L233P mutation in the bovine leukemia virus Tax protein has impact on annexin A3 and type I collagen secretion by host cells

• Published in: Veterinary microbiology Vol. 256; p. 109042
• Main Authors: Tomiyasu, Takafumi, Sato, Ayuki, Mori, Hiroshi, Okazaki, Katsunori
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2021; Elsevier BV
• Subjects: Amino acids; angiogenesis; Annexin A3; Bovine leukemia virus; Bovine leukemia virus (BLV); Bovine leukosis; Cell culture; Cell proliferation; chemoattractants; Chemotactic factors; Collagen; Collagen (type I); complement; culture media; Endothelial cells; enzootic bovine leukosis; Epithelium; etiological agents; Extracellular matrix; Homeostasis; immune evasion; Leukemia; Leukemogenesis; Leukosis; Matrix protein; Metastases; metastasis; microbiology; mutation; neoplasm cells; Pigment epithelium-derived factor; Proteins; proteomics; secretion; Tax; Tax protein; Tumors; Type I collagen; Vascularization; Leukemogenesis; Tax; Annexin A3; Bovine leukemia virus (BLV); Type I collagen

•Bovine leukemia virus Tax modulated host cell secretion of potential tumor makers.•L233-Tax stimulated annexin A3 secretion.•L233-Tax suppressed type I collagen secretion.•Both L233- and P233-Tax suppressed potentially antiangiogenic molecules secretion. Bovine leukemia virus (BLV) is the causative...