Cancer stem cells in glioblastoma

• Published in: Genes & development Vol. 29; no. 12; pp. 1203 - 1217
• Main Authors: Lathia, Justin D., Mack, Stephen C., Mulkearns-Hubert, Erin E., Valentim, Claudia L.L., Rich, Jeremy N.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 15.06.2015
• Subjects: Animals; Brain Neoplasms - genetics; Brain Neoplasms - immunology; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Gene Expression Regulation, Neoplastic; Glioblastoma - genetics; Glioblastoma - immunology; Glioblastoma - pathology; Glioblastoma - therapy; Humans; Neoplastic Stem Cells - cytology; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Review; brain tumor; glioma; tumor-initiating cell; glioblastoma; cancer stem cell; stem cell

Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing,...