The Phagocytosis of Lacticaseibacillus casei and Its Immunomodulatory Properties on Human Monocyte-Derived Dendritic Cells Depend on the Expression of Lc-p75, a Bacterial Peptidoglycan Hydrolase

The human gut symbiont Lacticaseibacillus (L.) casei (previously Lactobacillus casei) is under intense research due to its wide range of immunomodulatory effects on the human host. Dendritic cells (DCs) are crucial players in the direct and indirect communication with lactobacilli in the gastrointes...

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Published inInternational journal of molecular sciences Vol. 23; no. 14; p. 7620
Main Authors Tóth, Márta, Muzsai, Szabolcs, Regulski, Krzysztof, Szendi-Szatmári, Tímea, Czimmerer, Zsolt, Rajnavölgyi, Éva, Chapot-Chartier, Marie-Pierre, Bácsi, Attila
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.07.2022
MDPI
Subjects
Antigen presentation
Bacteria
Cell division
Cell walls
Chemokines
Cytokines
Cytology
Dendritic cells
Enzymes
Gastrointestinal system
Gastrointestinal tract
Helper cells
Hydrolase
Immunomodulation
Inflammation
Internalization
Lactobacilli
lactobacillus
Life Sciences
Lymphocytes
Lymphocytes T
Monocytes
Morphology
Mutation
Pathogens
Peptidoglycan hydrolase
Phagocytosis
Probiotics
lactobacillus
phagocytosis
immunomodulation
dendritic cells
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Abstract The human gut symbiont Lacticaseibacillus (L.) casei (previously Lactobacillus casei) is under intense research due to its wide range of immunomodulatory effects on the human host. Dendritic cells (DCs) are crucial players in the direct and indirect communication with lactobacilli in the gastrointestinal tract. Here, we demonstrate that human monocyte-derived DCs (moDCs) are able to engulf L. casei BL23, in which the intact bacterial cell wall and morphology have a key role. The absence of the bacterial cell-wall-degrading enzyme, Lc-p75, in L. casei cells causes remarkable morphological changes, which have important consequences in the phagocytosis of L. casei by moDCs. Our results showed that the Lc-p75 mutation induced defective internalization and impaired proinflammatory and T-cell-polarizing cytokine secretion by bacteria-exposed moDCs. The T helper (Th) 1 and Th17 cell activating capacity of moDCs induced by the mutant L. casei was consequently reduced. Moreover, inhibition of the phagocytosis of wild-type bacteria showed similar results. Taken together, these data suggested that formation of short bacterial chains helps to exert the potent immunomodulatory properties of L. casei BL23.
AbstractList The human gut symbiont Lacticaseibacillus (L.) casei (previously Lactobacillus casei) is under intense research due to its wide range of immunomodulatory effects on the human host. Dendritic cells (DCs) are crucial players in the direct and indirect communication with lactobacilli in the gastrointestinal tract. Here, we demonstrate that human monocyte-derived DCs (moDCs) are able to engulf L. casei BL23, in which the intact bacterial cell wall and morphology have a key role. The absence of the bacterial cell-wall-degrading enzyme, Lc-p75, in L. casei cells causes remarkable morphological changes, which have important consequences in the phagocytosis of L. casei by moDCs. Our results showed that the Lc-p75 mutation induced defective internalization and impaired proinflammatory and T-cell-polarizing cytokine secretion by bacteria-exposed moDCs. The T helper (Th) 1 and Th17 cell activating capacity of moDCs induced by the mutant L. casei was consequently reduced. Moreover, inhibition of the phagocytosis of wild-type bacteria showed similar results. Taken together, these data suggested that formation of short bacterial chains helps to exert the potent immunomodulatory properties of L. casei BL23.
