Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal

• Published in: Alcohol and alcoholism (Oxford) Vol. 43; no. 3; pp. 241 - 245
• Main Authors: Huang, Ming-Chyi, Chen, Chun-Hsin, Chen, Chia-Hui, Liu, Shing-Cheng, Ho, Chia-Jen, Shen, Winston W, Leu, Sy-Jye
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2008; Oxford Publishing Limited (England)
• Subjects: Adult; Alcoholism - blood; Alcoholism - diagnosis; Alcoholism - psychology; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Biomarkers - blood; Brain-Derived Neurotrophic Factor - biosynthesis; Brain-Derived Neurotrophic Factor - blood; Female; Humans; Male; Medical sciences; Middle Aged; Substance Withdrawal Syndrome - blood; Substance Withdrawal Syndrome - diagnosis; Substance Withdrawal Syndrome - psychology; Time Factors; Toxicology; Alcoholic beverage; Poison withdrawal; Ethanol; Toxicity; Disintoxication; Early; Serum; Brain derived neurotrophic factor

Aims: Alcohol withdrawal-enhanced neurotoxicity contributes to the addictive process. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity and learning. In this study, we explored the changes of serum BDNF levels in alcoholic patients at baseline and after one-week...