Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL)
CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk. Elevated levels of Crk and CrkL have been observed in many human cancers; inhibition of Crk and CrkL expression reduced the tumor-forming potential of cancer cell lines. Despite a close rela...
Saved in:
Published in | The Journal of biological chemistry Vol. 291; no. 51; pp. 26273 - 26290 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
16.12.2016
American Society for Biochemistry and Molecular Biology |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk. Elevated levels of Crk and CrkL have been observed in many human cancers; inhibition of Crk and CrkL expression reduced the tumor-forming potential of cancer cell lines. Despite a close relationship between the Crk family proteins and tumorigenesis, how Crk and CrkL contribute to cell growth is unclear. We ablated endogenous Crk and CrkL from cultured fibroblasts carrying floxed alleles of Crk and CrkL by transfection with synthetic Cre mRNA (synCre). Loss of Crk and CrkL induced by synCre transfection blocked cell proliferation and caused shrinkage of the cytoplasm and the nucleus, formation of adherens junctions, and reduced cell motility. Ablation of Crk or CrkL alone conferred a much more modest reduction in cell proliferation. Reintroduction of CrkI, CrkII, or CrkL individually rescued cell proliferation in the absence of the endogenous Crk and CrkL, suggesting that Crk and CrkL play overlapping functions in regulating fibroblast growth. Serum and basic FGF induced phosphorylation of Akt, MAP kinases, and S6 kinase and Fos expression in the absence of Crk and CrkL, suggesting that cells lacking Crk and CrkL are capable of initiating major signal transduction pathways in response to extracellular stimuli. Furthermore, cell cycle and cell death analyses demonstrated that fibroblasts lacking Crk and CrkL become arrested at the G1-S transition and undergo a modest apoptosis. Taken together, our results suggest that Crk and CrkL play essential overlapping roles in fibroblast growth. |
---|---|
AbstractList | CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene
v-Crk
. Elevated levels of Crk and CrkL have been observed in many human cancers; inhibition of Crk and CrkL expression reduced the tumor-forming potential of cancer cell lines. Despite a close relationship between the Crk family proteins and tumorigenesis, how Crk and CrkL contribute to cell growth is unclear. We ablated endogenous
Crk
and
CrkL
from cultured fibroblasts carrying floxed alleles of
Crk
and
CrkL
by transfection with synthetic Cre mRNA (
synCre
). Loss of Crk and CrkL induced by
synCre
transfection blocked cell proliferation and caused shrinkage of the cytoplasm and the nucleus, formation of adherens junctions, and reduced cell motility. Ablation of
Crk
or
CrkL
alone conferred a much more modest reduction in cell proliferation. Reintroduction of
CrkI
,
CrkII
, or
CrkL
individually rescued cell proliferation in the absence of the endogenous Crk and CrkL, suggesting that Crk and CrkL play overlapping functions in regulating fibroblast growth. Serum and basic FGF induced phosphorylation of Akt, MAP kinases, and S6 kinase and Fos expression in the absence of Crk and CrkL, suggesting that cells lacking Crk and CrkL are capable of initiating major signal transduction pathways in response to extracellular stimuli. Furthermore, cell cycle and cell death analyses demonstrated that fibroblasts lacking Crk and CrkL become arrested at the G
1
-S transition and undergo a modest apoptosis. Taken together, our results suggest that Crk and CrkL play essential overlapping roles in fibroblast growth. CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk Elevated levels of Crk and CrkL have been observed in many human cancers; inhibition of Crk and CrkL expression reduced the tumor-forming potential of cancer cell lines. Despite a close relationship between the Crk family proteins and tumorigenesis, how Crk and CrkL contribute to cell growth is unclear. We ablated endogenous Crk and CrkL from cultured fibroblasts carrying floxed alleles of Crk and CrkL by transfection with synthetic Cre mRNA (synCre). Loss of Crk and CrkL induced by synCre transfection blocked cell proliferation and caused shrinkage of the cytoplasm and the nucleus, formation of adherens junctions, and reduced cell motility. Ablation of Crk or CrkL alone conferred a much more modest reduction in cell proliferation. Reintroduction of CrkI, CrkII, or CrkL individually rescued cell proliferation in the absence of the endogenous Crk and CrkL, suggesting that Crk and CrkL play overlapping functions in regulating fibroblast growth. Serum and basic FGF induced phosphorylation of Akt, MAP kinases, and S6 kinase and Fos expression in the absence of Crk and CrkL, suggesting that cells lacking Crk and CrkL are capable of initiating major signal transduction pathways in response to extracellular stimuli. Furthermore, cell cycle and cell