The human gut symbiont Lacticaseibacillus (L.) casei (previously Lactobacillus casei ) is under intense research due to its wide range of immunomodulatory effects on the human host. Dendritic cells (DCs) are crucial players in the direct and indirect communication with lactobacilli in the gastrointestinal tract. Here, we demonstrate that human monocyte-derived DCs (moDCs) are able to engulf L. casei BL23, in which the intact bacterial cell wall and morphology have a key role. The absence of the bacterial cell-wall-degrading enzyme, Lc-p75, in L. casei cells causes remarkable morphological changes, which have important consequences in the phagocytosis of L. casei by moDCs. Our results showed that the Lc-p75 mutation induced defective internalization and impaired proinflammatory and T-cell-polarizing cytokine secretion by bacteria-exposed moDCs. The T helper (Th) 1 and Th17 cell activating capacity of moDCs induced by the mutant L. casei was consequently reduced. Moreover, inhibition of the phagocytosis of wild-type bacteria showed similar results. Taken together, these data suggested that formation of short bacterial chains helps to exert the potent immunomodulatory properties of L. casei BL23.
Author Czimmerer, Zsolt
Regulski, Krzysztof
Bácsi, Attila
Rajnavölgyi, Éva
Muzsai, Szabolcs
Tóth, Márta
Szendi-Szatmári, Tímea
Chapot-Chartier, Marie-Pierre
AuthorAffiliation 7 Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; czimmerer.zsolt@med.unideb.hu
4 Gyula Petrányi Doctoral School of Clinical Immunology and Allergology, University of Debrecen, 4032 Debrecen, Hungary
6 Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; szatmari.timea@med.unideb.hu
1 Department of Immunology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; toth.marta@med.unideb.hu (M.T.); muzsai.szabolcs@med.unideb.hu (S.M.); rajnavolgyi.eva@gmail.com (É.R.)
2 Doctoral School of Molecular Cell and Immune Biology, University of Debrecen, 4032 Debrecen, Hungary
3 ELKH-DE Allergology Research Group, 4032 Debrecen, Hungary
5 INRAE, AgroParisTech, Micalis Institute, Université Paris-Saclay, 78350 Jouy-en-Josas, France; krzysztof.regulski@cellectis.com (K.R.); marie-pierre.chapot-chartier@inrae.fr (M.-P.C.-C.)
AuthorAffiliation_xml – name: 3 ELKH-DE Allergology Research Group, 4032 Debrecen, Hungary
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– name: 1 Department of Immunology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; toth.marta@med.unideb.hu (M.T.); muzsai.szabolcs@med.unideb.hu (S.M.); rajnavolgyi.eva@gmail.com (É.R.)
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CitedBy_id crossref_primary_10_1016_j_ijbiomac_2024_133195
crossref_primary_10_3390_biomedicines11061521
Cites_doi 10.3389/fmicb.2017.00321
10.1111/sji.12250
10.1371/journal.pone.0032301
10.1016/j.carres.2016.10.002
10.1113/jphysiol.2009.176370
10.1074/jbc.274.25.17406
10.1097/MOG.0b013e32834baa4d
10.1128/IAI.72.6.3299-3309.2004
10.1007/s00253-020-10487-1
10.1371/journal.pone.0045185
10.1038/s41598-020-75930-9
10.1038/nature18849
10.1038/nri.2017.136
10.1182/blood-2006-04-016840
10.1099/ijs.0.02325-0
10.1186/1475-2859-6-22
10.3389/fmicb.2019.00331
10.1039/C9FO02933H
10.3389/fimmu.2017.00427
10.1186/s13099-017-0162-4
10.1038/86373
10.3389/fimmu.2013.00445
10.1038/nrmicro2297
10.1038/nri3244
10.1016/j.tim.2003.12.011
10.1093/femsre/fuaa044
10.1189/jlb.0805484
10.1016/j.coi.2013.11.003
10.1038/nri2335
10.1038/sj.embor.7400248
10.1007/s00430-020-00691-1
10.1371/journal.pone.0120261
10.1038/nri.2015.18
10.3748/wjg.14.5570
10.4049/jimmunol.1300575
10.1186/s12886-017-0437-z
10.1128/IAI.01199-06
10.1111/j.1462-5822.2006.00694.x
10.1038/nrgastro.2014.66
10.4049/jimmunol.0902230
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Keywords lactobacillus
phagocytosis
immunomodulation
dendritic cells
Language English
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References Vermassen (ref_12) 2019; 10
(ref_40) 2003; 53
Pahtma (ref_29) 2015; 81
Rescigno (ref_25) 2001; 2
Wolf (ref_16) 2018; 18
ref_35
Yan (ref_13) 2011; 19
Bastos (ref_33) 2021; 45
Campana (ref_4) 2017; 9
Bene (ref_19) 2017; 8
Niedergang (ref_10) 2004; 12
