Single tumor-initiating cells evade immune clearance by recruiting type II macrophages

• Published in: Genes & development Vol. 31; no. 3; pp. 247 - 259
• Main Authors: Guo, Xiaocan, Zhao, Yang, Yan, Huan, Yang, Yingcheng, Shen, Shuying, Dai, Xiaoming, Ji, Xinyan, Ji, Fubo, Gong, Xing-Guo, Li, Li, Bai, Xueli, Feng, Xin-Hua, Liang, Tingbo, Ji, Junfang, Chen, Lei, Wang, Hongyang, Zhao, Bin
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.02.2017
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Communication - immunology; Cell Cycle Proteins; Cell Transformation, Neoplastic - immunology; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cells, Cultured; Hepatocyte Growth Factor - physiology; Hepatocytes - immunology; Hepatocytes - metabolism; Hepatocytes - pathology; Homeodomain Proteins - physiology; Humans; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Macrophages - cytology; Macrophages - immunology; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Neoplastic Stem Cells - cytology; Neoplastic Stem Cells - immunology; Phosphoproteins - genetics; Phosphoproteins - metabolism; Protein-Serine-Threonine Kinases - physiology; Proto-Oncogene Proteins - physiology; Research Paper; Tumor Suppressor Protein p53 - physiology; YAP; macrophage; liver cancer; tumor-initiating cell; Hippo pathway; immunosurveillance

Tumor infiltrated type II (M2) macrophages promote tumorigenesis by suppressing immune clearance, promoting proliferation, and stimulating angiogenesis. Interestingly, macrophages were also found to enrich in small foci of altered hepatocytes containing liver tumor-initiating cells (TICs). However,...