death analyses demonstrated that fibroblasts lacking Crk and CrkL become arrested at the G -S transition and undergo a modest apoptosis. Taken together, our results suggest that Crk and CrkL play essential overlapping roles in fibroblast growth. CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk. Elevated levels of Crk and CrkL have been observed in many human cancers; inhibition of Crk and CrkL expression reduced the tumor-forming potential of cancer cell lines. Despite a close relationship between the Crk family proteins and tumorigenesis, how Crk and CrkL contribute to cell growth is unclear. We ablated endogenous Crk and CrkL from cultured fibroblasts carrying floxed alleles of Crk and CrkL by transfection with synthetic Cre mRNA (synCre). Loss of Crk and CrkL induced by synCre transfection blocked cell proliferation and caused shrinkage of the cytoplasm and the nucleus, formation of adherens junctions, and reduced cell motility. Ablation of Crk or CrkL alone conferred a much more modest reduction in cell proliferation. Reintroduction of CrkI, CrkII, or CrkL individually rescued cell proliferation in the absence of the endogenous Crk and CrkL, suggesting that Crk and CrkL play overlapping functions in regulating fibroblast growth. Serum and basic FGF induced phosphorylation of Akt, MAP kinases, and S6 kinase and Fos expression in the absence of Crk and CrkL, suggesting that cells lacking Crk and CrkL are capable of initiating major signal transduction pathways in response to extracellular stimuli. Furthermore, cell cycle and cell death analyses demonstrated that fibroblasts lacking Crk and CrkL become arrested at the G1-S transition and undergo a modest apoptosis. Taken together, our results suggest that Crk and CrkL play essential overlapping roles in fibroblast growth. |
Author | Park, Taeju Koptyra, Mateusz Curran, Tom |
Author_xml | – sequence: 1 givenname: Taeju orcidid: 0000-0003-3897-3994 surname: Park fullname: Park, Taeju email: tjpark@cmh.edu – sequence: 2 givenname: Mateusz orcidid: 0000-0002-3857-6633 surname: Koptyra fullname: Koptyra, Mateusz – sequence: 3 givenname: Tom orcidid: 0000-0003-1444-7551 surname: Curran fullname: Curran, Tom |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27807028$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kE1LAzEQhoNUbK2evcke9bB1kv1IchFk0Sq2CFLBW8hmsza63dRkq_jvTVkVPZjLZGbeeYd59tGgta1G6AjDBANNz55LNZljnE9onuY42UEjDCyJkww_DtAIgOCYk4wN0b73zxBeyvEeGhLKgAJhIzS_MqWzZSN9F02dfe-W0b1-3RinfVQsMITsadPIzrrI1tGtaaXX0UnhXk4j2VZR-MSNeelLs9MDtFvLxuvDrzhGD1eXi-I6nt1Nb4qLWaxSxrs4o6Ws6jyFMgNKmeScJAmjuATOqQJGas4o1TghJU9JDTmWOZcZQKYrmdYqGaPz3ne9KVe6UrrtnGzE2pmVdB_CSiP-dlqzFE_2TWQ44wFBMDjrDZSz3jtd_8xiEFuyIpAVW7KiJxsmjn-v_NF_owwC3gt0OPzNaCe8MrpVugowVScqa_41_wQ754gV |
CitedBy_id | crossref_primary_10_1186_s13046_020_01559_1 crossref_primary_10_3390_cells10040739 crossref_primary_10_1091_mbc_E19_05_0302 crossref_primary_10_18632_oncotarget_27509 crossref_primary_10_1038_s41584_020_0469_2 crossref_primary_10_3390_cells12030422 crossref_primary_10_1016_j_jbc_2021_100390 crossref_primary_10_1111_jcmm_16303 crossref_primary_10_1093_hmg_ddab313 crossref_primary_10_1039_C7MD00619E crossref_primary_10_3389_fmolb_2020_00223 crossref_primary_10_1016_j_gee_2021_02_006 crossref_primary_10_1016_j_yexcr_2020_112135 crossref_primary_10_2147_COPD_S422508 |
Cites_doi | 10.1038/nmeth.2019 10.1177/1947601912458687 10.1101/gad.1977710 10.1242/jcs.054627 10.1083/jcb.200208140 10.1007/s12032-015-0494-1 10.1016/j.stem.2010.08.012 10.1091/mbc.9.11.3179 10.1016/j.cyto.2015.05.009 10.1002/mc.20745 10.1073/pnas.201415498 10.1002/mc.22262 10.2174/156652312802762536 10.1038/sj.onc.1206529 10.1111/cas.12662 10.1016/j.bbrc.2011.12.142 10.1002/jcb.21829 10.1006/excr.2002.5504 10.1074/jbc.271.38.23255 10.1177/1947601912459951 10.1007/s13277-014-2724-0 10.1128/MCB.22.13.4929-4942.2002 10.1172/JCI77278 10.1158/1541-7786.MCR-04-0211 10.1016/S0304-3835(01)00763-7 10.1074/jbc.275.17.12667 10.1073/pnas.161269798 10.1016/j.it.2008.04.006 10.1002/jcb.24749 10.1074/jbc.273.6.3408 10.1093/emboj/16.10.2634 10.1016/j.canlet.2011.01.004 10.1161/01.HYP.0000069698.11814.F4 10.1182/blood-2005-04-1388 10.1186/1478-811X-7-13 10.1523/JNEUROSCI.4323-08.2008 10.1016/S0896-6273(02)00582-2 10.1091/mbc.01-10-0477 10.1002/mc.21935 10.1158/1541-7786.MCR-05-0141 10.1016/j.bbrc.2007.08.106 10.1038/sj.emboj.7600417 10.1073/pnas.94.6.2356 10.1038/ki.2013.556 10.1038/onc.2012.590 10.1038/onc.2013.453 10.1101/SQB.1988.053.01.104 10.1038/sj.onc.1209398 10.1128/MCB.00472-06 10.1016/j.ejphar.2011.12.018 10.18632/oncotarget.8314 10.1007/s10585-011-9378-8 10.1038/sj.onc.1203977 10.1016/j.cbi.2013.09.003 10.1139/y02-101 10.1186/bcr3183 10.1177/1947601910397188 |
ContentType | Journal Article |
Copyright | 2016 © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2016 by The American Society for Biochemistry and Molecular Biology, Inc. 2016 by The American Society for Biochemistry and Molecular Biology, Inc. 2016 The American Society for Biochemistry and Molecular Biology, Inc. |