Coombes (ref_24) 2008; 8
Ren (ref_2) 2020; 11
Sperandio (ref_3) 2016; 535
ref_15
Moretti (ref_11) 2014; 26
Latvala (ref_27) 2008; 14
Drakes (ref_17) 2004; 72
Hill (ref_1) 2014; 11
Underhill (ref_36) 2012; 12
LeBlanc (ref_5) 2020; 104
Yan (ref_7) 2011; 27
Seshadri (ref_22) 2013; 191
(ref_14) 2020; 10
Kramer (ref_39) 2006; 79
Bene (ref_18) 2017; 8
Alhede (ref_37) 2020; 209
Rochat (ref_9) 2007; 6
Dupage (ref_30) 2016; 16
ref_20
Lebeer (ref_34) 2010; 8
Gogolak (ref_21) 2007; 109
Gao (ref_23) 2017; 17
Niess (ref_26) 2006; 8
Ghosh (ref_28) 2010; 185
Travassos (ref_32) 2004; 5
Vieira (ref_8) 2013; 4
Resta (ref_6) 2009; 587
Kapetanovic (ref_38) 2007; 75
Schwandner (ref_31) 1999; 274
Vinogradov (ref_41) 2016; 435
References_xml – volume: 8
  start-page: 321
  year: 2017
  ident: ref_19
  article-title: Lactobacillus reuteri surface mucus adhesins upregulate inflammatory responses through interactions with innate C-Type lectin receptors
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.00321
  contributor:
    fullname: Bene
– volume: 81
  start-page: 23
  year: 2015
  ident: ref_29
  article-title: RGS16 restricts the pro-inflammatory response of monocytes
  publication-title: Scand. J. Immunol.
  doi: 10.1111/sji.12250
  contributor:
    fullname: Pahtma
– ident: ref_15
  doi: 10.1371/journal.pone.0032301
– volume: 435
  start-page: 156
  year: 2016
  ident: ref_41
  article-title: Structural studies of the rhamnose-rich cell wall polysaccharide of Lactobacillus casei BL23
  publication-title: Carbohydr. Res.
  doi: 10.1016/j.carres.2016.10.002
  contributor:
    fullname: Vinogradov
– volume: 587
  start-page: 4169
  year: 2009
  ident: ref_6
  article-title: Effects of probiotics and commensals on intestinal epithelial physiology: Implications for nutrient handling
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2009.176370
  contributor:
    fullname: Resta
– volume: 274
  start-page: 17406
  year: 1999
  ident: ref_31
  article-title: Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.25.17406
  contributor:
    fullname: Schwandner
– volume: 27
  start-page: 496
  year: 2011
  ident: ref_7
  article-title: Probiotics and immune health
  publication-title: Curr. Opin. Gastroenterol.
  doi: 10.1097/MOG.0b013e32834baa4d
  contributor:
    fullname: Yan
– volume: 72
  start-page: 3299
  year: 2004
  ident: ref_17
  article-title: Bacterial probiotic modulation of dendritic cells
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.72.6.3299-3309.2004
  contributor:
    fullname: Drakes
– volume: 104
  start-page: 3331
  year: 2020
  ident: ref_5
  article-title: Application of vitamin-producing lactic acid bacteria to treat intestinal inflammatory diseases
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-020-10487-1
  contributor:
    fullname: LeBlanc
– ident: ref_20
  doi: 10.1371/journal.pone.0045185
– volume: 10
  start-page: 19237
  year: 2020
  ident: ref_14
  article-title: Lactobacillus casei extracellular vesicles stimulate EGFR pathway likely due to the presence of proteins P40 and P75 bound to their surface
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-75930-9
– volume: 535
  start-page: 85
  year: 2016
  ident: ref_3
  article-title: Interactions between the microbiota and pathogenic bacteria in the gut
  publication-title: Nature
  doi: 10.1038/nature18849
  contributor:
    fullname: Sperandio
– volume: 18
  start-page: 243
  year: 2018
  ident: ref_16
  article-title: Peptidoglycan recognition by the innate immune system
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.136
  contributor:
    fullname: Wolf
– volume: 109
  start-page: 643
  year: 2007
  ident: ref_21
  article-title: Differentiation of CD1a− and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPARγ
  publication-title: Blood
  doi: 10.1182/blood-2006-04-016840
  contributor:
    fullname: Gogolak
– volume: 53
  start-page: 67
  year: 2003
  ident: ref_40
  article-title: Significant differences between Lactobacillus casei subsp. casei ATCC 393 T and a commonly used plasmid-cured derivative revealed by a polyphasic study
  publication-title: Int. J. Syst. Evol. Microbiol.
