A steroid hormone agonist reduces female fitness in insecticide-resistant Anopheles populations

• Published in: Insect biochemistry and molecular biology Vol. 121; p. 103372
• Main Authors: Brown, Faye, Paton, Douglas G., Catteruccia, Flaminia, Ranson, Hilary, Ingham, Victoria A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2020
• Subjects: 20-Hydroxyecdysone; adults; Animals; Anopheles; Anopheles - drug effects; Anopheles - genetics; Anopheles gambiae; bed nets; cross resistance; cytochrome P-450; ecdysterone; Ecdysterone - agonists; egg production; Female; females; Genetic Fitness - drug effects; hematophagy; Hydrazines - pharmacology; insect biochemistry; Insecticide resistance; Insecticide Resistance - genetics; insecticides; Insecticides - pharmacology; Juvenile Hormones - pharmacology; longevity; Malaria; Methoxyfenozide; molecular biology; morbidity; mortality; Mosquito Vectors - drug effects; Mosquito Vectors - genetics; Plasmodium; pyrethrins; steroid hormones; Vector control; Anopheles; 20-Hydroxyecdysone; Insecticide resistance; Malaria; Methoxyfenozide; Vector control

Insecticide based vector control tools such as insecticide treated bednets and indoor residual spraying represent the cornerstones of malaria control programs. Resistance to chemistries used in these programs is now widespread and represents a significant threat to the gains seen in reducing malaria...