Oncolytic parvoviruses as cancer therapeutics

Abstract The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In pa...

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Published inCytokine & growth factor reviews Vol. 21; no. 2; pp. 185 - 195
Main Authors Rommelaere, Jean, Geletneky, Karsten, Angelova, Assia L, Daeffler, Laurent, Dinsart, Christiane, Kiprianova, Irina, Schlehofer, Joerg R, Raykov, Zahari
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2010
Elsevier
Subjects
Adenocarcinoma
Advanced Basic Science
Animals
Cancer immunotherapy
Cancer virotherapy
Clinical trial
Clinical Trials as Topic
Humans
Immunologic Factors
Immunologic Factors - metabolism
Immunomodulation
Life Sciences
Microbiology and Parasitology
Neoplasms
Neoplasms - pathology
Neoplasms - therapy
Neoplasms - virology
Oncolysis
Oncolytic Virotherapy
Oncolytic Virotherapy - methods
Oncolytic Viruses
Oncosuppression
Parvovirus
Parvovirus - genetics
Parvovirus - physiology
Parvoviruses
Immunomodulation
Parvoviruses
Oncosuppression
Oncolysis
Clinical trial
Cancer immunotherapy
Cancer virotherapy
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Abstract Abstract The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In particular, wild-type parvovirus H-1PV can achieve a complete cure of various tumors in animal models and kill tumor cells that resist conventional anticancer treatments. There is growing evidence that H-1PV oncosuppression involves an immune component in addition to the direct viral oncolytic effect. This article summarizes the recent assessment of H-1PV antineoplastic activity in glioma, pancreatic ductal adenocarcinoma, and non-Hodgkin lymphoma models, laying the foundation for the present launch of a first phase I/IIa clinical trial on glioma patients.
AbstractList The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In particular, wild-type parvovirus H-1PV can achieve a complete cure of various tumors in animal models and kill tumor cells that resist conventional anticancer treatments. There is growing evidence that H-1PV oncosuppression involves an immune component in addition to the direct viral oncolytic effect. This article summarizes the recent assessment of H-1PV antineoplastic activity in glioma, pancreatic ductal adenocarcinoma, and non-Hodgkin lymphoma models, laying the foundation for the present launch of a first phase I/IIa clinical trial on glioma patients.
Abstract The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In particular, wild-type parvovirus H-1PV can achieve a complete cure of various tumors in animal models and kill tumor cells that resist conventional anticancer treatments. There is growing evidence that H-1PV oncosuppression involves an immune component in addition to the direct viral oncolytic effect. This article summarizes the recent assessment of H-1PV antineoplastic activity in glioma, pancreatic ductal adenocarcinoma, and non-Hodgkin lymphoma models, laying the foundation for the present launch of a first phase I/IIa clinical trial on glioma patients.
Author Schlehofer, Joerg R
Dinsart, Christiane
Kiprianova, Irina
Geletneky, Karsten
Daeffler, Laurent
Rommelaere, Jean
Angelova, Assia L
Raykov, Zahari
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  fullname: Daeffler, Laurent
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  fullname: Dinsart, Christiane
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  fullname: Kiprianova, Irina
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  fullname: Schlehofer, Joerg R
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  fullname: Raykov, Zahari
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Issue 2
Keywords Immunomodulation
Parvoviruses
Oncosuppression
Oncolysis
Clinical trial
Cancer immunotherapy
Cancer virotherapy
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Snippet Abstract The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in...
The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in...
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SubjectTerms Adenocarcinoma
Advanced Basic Science
Animals
Cancer immunotherapy
Cancer virotherapy
Clinical trial
Clinical Trials as Topic
Humans
Immunologic Factors
Immunologic Factors - metabolism
Immunomodulation
Life Sciences
Microbiology and Parasitology
Neoplasms
Neoplasms - pathology
Neoplasms - therapy
Neoplasms - virology
Oncolysis
Oncolytic Virotherapy
Oncolytic Virotherapy - methods
Oncolytic Viruses
Oncosuppression
Parvovirus
Parvovirus - genetics
Parvovirus - physiology
Parvoviruses
Title Oncolytic parvoviruses as cancer therapeutics
URI https://www.clinicalkey.es/playcontent/1-s2.0-S1359610110000225
https://dx.doi.org/10.1016/j.cytogfr.2010.02.011
https://www.ncbi.nlm.nih.gov/pubmed/20211577
https://search.proquest.com/docview/754870753
https://riip.hal.science/pasteur-00748225
Volume 21
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