Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy
Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial. PLN interacts with sarco/endoplasmic reticulum Ca -ATPase (SERCA) and regulates calcium uptake, which is modu...
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Published in | eLife Vol. 11 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
eLife Sciences Publications, Ltd
17.03.2022
eLife Sciences Publications Ltd |
Subjects | |
Online Access | Get full text |
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