Copyright_xml | – notice: 2016 © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. – notice: 2016 by The American Society for Biochemistry and Molecular Biology, Inc. – notice: 2016 by The American Society for Biochemistry and Molecular Biology, Inc. 2016 The American Society for Biochemistry and Molecular Biology, Inc. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
DOI | 10.1074/jbc.M116.764613 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Chemistry |
DocumentTitleAlternate | Crk and CrkL Control Fibroblast Growth |
EISSN | 1083-351X |
EndPage | 26290 |
ExternalDocumentID | 10_1074_jbc_M116_764613 27807028 S0021925820344513 |
Genre | Journal Article |
GroupedDBID | --- -DZ -ET -~X 0SF 18M 29J 2WC 34G 39C 4.4 53G 5BI 5GY 5RE 5VS 6I. 79B 85S AAEDW AAFTH AAFWJ AARDX AAXUO ABDNZ ABOCM ABPPZ ABRJW ACGFO ACNCT ADBBV ADIYS ADNWM AENEX AEXQZ AFOSN AFPKN ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BTFSW CJ0 CS3 DIK DU5 E3Z EBS EJD F5P FDB FRP GROUPED_DOAJ GX1 HH5 HYE IH2 KQ8 L7B N9A OK1 P0W P2P R.V RHF RHI RNS ROL RPM SJN TBC TN5 TR2 UHB UKR UPT VQA W8F WH7 WOQ XSW YQT YSK YWH YZZ ZA5 ~02 ~KM 0R~ AALRI ADVLN AITUG AKRWK CGR CUY CVF ECM EIF H13 NPM .55 .GJ 186 3O- 41~ 6TJ AAYJJ AAYOK AAYXX ABFSI ABTAH ACSFO ACYGS AFFNX AI. C1A CITATION E.L F20 FA8 J5H MVM NHB OHT P-O QZG UQL VH1 WHG X7M XJT Y6R YYP ZE2 ZGI ZY4 5PM |
ID | FETCH-LOGICAL-c489t-57badf640b50778a99233871b0997c082f9877e132b942f061a69a5005eda4fc3 |
IEDL.DBID | RPM |
ISSN | 0021-9258 |
IngestDate | Tue Sep 17 21:20:19 EDT 2024 Fri Aug 23 00:39:55 EDT 2024 Sat Sep 28 08:39:24 EDT 2024 Fri Feb 23 02:45:26 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 51 |
Keywords | growth factor fibroblast cell cycle adaptor protein cell growth apoptosis serum |
Language | English |
License | This is an open access article under the CC BY license. 2016 by The American Society for Biochemistry and Molecular Biology, Inc. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c489t-57badf640b50778a99233871b0997c082f9877e132b942f061a69a5005eda4fc3 |
Notes | Edited by Xiao-Fan Wang |
ORCID | 0000-0003-3897-3994 0000-0002-3857-6633 0000-0003-1444-7551 |
OpenAccessLink | https://dx.doi.org/10.1074/jbc.M116.764613 |
PMID | 27807028 |
PageCount | 18 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5159491 crossref_primary_10_1074_jbc_M116_764613 pubmed_primary_27807028 elsevier_sciencedirect_doi_10_1074_jbc_M116_764613 |
PublicationCentury | 2000 |
PublicationDate | 2016-12-16 |
PublicationDateYYYYMMDD | 2016-12-16 |
PublicationDate_xml | – month: 12 year: 2016 text: 2016-12-16 day: 16 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: 11200 Rockville Pike, Suite 302, Rockville, MD 20852-3110, U.S.A |
PublicationTitle | The Journal of biological chemistry |
PublicationTitleAlternate | J Biol Chem |
PublicationYear | 2016 |
Publisher | Elsevier Inc American Society for Biochemistry and Molecular Biology |
Publisher_xml | – name: Elsevier Inc – name: American Society for Biochemistry and Molecular Biology |
References | Huang, Chen, Ingber (bib46) 1998; 9 Miller, Chen, Gharib, Wang, Thomas, Misek, Giordano, Yee, Orringer, Hanash, Beer (bib8) 2003; 22 Cheng, Guo, Yang, Han (bib52) 2015; 36 Han, Wu, Yang, Li, Zhang, Li (bib55) 2015; 76 Park, Boyd, Curran (bib58) 2006; 26 Schindelin, Arganda-Carreras, Frise, Kaynig, Longair, Pietzsch, Preibisch, Rueden, Saalfeld, Schmid, Tinevez, White, Hartenstein, Eliceiri, Tomancak, Cardona (bib59) 2012; 9 Bell, Park (bib30) 2012; 3 Wang, Dong, Fu, Stoecker, Wang, Wang (bib9) 2013; 52 Wang, Che, Li, Liu, Shen, Wang, Linghu (bib6) 2011; 50 Watanabe, Tsuda, Makino, Ichihara, Sawa, Minami, Mochizuki, Nagashima, Tanaka (bib16) 2006; 4 Wang, Chen, Li, Su, Yu, Cai, Li, Yu, Liu, Zhu (bib12) 2013; 206 Rodrigues, Park, Schlessinger (bib39) 1997; 16 Lamorte, Kamikura, Park (bib38) 2000; 19 Rodrigues, Fathers, Chan, Zuo, Halwani, Meterissian, Park (bib11) 2005; 3 Mortazavi, Dubinett, Rettig (bib27) 2011; 28 Linghu, Tsuda, Makino, Sakai, Watanabe, Ichihara, Sawa, Nagashima, Mochizuki, Tanaka (bib15) 2006; 25 Warren, Manos, Ahfeldt, Loh, Li, Lau, Ebina, Mandal, Smith, Meissner, Daley, Brack, Collins, Cowan, Schlaeger, Rossi (bib23) 2010; 7 Loonstra, Vooijs, Beverloo, Allak, van Drunen, Kanaar, Berns, Jonkers (bib28) 2001; 98 Lamorte, Royal, Naujokas, Park (bib26) 2002; 13 Magdaleno, Keshvara, Curran (bib53) 2002; 33 Fathers, Bell, Rajadurai, Cory, Zhao, Mourskaia, Zuo, Madore, Monast, Mes-Masson, Grosset, Gaboury, Hallet, Siegel, Park (bib10) 2012; 14 Wang, Tabu, Kimura, Tsuda, Linghu, Tanino, Kaneko, Nishihara, Tanaka (bib14) 2007; 362 Cheng, Guo, Yang, Yang (bib54) 2015; 32 Isakov (bib31) 2008; 29 Sriram, Birge (bib19) 2010; 1 Mochizuki, Ohba, Kobayashi, Otsuka, Graybiel, Tanaka, Matsuda (bib36) 2000; 275 Takino, Nakada, Miyamori, Yamashita, Yamada, Sato (bib13) 2003; 63 Park, Curran (bib21) 2014; 33 Park, Curran (bib51) 2008; 28 Koptyra, Park, Curran (bib22) 2016; 55 Mayer, Hamaguchi, Hanafusa (bib1) 