The diagnostic accuracy of preimplantation genetic testing (PGT) in assessing the genetic status of embryos: a systematic review and meta-analysis

• Published in: Reproductive biology and endocrinology Vol. 23; no. 1; pp. 39 - 18
• Main Authors: Chen, Kexin, Hu, Zhixin, Lian, Yuxuan, Han, Youzhen, Zhou, Xiaoting, Li, Yonggang, Xiang, Lifeng, Jiang, Weiqun, Li, Mingying, Zeng, Peng, Zhang, Manqin, Luo, Xi, Xu, Yongfang, Zheng, Haishan, Tian, Mei, Wang, Mei, Ma, Rui, Yang, Jichun, Bai, Yun, Du, Ruiyu, Deng, Bo, Wu, Ze, Li, Yunxiu, Yan, Jiacong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.03.2025; BioMed Central; BMC
• Subjects: Biopsy; Blastocoel fluid (BF); Blastocyst; Diagnostic accuracy; Embryo; Evaluation; Female; Genetic aspects; Genetic screening; Genetic Testing - methods; Genetic Testing - standards; Humans; Inner cell mass (ICM); Medical research; Medicine, Experimental; Methods; Physiological aspects; Pregnancy; Preimplantation Diagnosis - methods; Preimplantation Diagnosis - standards; Reproducibility of Results; Review; Spent culture medium (SCM); Trophectoderm (TE) biopsy; Whole blastocyst (WB); China; Inner cell mass (ICM); Whole blastocyst (WB); Diagnostic accuracy; Spent culture medium (SCM); Blastocoel fluid (BF); Trophectoderm (TE) biopsy
• ISSN: 1477-7827; 1477-7827
• DOI: 10.1186/s12958-025-01376-1

Preimplantation genetic testing (PGT) is widely used in assisted reproduction to assess the genetic status of embryos. However, increasing evidence suggests that the trophectoderm (TE) may not fully reflect the genetic status of the inner cell mass (ICM), raising controversy about the accuracy of TE...