Parkinson's disease pathology is directly correlated to SIRT3 in human subjects and animal models: Implications for AAV.SIRT3-myc as a disease-modifying therapy

• Published in: Neurobiology of disease Vol. 187; p. 106287
• Main Authors: Trinh, Dennison, Israwi, Ahmad R., Brar, Harsimar, Villafuerte, Jose E.A., Laylo, Ruella, Patel, Humaiyra, Jafri, Sabika, Al Halabi, Lina, Sinnathurai, Shaumia, Reehal, Kiran, Shi, Alyssa, Gnanamanogaran, Vayisnavei, Garabedian, Natalie, Pham, Ivy, Thrasher, Drake, Monnier, Philippe P., Volpicelli-Daley, Laura A., Nash, Joanne E.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.2023; Elsevier
• Subjects: Disease-modifying; Human; Mitochondria; Parkinson's disease; Rat model; Sirtuin 3; α-synuclein aggregation; α-synuclein pre-formed fibrils; Human; Rat model; Mitochondria; Parkinson's disease; Sirtuin 3; α-synuclein pre-formed fibrils; Disease-modifying; α-synuclein aggregation

In Parkinson's disease (PD), post-mortem studies in affected brain regions have demonstrated a decline in mitochondrial number and function. This combined with many studies in cell and animal models suggest that mitochondrial dysfunction is central to PD pathology. We and others have shown that...