1988; 53 Senechal, Halpern, Sawyers (bib4) 1996; 271 Birge, Kalodimos, Inagaki, Tanaka (bib32) 2009; 7 Kumar, Fajardo, Birge, Sriram (bib2) 2014; 115 Lohez, Reynaud, Borel, Andreassen, Margolis (bib47) 2003; 161 Lei, Nimnual, Zong, Kennedy, Flavell, Thompson, Bar-Sagi, Davis (bib40) 2002; 22 Elmansuri, Tanino, Mahabir, Wang, Kimura, Nishihara, Kinoshita, Dosaka-Akita, Tsuda, Tanaka (bib57) 2016; 7 Paski, Xu (bib41) 2002; 80 Yanagi, Wang, Nishihara, Kimura, Tanino, Yanagi, Fukuda, Tanaka (bib17) 2012; 418 Li, Liu, Ouyang, Fan, Wang, Zhang, Zeng, Chai, Wang (bib43) 2012; 678 Nishihara, Tanaka, Tsuda, Oikawa, Maeda, Shimizu, Shinomiya, Tanigami, Sawa, Nagashima (bib7) 2002; 180 Batt, Roberts (bib25) 1998; 273 Huang, Clarke, Karimi, Roy, Williamson, Okumura, Mochizuki, Chen, Park, Debes, Zhang, Curran, Kambayashi, Burkhardt (bib50) 2015; 125 Yeung, Ngo, Grohar, Arnaldez, Asante, Wan, Khan, Hewitt, Khanna, Staudt, Helman (bib18) 2013; 32 Hallock, Xu, Park, Neubert, Curran, Burden (bib49) 2010; 24 Deng, Zhang, Riedel (bib42) 2008; 105 Huang, Ingber (bib45) 2002; 275 Yamada, Yanamoto, Kawasaki, Rokutanda, Yonezawa, Kawakita, Nemoto (bib5) 2011; 303 Kodama, Fukuda, Takahashi, Tahara, Tomita, Ieda, Kimura, Owada, Vuori, Ogawa (bib33) 2003; 41 Matsumoto, Tsuda, Wang, Maishi, Abe, Kimura, Tanino, Nishihara, Hida, Ohba, Shinohara, Nonomura, Tanaka (bib56) 2015; 106 Matsuda, Tanaka, Nagata, Kojima, Kurata, Shibuya (bib3) 1992; 12 Kuhn, Beiβert, Simon, Vallazza, Buck, Davies, Tureci, Sahin (bib24) 2012; 12 Antoku, Mayer (bib44) 2009; 122 Pfeifer, Brandon, Kootstra, Gage, Verma (bib29) 2001; 98 George, Fan, Dlugos, Soofi, Zhang, Verma, Park, Wong, Curran, Nihalani, Holzman (bib48) 2014; 85 Tanaka, Ouchi, Hanafusa (bib37) 1997; 94 Ishimaru, Ueda, Hinohara, Ohtani, Hanafusa (bib35) 2004; 23 Tsuda, Tanaka (bib20) 2012; 3 Salameh, Galvagni, Bardelli, Bussolino, Oliviero (bib34) 2005; 106 Isakov (10.1074/jbc.M116.764613_bib31) 2008; 29 Pfeifer (10.1074/jbc.M116.764613_bib29) 2001; 98 Watanabe (10.1074/jbc.M116.764613_bib16) 2006; 4 Kodama (10.1074/jbc.M116.764613_bib33) 2003; 41 Mortazavi (10.1074/jbc.M116.764613_bib27) 2011; 28 Kuhn (10.1074/jbc.M116.764613_bib24) 2012; 12 Park (10.1074/jbc.M116.764613_bib51) 2008; 28 Cheng (10.1074/jbc.M116.764613_bib54) 2015; 32 Rodrigues (10.1074/jbc.M116.764613_bib39) 1997; 16 Tanaka (10.1074/jbc.M116.764613_bib37) 1997; 94 Lohez (10.1074/jbc.M116.764613_bib47) 2003; 161 Kumar (10.1074/jbc.M116.764613_bib2) 2014; 115 Yamada (10.1074/jbc.M116.764613_bib5) 2011; 303 Han (10.1074/jbc.M116.764613_bib55) 2015; 76 Matsuda (10.1074/jbc.M116.764613_bib3) 1992; 12 Loonstra (10.1074/jbc.M116.764613_bib28) 2001; 98 Nishihara (10.1074/jbc.M116.764613_bib7) 2002; 180 George (10.1074/jbc.M116.764613_bib48) 2014; 85 Huang (10.1074/jbc.M116.764613_bib45) 2002; 275 Lei (10.1074/jbc.M116.764613_bib40) 2002; 22 Elmansuri (10.1074/jbc.M116.764613_bib57) 2016; 7 Wang (10.1074/jbc.M116.764613_bib6) 2011; 50 Salameh (10.1074/jbc.M116.764613_bib34) 2005; 106 Mochizuki (10.1074/jbc.M116.764613_bib36) 2000; 275 Warren (10.1074/jbc.M116.764613_bib23) 2010; 7 Birge (10.1074/jbc.M116.764613_bib32) 2009; 7 Park (10.1074/jbc.M116.764613_bib58) 2006; 26 Batt (10.1074/jbc.M116.764613_bib25) 1998; 273 Fathers (10.1074/jbc.M116.764613_bib10) 2012; 14 Miller (10.1074/jbc.M116.764613_bib8) 2003; 22 Lamorte (10.1074/jbc.M116.764613_bib26) 2002; 13 Bell (10.1074/jbc.M116.764613_bib30) 2012; 3 Huang (10.1074/jbc.M116.764613_bib50) 2015; 125 Sriram (10.1074/jbc.M116.764613_bib19) 2010; 1 Magdaleno (10.1074/jbc.M116.764613_bib53) 2002; 33 Wang (10.1074/jbc.M116.764613_bib12) 2013; 206 Koptyra (10.1074/jbc.M116.764613_bib22) 2016; 55 Paski (10.1074/jbc.M116.764613_bib41) 2002; 80 Yanagi (10.1074/jbc.M116.764613_bib17) 2012; 418 Deng (10.1074/jbc.M116.764613_bib42) 2008; 105 Huang (10.1074/jbc.M116.764613_bib46) 1998; 9 Park (10.1074/jbc.M116.764613_bib21) 2014; 33 Yeung (10.1074/jbc.M116.764613_bib18) 2013; 32 Antoku (10.1074/jbc.M116.764613_bib44) 2009; 122 Cheng (10.1074/jbc.M116.764613_bib52) 2015; 36 Matsumoto (10.1074/jbc.M116.764613_bib56) 2015; 106 Schindelin (10.1074/jbc.M116.764613_bib59) 2012; 9 Linghu (10.1074/jbc.M116.764613_bib15) 2006; 25 Takino (10.1074/jbc.M116.764613_bib13) 2003; 63 Wang (10.1074/jbc.M116.764613_bib9) 2013; 52 Lamorte (10.1074/jbc.M116.764613_bib38) 2000; 19 Mayer (10.1074/jbc.M116.764613_bib1) 1988; 53 Wang (10.1074/jbc.M116.764613_bib14) 2007; 362 Hallock (10.1074/jbc.M116.764613_bib49) 2010; 24 Senechal (10.1074/jbc.M116.764613_bib4) 1996; 271 Rodrigues (10.1074/jbc.M116.764613_bib11) 2005; 3 Tsuda (10.1074/jbc.M116.764613_bib20) 2012; 3 Ishimaru (10.1074/jbc.M116.764613_bib35) 2004; 23 Li (10.1074/jbc.M116.764613_bib43) 2012; 678 |
