Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma - Dayton, Talya L.; Gocheva, Vasilena; Miller, Kathryn M.; Israelsen, William J.; Bhutkar, Arjun; Clish, Clary B.; Davidson, Shawn M.; Luengo, Alba; Bronson, Roderick T.; Jacks, Tyler; Vander Heiden, Matthew G. (Genes & development, 2016)
Keywords: Animals; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - physiopathology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Proliferation - genetics; Diet, High-Fat; Embryo, Mammalian; Embryonic Development - genetics; Energy Metabolism - genetics; Female; Gene Expression Regulation, Neoplastic; Germ-Line Mutation; Growth and Development - genetics; Hepatocytes - cytology; Homeostasis - genetics; Liver Neoplasms - enzymology; Liver Neoplasms - genetics; Liver Neoplasms - physiopathology; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Protein Isoforms; Research Paper; Thyroid Hormone-Binding Proteins; Thyroid Hormones - genetics; Thyroid Hormones - metabolism; PKM2; HCC; metabolism