Extremely thermophilic microorganisms as metabolic engineering platforms for production of fuels and industrial chemicals

Enzymes from extremely thermophilic microorganisms have been of technological interest for some time because of their ability to catalyze reactions of industrial significance at elevated temperatures. Thermophilic enzymes are now routinely produced in recombinant mesophilic hosts for use as discrete...

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Published inFrontiers in microbiology Vol. 6; p. 1209
Main Authors Zeldes, Benjamin M, Keller, Matthew W, Loder, Andrew J, Straub, Christopher T, Adams, Michael W W, Kelly, Robert M
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 05.11.2015
Frontiers Media S.A
Subjects
BASIC BIOLOGICAL SCIENCES
bio-based chemicals
bio-based fuels/chemicals
Biotechnology
Extreme thermophiles
Genetics
Metabolic Engineering
Microbiology
extreme thermophiles
biotechnology
bio-based chemicals
genetics
metabolic engineering
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Abstract Enzymes from extremely thermophilic microorganisms have been of technological interest for some time because of their ability to catalyze reactions of industrial significance at elevated temperatures. Thermophilic enzymes are now routinely produced in recombinant mesophilic hosts for use as discrete biocatalysts. Genome and metagenome sequence data for extreme thermophiles provide useful information for putative biocatalysts for a wide range of biotransformations, albeit involving at most a few enzymatic steps. However, in the past several years, unprecedented progress has been made in establishing molecular genetics tools for extreme thermophiles to the point that the use of these microorganisms as metabolic engineering platforms has become possible. While in its early days, complex metabolic pathways have been altered or engineered into recombinant extreme thermophiles, such that the production of fuels and chemicals at elevated temperatures has become possible. Not only does this expand the thermal range for industrial biotechnology, it also potentially provides biodiverse options for specific biotransformations unique to these microorganisms. The list of extreme thermophiles growing optimally between 70 and 100°C with genetic toolkits currently available includes archaea and bacteria, aerobes and anaerobes, coming from genera such as Caldicellulosiruptor, Sulfolobus, Thermotoga, Thermococcus, and Pyrococcus. These organisms exhibit unusual and potentially useful native metabolic capabilities, including cellulose degradation, metal solubilization, and RuBisCO-free carbon fixation. Those looking to design a thermal bioprocess now have a host of potential candidates to choose from, each with its own advantages and challenges that will influence its appropriateness for specific applications. Here, the issues and opportunities for extremely thermophilic metabolic engineering platforms are considered with an eye toward potential technological advantages for high temperature industrial biotechnology.
AbstractList Enzymes from extremely thermophilic microorganisms have been of technological interest for some time because of their ability to catalyze reactions of industrial significance at elevated temperatures. Thermophilic enzymes are now routinely produced in recombinant mesophilic hosts for use as discrete biocatalysts. Genome and metagenome sequence data for extreme thermophiles provide useful information for putative biocatalysts for a wide range of biotransformations, albeit involving at most a few enzymatic steps. However, in the past several years, unprecedented progress has been made in establishing molecular genetics tools for extreme thermophiles to the point that the use of these microorganisms as metabolic engineering platforms has become possible. While in its early days, complex metabolic pathways have been altered or engineered into recombinant extreme thermophiles, such that the production of fuels and chemicals at elevated temperatures has become possible. Not only does this expand the thermal range for industrial biotechnology, it also potentially provides biodiverse options for specific biotransformations unique to these microorganisms. The list of extreme thermophiles growing optimally between 70 and 100°C with genetic toolkits currently available includes archaea and bacteria, aerobes and anaerobes, coming from genera such as Caldicellulosiruptor, Sulfolobus, Thermotoga, Thermococcus , and Pyrococcus . These organisms exhibit unusual and potentially useful native metabolic capabilities, including cellulose degradation, metal solubilization, and RuBisCO-free carbon fixation. Those looking to design a thermal bioprocess now have a host of potential candidates to choose from, each with its own advantages and challenges that will influence its appropriateness for specific applications. Here, the issues and opportunities for extremely thermophilic metabolic engineering platforms are considered with an eye toward potential technological advantages for high temperature industrial biotechnology.
