Soluble Urokinase Receptor and Acute Kidney Injury

• Published in: The New England journal of medicine Vol. 382; no. 5; pp. 416 - 426
• Main Authors: Hayek, Salim S, Leaf, David E, Samman Tahhan, Ayman, Raad, Mohamad, Sharma, Shreyak, Waikar, Sushrut S, Sever, Sanja, Camacho, Alex, Wang, Xuexiang, Dande, Ranadheer R, Ibrahim, Nasrien E, Baron, Rebecca M, Altintas, Mehmet M, Wei, Changli, Sheikh-Hamad, David, Pan, Jenny S.-C, Holliday, Michael W, Januzzi, James L, Weisbord, Steven D, Quyyumi, Arshed A, Reiser, Jochen
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 30.01.2020
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - etiology; Acute Kidney Injury - prevention & control; Age; Aged; Angiography; Animals; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Bioenergetics; Biomarkers - blood; Cardiac Surgical Procedures - adverse effects; Cardiovascular disease; Coronary Angiography - adverse effects; Critical Illness; Diabetes; Disease Models, Animal; Enrollments; Female; Heart; Heart failure; Heart surgery; Humans; Intensive Care Units; Kidney diseases; Kidney Tubules - cytology; Kidney Tubules - drug effects; Kidney Tubules - pathology; Male; Medical imaging; Mice; Mice, Transgenic; Middle Aged; Mitochondria; Monoclonal antibodies; Morbidity; Odds Ratio; Patients; Plasma levels; Podocytes - drug effects; Podocytes - metabolism; Postoperative Complications - blood; Postoperative Complications - etiology; Reactive oxygen species; Receptors, Urokinase Plasminogen Activator - blood; Risk Assessment - methods; Superoxide; Therapeutic applications; Transgenic animals; Transgenic mice; U-Plasminogen activator; Urokinase-Type Plasminogen Activator - antagonists & inhibitors; Urokinase-Type Plasminogen Activator - pharmacology; Variables

Soluble urokinase plasminogen activator receptor was measured in three patient cohorts at risk for acute kidney injury. Experimental models were used to assess suPAR as a therapeutic target. High suPAR levels were associated with acute kidney injury in both clinical and experimental settings.