References_xml | – volume: 275 start-page: 12667 year: 2000 end-page: 12671 ident: bib36 article-title: Crk activation of JNK via C3G and R-Ras publication-title: J. Biol. Chem contributor: fullname: Matsuda – volume: 80 start-page: 790 year: 2002 end-page: 795 ident: bib41 article-title: Growth factor stimulated cell proliferation is accompanied by an elevated labile intracellular pool of zinc in 3T3 cells publication-title: Can. J. Physiol. Pharmacol contributor: fullname: Xu – volume: 28 start-page: 391 year: 2011 end-page: 404 ident: bib27 article-title: c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells publication-title: Clin. Exp. Metastasis contributor: fullname: Rettig – volume: 41 start-page: 1372 year: 2003 end-page: 1379 ident: bib33 article-title: Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation publication-title: Hypertension contributor: fullname: Ogawa – volume: 3 start-page: 183 year: 2005 end-page: 194 ident: bib11 article-title: CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells publication-title: Mol. Cancer Res contributor: fullname: Park – volume: 115 start-page: 819 year: 2014 end-page: 825 ident: bib2 article-title: Crk at the quarter century mark: perspectives in signaling and cancer publication-title: J. Cell. Biochem contributor: fullname: Sriram – volume: 63 start-page: 2335 year: 2003 end-page: 2337 ident: bib13 article-title: CrkI adapter protein modulates cell migration and invasion in glioblastoma publication-title: Cancer Res contributor: fullname: Sato – volume: 85 start-page: 1382 year: 2014 end-page: 1394 ident: bib48 article-title: Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis publication-title: Kidney Int contributor: fullname: Holzman – volume: 106 start-page: 3423 year: 2005 end-page: 3431 ident: bib34 article-title: Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways publication-title: Blood contributor: fullname: Oliviero – volume: 180 start-page: 55 year: 2002 end-page: 61 ident: bib7 article-title: Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers publication-title: Cancer Lett contributor: fullname: Nagashima – volume: 29 start-page: 388 year: 2008 end-page: 396 ident: bib31 article-title: A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling publication-title: Trends Immunol contributor: fullname: Isakov – volume: 94 start-page: 2356 year: 1997 end-page: 2361 ident: bib37 article-title: Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G publication-title: Proc. Natl. Acad. Sci. U.S.A contributor: fullname: Hanafusa – volume: 106 start-page: 709 year: 2015 end-page: 717 ident: bib56 article-title: Adaptor protein CRK induces epithelial-mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop publication-title: Cancer Sci contributor: fullname: Tanaka – volume: 53 start-page: 907 year: 1988 end-page: 914 ident: bib1 article-title: Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C publication-title: Cold Spring Harb. Symp. Quant. Biol contributor: fullname: Hanafusa – volume: 19 start-page: 5973 year: 2000 end-page: 5981 ident: bib38 article-title: A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein publication-title: Oncogene contributor: fullname: Park – volume: 303 start-page: 84 year: 2011 end-page: 91 ident: bib5 article-title: Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma publication-title: Cancer Lett contributor: fullname: Nemoto – volume: 98 start-page: 9209 year: 2001 end-page: 9214 ident: bib28 article-title: Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells publication-title: Proc. Natl. Acad. Sci. U.S.A contributor: fullname: Jonkers – volume: 24 start-page: 2451 year: 2010 end-page: 2461 ident: bib49 article-title: Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L publication-title: Genes Dev contributor: fullname: Burden – volume: 125 start-page: 1019 year: 2015 end-page: 1032 ident: bib50 article-title: CRK proteins selectively regulate T cell migration into inflamed tissues publication-title: J. Clin. Invest contributor: fullname: Burkhardt – volume: 7 start-page: 618 year: 2010 end-page: 630 ident: bib23 article-title: Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA publication-title: Cell Stem Cell contributor: fullname: Rossi – volume: 7 start-page: 13 year: 2009 ident: bib32 article-title: Crk and CrkL adaptor proteins: networks for physiological and pathological signaling publication-title: Cell Commun. Signal contributor: fullname: Tanaka – volume: 32 start-page: 47 year: 2015 ident: bib54 article-title: Crk-like adapter protein regulates CCL19/CCR7-mediated epithelial-to-mesenchymal transition via ERK signaling pathway in epithelial ovarian carcinomas publication-title: Med. Oncol contributor: fullname: Yang – volume: 55 start-page: 97 year: 2016 end-page: 104 ident: bib22 article-title: Crk and CrkL are required for cell transformation by v-fos and v-ras publication-title: Mol Carcinog contributor: fullname: Curran – volume: 362 start-page: 976 year: 2007 end-page: 981 ident: bib14 article-title: Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4 publication-title: Biochem. Biophys. Res. Commun contributor: fullname: Tanaka – volume: 1 start-page: 1132 year: 2010 end-page: 1139 ident: bib19 article-title: Emerging roles for crk in human