Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 29; pp. E5900 - E5909
• Main Authors: Chew, Valerie, Lai, Liyun, Pan, Lu, Lim, Chun Jye, Li, Juntao, Ong, Raymond, Chua, Camillus, Leong, Jing Yao, Lim, Kiat Hon, Toh, Han Chong, Lee, Ser Yee, Chan, Chung Yip, Goh, Brian K. P., Chung, Alexander, Chow, Pierce K. H., Albani, Salvatore
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 18.07.2017
• Series: PNAS Plus
• Subjects: Antigen (tumor-associated); Antigens; Biological Sciences; CCL20 protein; CCR6 protein; CD223 antigen; CD4 antigen; CD8 antigen; Cell activation; Compartments; Composition effects; CXCL10 protein; CXCR3 protein; Cytometry; Dimensional analysis; Exhaustion; Foxp3 protein; Hepatocellular carcinoma; Immune system; Immunofluorescence; Immunological memory; Immunology; Immunoregulation; Immunosuppression; Immunotherapy; Leukocytes; Liver cancer; Lymphocytes; Lymphocytes T; Macrophages; Memory cells; Natural killer cells; PD-1 protein; PNAS Plus; Proteomics; Recruitment; Tissues; Tumor cells; Tumors; regulatory T cells; tumor microenvironment; CyTOF; hepatocellular carcinoma; resident memory T cells

The recent development of immunotherapy as a cancer treatment has proved effective over recent years, but the precise dynamics between the tumor microenvironment (TME), nontumor microenvironment (NTME), and the systemic immune system remain elusive. Here, we interrogated these compartments in hepato...