The Protein-Folding Problem, 50 Years On

• Published in: Science (American Association for the Advancement of Science) Vol. 338; no. 6110; pp. 1042 - 1046
• Main Authors: Dill, Ken A., MacCallum, Justin L.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 23.11.2012; The American Association for the Advancement of Science
• Subjects: Algorithms; Alzheimers disease; Amino Acid Sequence; Amino acids; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Caspase 9 - chemistry; Computer Simulation; Fundamental and applied biological sciences. Psychology; History; Modeling; Models, Chemical; Molecular and cellular biology; Molecules; Organic Chemistry; Parkinson disease; Personal computers; Pharmaceutical Preparations - chemistry; Polymers; Protein Conformation; Protein Folding; Proteins - chemistry; Proteostasis deficiencies; REVIEW; Folding; Protein

The protein-folding problem was first posed about one half-century ago. The term refers to three broad questions: (i) What is the physical code by which an amino add sequence dictates a protein's native structure? (ii) How can proteins fold so fast? (iii) Can we devise a computer algorithm to p...