cancer publication-title: Genes Cancer contributor: fullname: Birge – volume: 9 start-page: 3179 year: 1998 end-page: 3193 ident: bib46 article-title: Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension publication-title: Mol. Biol. Cell contributor: fullname: Ingber – volume: 32 start-page: 5429 year: 2013 end-page: 5438 ident: bib18 article-title: Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth publication-title: Oncogene contributor: fullname: Helman – volume: 3 start-page: 341 year: 2012 end-page: 352 ident: bib30 article-title: Models of crk adaptor proteins in cancer publication-title: Genes Cancer contributor: fullname: Park – volume: 33 start-page: 5121 year: 2014 end-page: 5132 ident: bib21 article-title: Essential roles of Crk and CrkL in fibroblast structure and motility publication-title: Oncogene contributor: fullname: Curran – volume: 4 start-page: 499 year: 2006 end-page: 510 ident: bib16 article-title: Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines publication-title: Mol Cancer Res contributor: fullname: Tanaka – volume: 98 start-page: 11450 year: 2001 end-page: 11455 ident: bib29 article-title: Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting publication-title: Proc. Natl. Acad. Sci. U.S.A contributor: fullname: Verma – volume: 418 start-page: 104 year: 2012 end-page: 109 ident: bib17 article-title: CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion publication-title: Biochem. Biophys. Res. Commun contributor: fullname: Tanaka – volume: 105 start-page: 1172 year: 2008 end-page: 1182 ident: bib42 article-title: Mitogenic roles of Gab1 and Grb10 as direct cellular partners in the regulation of MAP kinase signaling publication-title: J. Cell. Biochem contributor: fullname: Riedel – volume: 25 start-page: 3547 year: 2006 end-page: 3556 ident: bib15 article-title: Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS publication-title: Oncogene contributor: fullname: Tanaka – volume: 12 start-page: 347 year: 2012 end-page: 361 ident: bib24 article-title: mRNA as a versatile tool for exogenous protein expression publication-title: Curr. Gene Ther contributor: fullname: Sahin – volume: 13 start-page: 1449 year: 2002 end-page: 1461 ident: bib26 article-title: Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions publication-title: Mol. Biol. Cell contributor: fullname: Park – volume: 3 start-page: 334 year: 2012 end-page: 340 ident: bib20 article-title: Roles for crk in cancer metastasis and invasion publication-title: Genes Cancer contributor: fullname: Tanaka – volume: 271 start-page: 23255 year: 1996 end-page: 23261 ident: bib4 article-title: The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene publication-title: J. Biol. Chem contributor: fullname: Sawyers – volume: 122 start-page: 4228 year: 2009 end-page: 4238 ident: bib44 article-title: Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals publication-title: J. Cell Sci contributor: fullname: Mayer – volume: 33 start-page: 573 year: 2002 end-page: 586 ident: bib53 article-title: Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice publication-title: Neuron contributor: fullname: Curran – volume: 206 start-page: 230 year: 2013 end-page: 238 ident: bib12 article-title: CRKL promotes cell proliferation in gastric cancer and is negatively regulated by miR-126 publication-title: Chem. Biol. Interact contributor: fullname: Zhu – volume: 678 start-page: 1 year: 2012 end-page: 5 ident: bib43 article-title: Effect of celecoxib on proliferation, collagen expression, ERK1/2 and SMAD2/3 phosphorylation in NIH/3T3 fibroblasts publication-title: Eur. J. Pharmacol contributor: fullname: Wang – volume: 7 start-page: 27094 year: 2016 end-page: 27107 ident: bib57 article-title: Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer publication-title: Oncotarget contributor: fullname: Tanaka – volume: 36 start-page: 915 year: 2015 end-page: 919 ident: bib52 article-title: Crk-like adapter protein is required for TGF-β-induced AKT and ERK-signaling pathway in epithelial ovarian carcinomas publication-title: Tumour Biol contributor: fullname: Han – volume: 14 start-page: R74 year: 2012 ident: bib10 article-title: Crk adaptor proteins act as key signaling integrators for breast tumorigenesis publication-title: Breast Cancer Res contributor: fullname: Park – volume: 161 start-page: 67 year: 2003 end-page: 77 ident: bib47 article-title: Arrest of mammalian fibroblasts in G publication-title: J. Cell Biol contributor: fullname: Margolis – volume: 275 start-page: 255 year: 2002 end-page: 264 ident: bib45 article-title: A discrete cell cycle checkpoint in late G publication-title: Exp. Cell Res contributor: fullname: Ingber – volume: 52 start-page: 890 year: 2013 end-page: 899 ident: bib9 article-title: Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer publication-title: Mol Carcinog contributor: fullname: Wang – volume: 273 start-page: 3408 year: 1998 end-page: 3414 ident: bib25 article-title: Cell density modulates protein-tyrosine