jJ5420F54jGNHVs7ROd9JPn8HoY-QkbWqg3IrdypjmpeZKoTJRnDDqMZVRkeW75yfnLGv59X5jVZfkbSvm-XQX6yGfvkzcivXK50nnli-mE0YZ5yWJF8bl99HDyoKTpYK9RSEWd8sLzAQSCWSqk_N8l-NHs4ACA05FCN1aF1DOOVMVOSu3PQv9vybQnkjJ02foMc9mMTjbtNP0T3rD9Dh2EMhvbrCn3Ckd8bv5gfo0SS1djtEF5OrcJBo6fERPm0DJ2qD4QKwIJ4HfePdBqst_r4M463D4xgTcUxrKchg5Q2etSZ0_4JZQb06Di2C7gM86_h3z7D1z9DZ9PjH5CTr2y5kmonRNtMA6UShC2JrpcuSWqdsaZwLhwmh_lElF5pZCtiLWqZGomCONIJpoStBGcSr52jPt96-RJjAzCDx7lRFmCGFoqWDpCkKLgxAUzVAn9MLl-tOXUPGv-I1k2AmGcwkOzMNEEkGkT046JK-hNh_96IPyXQSXnH4F6K8bXcbGdpyQa1EyWiAXnSmvN5BcocBqm8Z-XpCkOS-fQc8NUpz95756r9XvkcPF0dTefpl_u012gd0FnViafEG7W0vd_YtIKBt8y76-h9VkgM9
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cystatin+D+Locates+in+the+Nucleus+at+Sites+of+Active+Transcription+and+Modulates+Gene+and+Protein+Expression&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Ferrer-Mayorga%2C+Gemma&rft.au=Alvarez-D%C3%ADaz%2C+Silvia&rft.au=Valle%2C+Noelia&rft.au=De+Las+Rivas%2C+Javier&rft.date=2015-10-30&rft.pub=Elsevier+Inc&rft.issn=0021-9258&rft.eissn=1083-351X&rft.volume=290&rft.issue=44&rft.spage=26533&rft.epage=26548&rft_id=info:doi/10.1074%2Fjbc.M115.660175&rft.externalDocID=S0021925820495298
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon