MAVS signaling of long-lived brain-resident myeloid cells is needed during viral encephalitis to adjust the transcriptome of CNS infiltrating CD8+ T cells - Pavlou, Andreas; Ghita, Luca; Mulenge, Felix; Waltl, Inken; Gern, Olivia Luise; Larsen, Pia-Katharina; Costa, Bibiana; Duran, Veronica; Busker, Lena Mareike; Robertson, Shelly J.; Lueder, Yvonne; Halle, Stephan; et al. (Journal of neuroinflammation, 2025)
Keywords: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Bone marrow cells; Brain - immunology; Brain - metabolism; Brain - pathology; Brain - virology; Brain infection; CD8 lymphocytes; CD8+ T cells; CD8-Positive T-Lymphocytes - metabolism; Cellular signal transduction; CNS; Cross-presentation; Development and progression; Encephalitis, Viral; Encephalitis, Viral - immunology; Encephalitis, Viral - metabolism; Encephalitis, Viral - pathology; Genetic aspects; Genetic transcription; Health aspects; MAVS signaling; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Myeloid Cells - metabolism; Signal Transduction - physiology; Transcriptome - physiology; Germany; Cross-presentation; Brain infection; CD8+ T cells; MAVS signaling; CNS; RLR signaling; Microglia