phosphorylation publication-title: J. Biol. Chem contributor: fullname: Roberts – volume: 16 start-page: 2634 year: 1997 end-page: 2645 ident: bib39 article-title: Activation of the JNK pathway is essential for transformation by the Met oncogene publication-title: EMBO J contributor: fullname: Schlessinger – volume: 28 start-page: 13551 year: 2008 end-page: 13562 ident: bib51 article-title: Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway publication-title: J. Neurosci contributor: fullname: Curran – volume: 50 start-page: 506 year: 2011 end-page: 515 ident: bib6 article-title: Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma publication-title: Mol. Carcinog contributor: fullname: Linghu – volume: 26 start-page: 6272 year: 2006 end-page: 6282 ident: bib58 article-title: Cardiovascular and craniofacial defects in Crk-null mice publication-title: Mol. Cell. Biol contributor: fullname: Curran – volume: 22 start-page: 4929 year: 2002 end-page: 4942 ident: bib40 article-title: The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH publication-title: Mol. Cell. Biol contributor: fullname: Davis – volume: 12 start-page: 3482 year: 1992 end-page: 3489 ident: bib3 article-title: Two species of human CRK cDNA encode proteins with distinct biological activities publication-title: Mol. Cell. Biol contributor: fullname: Shibuya – volume: 22 start-page: 7950 year: 2003 end-page: 7957 ident: bib8 article-title: Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas publication-title: Oncogene contributor: fullname: Beer – volume: 9 start-page: 676 year: 2012 end-page: 682 ident: bib59 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods contributor: fullname: Cardona – volume: 23 start-page: 3984 year: 2004 end-page: 3994 ident: bib35 article-title: PVR plays a critical role via JNK activation in thorax closure during publication-title: EMBO J contributor: fullname: Hanafusa – volume: 76 start-page: 163 year: 2015 end-page: 169 ident: bib55 article-title: CrkL meditates CCL20/CCR6-induced EMT in gastric cancer publication-title: Cytokine contributor: fullname: Li – volume: 9 start-page: 676 year: 2012 ident: 10.1074/jbc.M116.764613_bib59 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods doi: 10.1038/nmeth.2019 contributor: fullname: Schindelin – volume: 3 start-page: 334 year: 2012 ident: 10.1074/jbc.M116.764613_bib20 article-title: Roles for crk in cancer metastasis and invasion publication-title: Genes Cancer doi: 10.1177/1947601912458687 contributor: fullname: Tsuda – volume: 24 start-page: 2451 year: 2010 ident: 10.1074/jbc.M116.764613_bib49 article-title: Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L publication-title: Genes Dev doi: 10.1101/gad.1977710 contributor: fullname: Hallock – volume: 122 start-page: 4228 year: 2009 ident: 10.1074/jbc.M116.764613_bib44 article-title: Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals publication-title: J. Cell Sci doi: 10.1242/jcs.054627 contributor: fullname: Antoku – volume: 161 start-page: 67 year: 2003 ident: 10.1074/jbc.M116.764613_bib47 article-title: Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53 publication-title: J. Cell Biol doi: 10.1083/jcb.200208140 contributor: fullname: Lohez – volume: 32 start-page: 47 year: 2015 ident: 10.1074/jbc.M116.764613_bib54 article-title: Crk-like adapter protein regulates CCL19/CCR7-mediated epithelial-to-mesenchymal transition via ERK signaling pathway in epithelial ovarian carcinomas publication-title: Med. Oncol doi: 10.1007/s12032-015-0494-1 contributor: fullname: Cheng – volume: 7 start-page: 618 year: 2010 ident: 10.1074/jbc.M116.764613_bib23 article-title: Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.08.012 contributor: fullname: Warren – volume: 9 start-page: 3179 year: 1998 ident: 10.1074/jbc.M116.764613_bib46 article-title: Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension publication-title: Mol. Biol. Cell doi: 10.1091/mbc.9.11.3179 contributor: fullname: Huang – volume: 76 start-page: 163 year: 2015 ident: 10.1074/jbc.M116.764613_bib55 article-title: CrkL meditates CCL20/CCR6-induced EMT in gastric cancer publication-title: Cytokine doi: 10.1016/j.cyto.2015.05.009 contributor: fullname: Han – volume: 50 start-page: 506 year: 2011 ident: 10.1074/jbc.M116.764613_bib6 article-title: Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma publication-title: Mol. Carcinog doi: 10.1002/mc.20745 contributor: fullname: Wang – volume: 98 start-page: 11450 year: 2001 ident: 10.1074/jbc.M116.764613_bib29 article-title: Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo publication-title: Proc. Natl. Acad. Sci. U.S.A doi: 10.1073/pnas.201415498 contributor: fullname: Pfeifer – volume: 63 start-page: 2335 year: 2003 ident: 10.1074/jbc.M116.764613_bib13 article-title: CrkI adapter protein modulates cell migration and invasion in glioblastoma publication-title: Cancer Res contributor: fullname: Takino – volume: 55 start-page: 97 year: 2016 ident: 10.1074/jbc.M116.764613_bib22 