Cancer stem cells in glioblastoma
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing,...
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| Published in | Genes & development Vol. 29; no. 12; pp. 1203 - 1217 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Cold Spring Harbor Laboratory Press
15.06.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units; rather, they function within an ecological system, both actively remodeling the microenvironment and receiving critical maintenance cues from their niches. To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial. |
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| AbstractList | Glioblastoma is the most prevalent and malignant primary brain tumor, containing self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. In this review, Lathia et al. discuss how the integration of genetics, epigenetics, and metabolism has shaped our understanding of how CSCs function to drive GBM growth.
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units; rather, they function within an ecological system, both actively remodeling the microenvironment and receiving critical maintenance cues from their niches. To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial. Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units; rather, they function within an ecological system, both actively remodeling the microenvironment and receiving critical maintenance cues from their niches. To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial. |
| Author | Mack, Stephen C. Lathia, Justin D. Valentim, Claudia L.L. Mulkearns-Hubert, Erin E. Rich, Jeremy N. |
| AuthorAffiliation | 3 Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA 2 Department of Molecular Medicine, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA 1 Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA |
| AuthorAffiliation_xml | – name: 1 Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA – name: 2 Department of Molecular Medicine, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA – name: 3 Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA |
| Author_xml | – sequence: 1 givenname: Justin D. orcidid: 0000-0003-3168-7290 surname: Lathia fullname: Lathia, Justin D. – sequence: 2 givenname: Stephen C. orcidid: 0000-0001-9620-4742 surname: Mack fullname: Mack, Stephen C. – sequence: 3 givenname: Erin E. orcidid: 0000-0002-5214-8504 surname: Mulkearns-Hubert fullname: Mulkearns-Hubert, Erin E. – sequence: 4 givenname: Claudia L.L. surname: Valentim fullname: Valentim, Claudia L.L. – sequence: 5 givenname: Jeremy N. orcidid: 0000-0001-7845-5302 surname: Rich fullname: Rich, Jeremy N. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26109046$$D View this record in MEDLINE/PubMed |
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| Snippet | Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate... Glioblastoma is the most prevalent and malignant primary brain tumor, containing self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor... |
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| SubjectTerms | Animals Brain Neoplasms - genetics Brain Neoplasms - immunology Brain Neoplasms - pathology Brain Neoplasms - therapy Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - immunology Glioblastoma - pathology Glioblastoma - therapy Humans Neoplastic Stem Cells - cytology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Review |
| Title | Cancer stem cells in glioblastoma |
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