  doi: 10.1099/ijs.0.02325-0
– volume: 6
  start-page: 22
  year: 2007
  ident: ref_9
  article-title: Anti-inflammatory effects of Lactobacillus casei BL23 producing or not a manganese-dependant catalase on DSS-induced colitis in mice
  publication-title: Microb. Cell Fact.
  doi: 10.1186/1475-2859-6-22
  contributor:
    fullname: Rochat
– volume: 10
  start-page: 331
  year: 2019
  ident: ref_12
  article-title: Cell wall hydrolases in bacteria: Insight on the diversity of cell wall amidases, glycosidases and peptidases toward peptidoglycan
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.00331
  contributor:
    fullname: Vermassen
– volume: 11
  start-page: 1230
  year: 2020
  ident: ref_2
  article-title: Protective effects of lactic acid bacteria on gut epithelial barrier dysfunction are Toll like receptor 2 and protein kinase C dependent
  publication-title: Food Funct.
  doi: 10.1039/C9FO02933H
  contributor:
    fullname: Ren
– volume: 8
  start-page: 427
  year: 2017
  ident: ref_18
  article-title: Gut microbiota species can provoke both inflammatory and tolerogenic immune responses in human dendritic cells mediated by retinoic acid receptor alpha ligation
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00427
  contributor:
    fullname: Bene
– volume: 9
  start-page: 12
  year: 2017
  ident: ref_4
  article-title: Strain-specific probiotic properties of lactic acid bacteria and their interference with human intestinal pathogens invasion
  publication-title: Gut Pathog.
  doi: 10.1186/s13099-017-0162-4
  contributor:
    fullname: Campana
– volume: 2
  start-page: 361
  year: 2001
  ident: ref_25
  article-title: Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
  publication-title: Nat. Immunol.
  doi: 10.1038/86373
  contributor:
    fullname: Rescigno
– volume: 4
  start-page: 445
  year: 2013
  ident: ref_8
  article-title: The role of probiotics and prebiotics in inducing gut immunity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2013.00445
  contributor:
    fullname: Vieira
– volume: 8
  start-page: 171
  year: 2010
  ident: ref_34
  article-title: Host interactions of probiotic bacterial surface molecules: Comparison with commensals and pathogens
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2297
  contributor:
    fullname: Lebeer
– volume: 12
  start-page: 492
  year: 2012
  ident: ref_36
  article-title: Information processing during phagocytosis
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3244
  contributor:
    fullname: Underhill
– volume: 12
  start-page: 79
  year: 2004
  ident: ref_10
  article-title: Dendritic cells: The host Achille’s heel for mucosal pathogens?
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2003.12.011
  contributor:
    fullname: Niedergang
– volume: 45
  start-page: fuaa044
  year: 2021
  ident: ref_33
  article-title: Uptake, recognition and responses to peptidoglycan in the mammalian host
  publication-title: FEMS Microbiol. Rev.
  doi: 10.1093/femsre/fuaa044
  contributor:
    fullname: Bastos
– volume: 79
  start-page: 860
  year: 2006
  ident: ref_39
  article-title: Impaired dendritic cell function in Crohn’s disease patients with NOD2 3020insC mutation
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0805484
  contributor:
    fullname: Kramer
– volume: 26
  start-page: 100
  year: 2014
  ident: ref_11
  article-title: Insights into phagocytosis-coupled activation of pattern recognition receptors and inflammasomes
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2013.11.003
  contributor:
    fullname: Moretti
– volume: 8
  start-page: 435
  year: 2008
  ident: ref_24
  article-title: Dendritic cells in intestinal immune regulation
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2335
  contributor:
    fullname: Coombes
– volume: 5
  start-page: 1000
  year: 2004
  ident: ref_32
  article-title: Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
  publication-title: EMBO Rep.
