Mechanisms of Immunization Against Cancer Using Chimeric Antigens

• Published in: Molecular therapy Vol. 16; no. 4; pp. 773 - 781
• Main Authors: Engelhorn, Manuel E, Guevara-Patiño, José A, Merghoub, Taha, Liu, Cailian, Ferrone, Cristina R, Rizzuto, Gabriele A, Cymerman, Daniel H, Posnett, David N, Houghton, Alan N, Wolchok, Jedd D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2008; Elsevier Limited
• Subjects: ADP Ribose Transferases - genetics; ADP Ribose Transferases - immunology; Animals; Antigen Presentation; Antigens; Antigens, Neoplasm - genetics; Antigens, Neoplasm - immunology; Bacterial Outer Membrane Proteins - genetics; Bacterial Outer Membrane Proteins - immunology; Bacterial Toxins - genetics; Bacterial Toxins - immunology; Cancer; Cancer Vaccines - genetics; Cancer Vaccines - immunology; Cancer Vaccines - therapeutic use; CD8-Positive T-Lymphocytes - immunology; Chlorocebus aethiops; COS Cells; E coli; Enzymes; Escherichia coli Proteins - genetics; Escherichia coli Proteins - immunology; Exotoxins - genetics; Exotoxins - immunology; Female; Gene therapy; Herpes viruses; Histocompatibility Antigens Class II - immunology; Humans; Immune system; Immunology; Immunotherapy; Laboratories; Lymphocytes; Melanoma; Melanoma, Experimental - immunology; Melanoma, Experimental - therapy; Mice; Mice, Inbred C57BL; Polypeptides; Proteins; Pseudomonas aeruginosa Exotoxin A; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; Tumors; Vaccination; Vaccines; Vaccines, DNA - genetics; Vaccines, DNA - immunology; Vaccines, DNA - therapeutic use; Vectors (Biology); Viral Structural Proteins - genetics; Viral Structural Proteins - immunology; Virulence Factors - genetics; Virulence Factors - immunology; New York; United States > US; Massachusetts

Successful approaches to tumor immunotherapy must overcome the physiological state of tolerance of the immune system to self-tumor antigens. Immunization with appropriate variants of syngeneic antigens can achieve this. However, improvements in vaccine design are needed for efficient cancer immunoth...