Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis

• Published in: Cancer letters Vol. 474; pp. 138 - 150
• Main Authors: Kuo, Cheng-Liang, Chou, Han-Yu, Chiu, Yi-Chieh, Cheng, An Ning, Fan, Chi-Chen, Chang, Yu-Ning, Chen, Chung-Hsing, Jiang, Shih Sheng, Chen, Nien-Jung, Lee, Alan Yueh-Luen
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2020; Elsevier Limited
• Subjects: Angiogenesis; Animals; Apoptosis; ATP-Dependent Proteases - genetics; ATP-Dependent Proteases - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cancer immunotherapy; Carboxylate reductase; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell activation; Cell Proliferation; Cytokines; delta-1-Pyrroline-5-Carboxylate Reductase; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Immunoescape; Immunoglobulins; Immunosuppressive agents; Immunotherapy; Inflammation; Interleukin 13; Interleukin 6; Laboratory animals; Lung Neoplasms - immunology; Lung Neoplasms - metabolism; Lung Neoplasms - secondary; Lymphocytes T; Macrophage Activation - immunology; Macrophages; Male; Melanoma - immunology; Melanoma - metabolism; Melanoma - pathology; Mesenchyme; Metabolism; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Lon; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Mouth Neoplasms - immunology; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; NF-κB protein; Oxidative Stress; Polarization; Prognosis; Proteins; PYCR1; Pyrroline Carboxylate Reductases - genetics; Pyrroline Carboxylate Reductases - metabolism; Pyrroline-5-carboxylate reductase; Reactive oxygen species; Reactive Oxygen Species - metabolism; ROS; Tumor Cells, Cultured; Tumor Microenvironment; Vascular endothelial growth factor; Xenograft Model Antitumor Assays; New York; Israel; United States > US; Taiwan; PYCR1; Immunoescape; Tumor microenvironment; Mitochondrial Lon; ROS

Mitochondrial Lon is a chaperone protein whose upregulation increases the production of mitochondrial reactive oxygen species (ROS). However, there is a lack of information in detail on how mitochondrial Lon regulates cancer metastasis through ROS production in the tumor microenvironment (TME). Our...