  doi: 10.1038/sj.embor.7400248
  contributor:
    fullname: Travassos
– volume: 209
  start-page: 669
  year: 2020
  ident: ref_37
  article-title: Bacterial aggregate size determines phagocytosis efficiency of polymorphonuclear leukocytes
  publication-title: Med. Microbiol. Immunol.
  doi: 10.1007/s00430-020-00691-1
  contributor:
    fullname: Alhede
– ident: ref_35
  doi: 10.1371/journal.pone.0120261
– volume: 16
  start-page: 149
  year: 2016
  ident: ref_30
  article-title: Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2015.18
  contributor:
    fullname: Dupage
– volume: 14
  start-page: 5570
  year: 2008
  ident: ref_27
  article-title: Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.14.5570
  contributor:
    fullname: Latvala
– volume: 19
  start-page: 231
  year: 2011
  ident: ref_13
  article-title: Functional analysis of the p40 and p75 proteins from lactobacillus casei BL23
  publication-title: J. Mol. Microbiol. Biotechnol.
  contributor:
    fullname: Yan
– volume: 191
  start-page: 1586
  year: 2013
  ident: ref_22
  article-title: Human CD1a Deficiency Is Common and Genetically Regulated
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1300575
  contributor:
    fullname: Seshadri
– volume: 17
  start-page: 4
  year: 2017
  ident: ref_23
  article-title: The influence of actin depolymerization induced by Cytochalasin D and mechanical stretch on interleukin-8 expression and JNK phosphorylation levels in human retinal pigment epithelial cells
  publication-title: BMC Ophthalmol.
  doi: 10.1186/s12886-017-0437-z
  contributor:
    fullname: Gao
– volume: 75
  start-page: 830
  year: 2007
  ident: ref_38
  article-title: Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.01199-06
  contributor:
    fullname: Kapetanovic
– volume: 8
  start-page: 558
  year: 2006
  ident: ref_26
  article-title: Dendritic cells in the recognition of intestinal microbiota
  publication-title: Cell. Microbiol.
  doi: 10.1111/j.1462-5822.2006.00694.x
  contributor:
    fullname: Niess
– volume: 11
  start-page: 506
  year: 2014
  ident: ref_1
  article-title: Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2014.66
  contributor:
    fullname: Hill
– volume: 185
  start-page: 3685
  year: 2010
  ident: ref_28
  article-title: Gene-Specific Repression of Proinflammatory Cytokines in Stimulated Human Macrophages by Nuclear IκBα
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0902230
  contributor:
    fullname: Ghosh
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Snippet The human gut symbiont Lacticaseibacillus (L.) casei (previously Lactobacillus casei) is under intense research due to its wide range of immunomodulatory...
The human gut symbiont Lacticaseibacillus (L.) casei (previously Lactobacillus casei ) is under intense research due to its wide range of immunomodulatory...
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SubjectTerms Antigen presentation
Bacteria
Cell division
Cell walls
Chemokines
Cytokines
Cytology
Dendritic cells
Enzymes
Gastrointestinal system
Gastrointestinal tract
Helper cells
Hydrolase
Immunomodulation
Inflammation
Internalization
Lactobacilli
lactobacillus
Life Sciences
Lymphocytes
Lymphocytes T
Monocytes
Morphology
Mutation
Pathogens
Peptidoglycan hydrolase
Phagocytosis
Probiotics
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Title The Phagocytosis of Lacticaseibacillus casei and Its Immunomodulatory Properties on Human Monocyte-Derived Dendritic Cells Depend on the Expression of Lc-p75, a Bacterial Peptidoglycan Hydrolase
URI https://www.proquest.com/docview/2694020114/abstract/
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https://pubmed.ncbi.nlm.nih.gov/PMC9319067
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