Enzymes from extremely thermophilic microorganisms have been of technological interest for some time because of their ability to catalyze reactions of industrial significance at elevated temperatures. Thermophilic enzymes are now routinely produced in recombinant mesophilic hosts for use as discrete biocatalysts. Genome and metagenome sequence data for extreme thermophiles provide useful information for putative biocatalysts for a wide range of biotransformations, albeit involving at most a few enzymatic steps. However, in the past several years, unprecedented progress has been made in establishing molecular genetics tools for extreme thermophiles to the point that the use of these microorganisms as metabolic engineering platforms has become possible. While in its early days, complex metabolic pathways have been altered or engineered into recombinant extreme thermophiles, such that the production of fuels and chemicals at elevated temperatures has become possible. Not only does this expand the thermal range for industrial biotechnology, it also potentially provides biodiverse options for specific biotransformations unique to these microorganisms. The list of extreme thermophiles growing optimally between 70 and 100°C with genetic toolkits currently available includes archaea and bacteria, aerobes and anaerobes, coming from genera such as Caldicellulosiruptor, Sulfolobus, Thermotoga, Thermococcus, and Pyrococcus. These organisms exhibit unusual and potentially useful native metabolic capabilities, including cellulose degradation, metal solubilization, and RuBisCO-free carbon fixation. Those looking to design a thermal bioprocess now have a host of potential candidates to choose from, each with its own advantages and challenges that will influence its appropriateness for specific applications. Here, the issues and opportunities for extremely thermophilic metabolic engineering platforms are considered with an eye toward potential technological advantages for high temperature industrial biotechnology.
Enzymes from extremely thermophilic microorganisms have been of technological interest for some time because of their ability to catalyze reactions of industrial significance at elevated temperatures. Thermophilic enzymes are now routinely produced in recombinant mesophilic hosts for use as discrete biocatalysts. Genome and metagenome sequence data for extreme thermophiles provide useful information for putative biocatalysts for a wide range of biotransformations, albeit involving at most a few enzymatic steps. However, in the past several years, unprecedented progress has been made in establishing molecular genetics tools for extreme thermophiles to the point that the use of these microorganisms as metabolic engineering platforms has become possible. While in its early days, complex metabolic pathways have been altered or engineered into recombinant extreme thermophiles, such that the production of fuels and chemicals at elevated temperatures has become possible. Not only does this expand the thermal range for industrial biotechnology, it also potentially provides biodiverse options for specific biotransformations unique to these microorganisms. The list of extreme thermophiles growing optimally between 70 and 100°C with genetic toolkits currently available includes archaea and bacteria, aerobes and anaerobes, coming from genera such as Caldicellulosiruptor, Sulfolobus, Thermotoga, Thermococcus and Pyrococcus. These organisms exhibit unusual and potentially useful native metabolic capabilities, including cellulose degradation, metal solubilization, and RuBisCO-free carbon fixation. Those looking to design a thermal bioprocess now have a host of potential candidates to choose from, each with its own advantages and challenges that will influence its appropriateness for specific applications. Here, the issues and opportunities for extremely thermophilic metabolic engineering platforms are considered with an eye towards potential technological advantages for high temperature industrial biotechnology.
Author Keller, Matthew W
Straub, Christopher T
Kelly, Robert M
Loder, Andrew J
Zeldes, Benjamin M
Adams, Michael W W
AuthorAffiliation 2 Department of Biochemistry and Molecular Biology, University of Georgia Athens, GA, USA
1 Department of Chemical and Biomolecular Engineering, North Carolina State University Raleigh, NC, USA
AuthorAffiliation_xml – name: 2 Department of Biochemistry and Molecular Biology, University of Georgia Athens, GA, USA
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  organization: Department of Biochemistry and Molecular Biology, University of Georgia Athens, GA, USA
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  fullname: Loder, Andrew J
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  surname: Kelly
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  organization: Department of Chemical and Biomolecular Engineering, North Carolina State University Raleigh, NC, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26594201$$D View this record in MEDLINE/PubMed
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Copyright Copyright © 2015 Zeldes, Keller, Loder, Straub, Adams and Kelly. 2015 Zeldes, Keller, Loder, Straub, Adams and Kelly
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Keywords extreme thermophiles
biotechnology
bio-based chemicals
genetics
metabolic engineering
Language English
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US Department of Education GAANN Fellowship
National Science Foundation (NSF)
AC05-00OR22725; CBET-1264052; CBET-1264053; FA9550-13-1-0236; T32GM008776-11; P200A100004-12
National Institutes of Health (NIH)
US Air Force Office of Scientific Research (AFOSR)
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Reviewed by: Haruyuki Atomi, Kyoto University, Japan; Phillip Craig Wright, University of Sheffield, UK
Edited by: Bettina Siebers, University of Duisburg-Essen, Germany
This article was submitted to Microbiotechnology, Ecotoxicology and Bioremediation, a section of the journal Frontiers in Microbiology
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SSID ssj0000402000
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Snippet Enzymes from extremely thermophilic microorganisms have been of technological interest for some time because of their ability to catalyze reactions of...
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SubjectTerms BASIC BIOLOGICAL SCIENCES
bio-based chemicals
bio-based fuels/chemicals
Biotechnology
Extreme thermophiles
Genetics
Metabolic Engineering
Microbiology
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Title Extremely thermophilic microorganisms as metabolic engineering platforms for production of fuels and industrial chemicals
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