Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia–reperfusion injury

• Published in: Neuroscience letters Vol. 504; no. 2; pp. 88 - 92
• Main Authors: Zhang, ZhenZhen, Tong, NianTin, Gong, YuanYuan, Qiu, QingHua, Yin, LiLi, Lv, XiuHong, Wu, XingWei
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 24.10.2011; Elsevier
• Subjects: Animals; Anticonvulsants - pharmacology; Anticonvulsants. Antiepileptics. Antiparkinson agents; Apoptosis - drug effects; Biological and medical sciences; Blotting, Western; Caspase 12 - metabolism; Cell Death - drug effects; CHOP; Endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Eye and associated structures. Visual pathways and centers. Vision; Fundamental and applied biological sciences. Psychology; Heat-Shock Proteins - metabolism; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylases - metabolism; Ischemia/reperfusion; Male; Medical sciences; Neuropharmacology; Neuroprotective Agents; Pharmacology. Drug treatments; Rats; Rats, Wistar; Reperfusion Injury - pathology; Retina; Retina - drug effects; Retina - ultrastructure; Retinal Ganglion Cells - drug effects; Tissue Fixation; Transcription Factor CHOP - metabolism; Valproate; Valproic Acid - pharmacology; Vertebrates: nervous system and sense organs; RGCs; IPL; VPA; INL; ORL; Retina; I/R; ER; Ischemia/reperfusion; Valproate; Endoplasmic reticulum stress; UPR; CHOP; HDAC; Anticonvulsant; Valproic acid; Stress; Eye; Visual system; Cell death; Lesion; Endoplasmic reticulum; Apoptosis

▸ Valproate (VPA), a histone deacetylase inhibitor has neuroprotective effects. ▸ VPA increased the expression of GRP78 in retina after ischemia. ▸ Hyperacetylation of histone H3 was induced by VPA in retina. ▸ VPA suppressed the upregulation of CHOP and caspase-12 in retina after ischemia. ▸ VPA re...