A novel regulatory element between the human FGA and FGG genes

• Published in: Thrombosis and haemostasis Vol. 108; no. 3; p. 427
• Main Authors: Fish, Richard J, Neerman-Arbez, Marguerite
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2012
• Subjects: Animals; Animals, Genetically Modified; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor - metabolism; Chromatin Immunoprecipitation; Chromosome Mapping; Conserved Sequence; Enhancer Elements, Genetic - genetics; Fibrinogen - genetics; Gene Expression Regulation; Genes, Reporter; Genes, Synthetic; Green Fluorescent Proteins - biosynthesis; Green Fluorescent Proteins - genetics; HEK293 Cells - metabolism; Hep G2 Cells - metabolism; Hepatocytes - metabolism; Humans; Larva; Liver Neoplasms - pathology; Luciferases - biosynthesis; Luciferases - genetics; Mice; Recombinant Fusion Proteins - biosynthesis; Recombinant Fusion Proteins - genetics; Transgenes; Zebrafish - growth & development

High circulating fibrinogen levels correlate with cardiovascular disease (CVD) risk. Fibrinogen levels vary between people and also change in response to physiological and environmental stimuli. A modest proportion of the variation in fibrinogen levels can be explained by genotype, inferring that va...