Oncolytic parvoviruses as cancer therapeutics

• Published in: Cytokine & growth factor reviews Vol. 21; no. 2; pp. 185 - 195
• Main Authors: Rommelaere, Jean, Geletneky, Karsten, Angelova, Assia L, Daeffler, Laurent, Dinsart, Christiane, Kiprianova, Irina, Schlehofer, Joerg R, Raykov, Zahari
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2010; Elsevier
• Subjects: Adenocarcinoma; Advanced Basic Science; Animals; Cancer immunotherapy; Cancer virotherapy; Clinical trial; Clinical Trials as Topic; Humans; Immunologic Factors; Immunologic Factors - metabolism; Immunomodulation; Life Sciences; Microbiology and Parasitology; Neoplasms; Neoplasms - pathology; Neoplasms - therapy; Neoplasms - virology; Oncolysis; Oncolytic Virotherapy; Oncolytic Virotherapy - methods; Oncolytic Viruses; Oncosuppression; Parvovirus; Parvovirus - genetics; Parvovirus - physiology; Parvoviruses; Immunomodulation; Parvoviruses; Oncosuppression; Oncolysis; Clinical trial; Cancer immunotherapy; Cancer virotherapy

Abstract The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In pa...