Human neutrophil lipocalin in fMLP-activated whole blood as a diagnostic means to distinguish between acute bacterial and viral infections

• Published in: Journal of immunological methods Vol. 424; pp. 85 - 90
• Main Authors: Venge, Per, Håkansson, Lena Douhan, Garwicz, Daniel, Peterson, Christer, Xu, Shengyuan, Pauksen, Karlis
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: acute course; Acute Disease; Acute infection; Adult; Aged; Bacteria; Bacterial infection; bacterial infections; Bacterial Infections - blood; Bacterial Infections - diagnosis; biomarkers; Biomarkers - blood; blood serum; enzyme-linked immunosorbent assay; Female; Human neutrophil lipocalin; Humans; Lipocalins - blood; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine - pharmacology; Neutrophil; neutrophils; Neutrophils - drug effects; Neutrophils - immunology; Neutrophils - metabolism; patients; Point-of-care; point-of-care testing; Reproducibility of Results; Sensitivity and Specificity; Viral infection; Virus Diseases - blood; Virus Diseases - diagnosis; Bacterial infection; Acute infection; Neutrophil; Human neutrophil lipocalin; Point-of-care; Viral infection

The distinction between causes of acute infections is a major clinical challenge. Current biomarkers, however, are not sufficiently accurate. Human neutrophil lipocalin (HNL) in serum distinguishes acute infections with high accuracy, but in the emergency setting the assay time should be <15–20mi...