Aspirin and clopidogrel treatment impair nitric oxide biosynthesis by platelets

• Published in: Journal of molecular and cellular cardiology Vol. 45; no. 2; pp. 223 - 229
• Main Authors: O’Kane, Peter D., Reebye, Vikash, Ji, Yong, Stratton, Paula, Jackson, Graham, Ferro, Albert
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2008
• Subjects: Adrenergic beta-Antagonists - adverse effects; Adrenergic beta-Antagonists - therapeutic use; Adult; Aspirin; Aspirin - therapeutic use; Beta adrenoceptors; Blood Platelets - drug effects; Blood Platelets - enzymology; Blood Platelets - metabolism; Cardiovascular; Clopidogrel; Coronary Disease - drug therapy; Coronary Disease - metabolism; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitric oxide; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; Nitric Oxide - physiology; Platelet Aggregation Inhibitors - therapeutic use; Platelets; Receptors, Adrenergic, beta - physiology; Signal Transduction - drug effects; Signal Transduction - physiology; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Clopidogrel; Aspirin; Platelets; Beta adrenoceptors; Nitric oxide

Aspirin and clopidogrel are used therapeutically for their anti-platelet effects. We examined the effects of aspirin and clopidogrel on basal and β-adrenoceptor (β-AR)-mediated platelet nitric oxide (NO) synthesis in healthy subjects and patients with coronary heart disease (CHD). Healthy subjects (...