Association between virus exposure and depression in US adults

Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression....

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Published inPsychiatry research Vol. 261; pp. 73 - 79
Main Authors Gale, Shawn D., Berrett, Andrew N., Erickson, Lance D., Brown, Bruce L., Hedges, Dawson W.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.03.2018
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ISSN0165-1781
1872-7123
1872-7123
DOI10.1016/j.psychres.2017.12.037

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Abstract Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression. From the US Center for Disease Control's National Health and Nutrition Examination Survey, we obtained data about depression status, antidepressant use, exposure to hepatitis A, hepatitis B, herpes simplex virus type 1, herpes simplex virus type 2, human immunodeficiency virus, and cytomegalovirus, and sociodemographic variables and evaluated associations between depression and viral exposure in adjusted multivariable models. Herpes simplex virus type 2 was associated with an increased risk of depression, whereas hepatitis A, hepatitis B, and herpes simplex virus type 1 were not. Higher cytomegalovirus antibody levels were associated with depression in subjects seropositive for cytomegalovirus. In conclusion, exposure to herpes simplex virus type 2 and possibly cytomegalovirus are associated with depression in an adult US sample. •Odds of depression increase in subjects seropositive for herpes simplex-2.•Higher IgG titers for cytomegalovirus were associated with depression.•Hepatitis A and B and herpes simplex-1 were not associated with depression.
AbstractList Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression. From the US Center for Disease Control's National Health and Nutrition Examination Survey, we obtained data about depression status, antidepressant use, exposure to hepatitis A, hepatitis B, herpes simplex virus type 1, herpes simplex virus type 2, human immunodeficiency virus, and cytomegalovirus, and sociodemographic variables and evaluated associations between depression and viral exposure in adjusted multivariable models. Herpes simplex virus type 2 was associated with an increased risk of depression, whereas hepatitis A, hepatitis B, and herpes simplex virus type 1 were not. Higher cytomegalovirus antibody levels were associated with depression in subjects seropositive for cytomegalovirus. In conclusion, exposure to herpes simplex virus type 2 and possibly cytomegalovirus are associated with depression in an adult US sample.
Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression. From the US Center for Disease Control's National Health and Nutrition Examination Survey, we obtained data about depression status, antidepressant use, exposure to hepatitis A, hepatitis B, herpes simplex virus type 1, herpes simplex virus type 2, human immunodeficiency virus, and cytomegalovirus, and sociodemographic variables and evaluated associations between depression and viral exposure in adjusted multivariable models. Herpes simplex virus type 2 was associated with an increased risk of depression, whereas hepatitis A, hepatitis B, and herpes simplex virus type 1 were not. Higher cytomegalovirus antibody levels were associated with depression in subjects seropositive for cytomegalovirus. In conclusion, exposure to herpes simplex virus type 2 and possibly cytomegalovirus are associated with depression in an adult US sample.Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression. From the US Center for Disease Control's National Health and Nutrition Examination Survey, we obtained data about depression status, antidepressant use, exposure to hepatitis A, hepatitis B, herpes simplex virus type 1, herpes simplex virus type 2, human immunodeficiency virus, and cytomegalovirus, and sociodemographic variables and evaluated associations between depression and viral exposure in adjusted multivariable models. Herpes simplex virus type 2 was associated with an increased risk of depression, whereas hepatitis A, hepatitis B, and herpes simplex virus type 1 were not. Higher cytomegalovirus antibody levels were associated with depression in subjects seropositive for cytomegalovirus. In conclusion, exposure to herpes simplex virus type 2 and possibly cytomegalovirus are associated with depression in an adult US sample.
Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression. From the US Center for Disease Control's National Health and Nutrition Examination Survey, we obtained data about depression status, antidepressant use, exposure to hepatitis A, hepatitis B, herpes simplex virus type 1, herpes simplex virus type 2, human immunodeficiency virus, and cytomegalovirus, and sociodemographic variables and evaluated associations between depression and viral exposure in adjusted multivariable models. Herpes simplex virus type 2 was associated with an increased risk of depression, whereas hepatitis A, hepatitis B, and herpes simplex virus type 1 were not. Higher cytomegalovirus antibody levels were associated with depression in subjects seropositive for cytomegalovirus. In conclusion, exposure to herpes simplex virus type 2 and possibly cytomegalovirus are associated with depression in an adult US sample. •Odds of depression increase in subjects seropositive for herpes simplex-2.•Higher IgG titers for cytomegalovirus were associated with depression.•Hepatitis A and B and herpes simplex-1 were not associated with depression.
Author Berrett, Andrew N.
Erickson, Lance D.
Brown, Bruce L.
Hedges, Dawson W.
Gale, Shawn D.
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Keywords Herpes
Cytomegalovirus
NHANES
Herpes simplex type 2
Depressed mood
Viral Infection
Language English
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Snippet Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C,...
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SubjectTerms Adolescent
Adult
Antibodies, Viral - immunology
Cytomegalovirus
Depressed mood
Depression - epidemiology
Depressive Disorder, Major - epidemiology
Female
Hepatitis A - epidemiology
Hepatitis A - immunology
Hepatitis Antibodies - immunology
Hepatitis B - epidemiology
Hepatitis B - immunology
Hepatitis C - epidemiology
Hepatitis C - immunology
Herpes
Herpes Simplex - epidemiology
Herpes Simplex - immunology
Herpes simplex type 2
Herpesvirus 1, Human - immunology
Herpesvirus 2, Human - immunology
HIV Infections - epidemiology
HIV Infections - immunology
Humans
Male
Middle Aged
Multivariate Analysis
NHANES
Nutrition Surveys
United States - epidemiology
Viral Infection
Virus Diseases - epidemiology
Virus Diseases - immunology
Young Adult
Title Association between virus exposure and depression in US adults
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0165178117309800
https://dx.doi.org/10.1016/j.psychres.2017.12.037
https://www.ncbi.nlm.nih.gov/pubmed/29287239
https://www.proquest.com/docview/1982843934
Volume 261
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