article-title: Crk and CrkL are required for cell transformation by v-fos and v-ras publication-title: Mol Carcinog doi: 10.1002/mc.22262 contributor: fullname: Koptyra – volume: 12 start-page: 347 year: 2012 ident: 10.1074/jbc.M116.764613_bib24 article-title: mRNA as a versatile tool for exogenous protein expression publication-title: Curr. Gene Ther doi: 10.2174/156652312802762536 contributor: fullname: Kuhn – volume: 22 start-page: 7950 year: 2003 ident: 10.1074/jbc.M116.764613_bib8 article-title: Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas publication-title: Oncogene doi: 10.1038/sj.onc.1206529 contributor: fullname: Miller – volume: 106 start-page: 709 year: 2015 ident: 10.1074/jbc.M116.764613_bib56 article-title: Adaptor protein CRK induces epithelial-mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop publication-title: Cancer Sci doi: 10.1111/cas.12662 contributor: fullname: Matsumoto – volume: 418 start-page: 104 year: 2012 ident: 10.1074/jbc.M116.764613_bib17 article-title: CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/j.bbrc.2011.12.142 contributor: fullname: Yanagi – volume: 105 start-page: 1172 year: 2008 ident: 10.1074/jbc.M116.764613_bib42 article-title: Mitogenic roles of Gab1 and Grb10 as direct cellular partners in the regulation of MAP kinase signaling publication-title: J. Cell. Biochem doi: 10.1002/jcb.21829 contributor: fullname: Deng – volume: 275 start-page: 255 year: 2002 ident: 10.1074/jbc.M116.764613_bib45 article-title: A discrete cell cycle checkpoint in late G1 that is cytoskeleton-dependent and MAP kinase (Erk)-independent publication-title: Exp. Cell Res doi: 10.1006/excr.2002.5504 contributor: fullname: Huang – volume: 271 start-page: 23255 year: 1996 ident: 10.1074/jbc.M116.764613_bib4 article-title: The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene publication-title: J. Biol. Chem doi: 10.1074/jbc.271.38.23255 contributor: fullname: Senechal – volume: 3 start-page: 341 year: 2012 ident: 10.1074/jbc.M116.764613_bib30 article-title: Models of crk adaptor proteins in cancer publication-title: Genes Cancer doi: 10.1177/1947601912459951 contributor: fullname: Bell – volume: 36 start-page: 915 year: 2015 ident: 10.1074/jbc.M116.764613_bib52 article-title: Crk-like adapter protein is required for TGF-β-induced AKT and ERK-signaling pathway in epithelial ovarian carcinomas publication-title: Tumour Biol doi: 10.1007/s13277-014-2724-0 contributor: fullname: Cheng – volume: 22 start-page: 4929 year: 2002 ident: 10.1074/jbc.M116.764613_bib40 article-title: The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH2-terminal kinase publication-title: Mol. Cell. Biol doi: 10.1128/MCB.22.13.4929-4942.2002 contributor: fullname: Lei – volume: 125 start-page: 1019 year: 2015 ident: 10.1074/jbc.M116.764613_bib50 article-title: CRK proteins selectively regulate T cell migration into inflamed tissues publication-title: J. Clin. Invest doi: 10.1172/JCI77278 contributor: fullname: Huang – volume: 3 start-page: 183 year: 2005 ident: 10.1074/jbc.M116.764613_bib11 article-title: CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells publication-title: Mol. Cancer Res doi: 10.1158/1541-7786.MCR-04-0211 contributor: fullname: Rodrigues – volume: 180 start-page: 55 year: 2002 ident: 10.1074/jbc.M116.764613_bib7 article-title: Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers publication-title: Cancer Lett doi: 10.1016/S0304-3835(01)00763-7 contributor: fullname: Nishihara – volume: 275 start-page: 12667 year: 2000 ident: 10.1074/jbc.M116.764613_bib36 article-title: Crk activation of JNK via C3G and R-Ras publication-title: J. Biol. Chem doi: 10.1074/jbc.275.17.12667 contributor: fullname: Mochizuki – volume: 98 start-page: 9209 year: 2001 ident: 10.1074/jbc.M116.764613_bib28 article-title: Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells publication-title: Proc. Natl. Acad. Sci. U.S.A doi: 10.1073/pnas.161269798 contributor: fullname: Loonstra – volume: 29 start-page: 388 year: 2008 ident: 10.1074/jbc.M116.764613_bib31 article-title: A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling publication-title: Trends Immunol doi: 10.1016/j.it.2008.04.006 contributor: fullname: Isakov – volume: 115 start-page: 819 year: 2014 ident: 10.1074/jbc.M116.764613_bib2 article-title: Crk at the quarter century mark: perspectives in signaling and cancer publication-title: J. Cell. Biochem doi: 10.1002/jcb.24749 contributor: fullname: Kumar – volume: 273 start-page: 3408 year: 1998 ident: 10.1074/jbc.M116.764613_bib25 article-title: Cell density modulates protein-tyrosine phosphorylation publication-title: J. Biol. Chem doi: 10.1074/jbc.273.6.3408 contributor: fullname: Batt – volume: 16 start-page: 2634 year: 1997 ident: 10.1074/jbc.M116.764613_bib39 article-title: Activation of the JNK pathway is essential for transformation by the Met oncogene publication-title: EMBO J doi: 10.1093/emboj/16.10.2634 contributor: fullname: Rodrigues – volume: 303 start-page: 84 year: 2011 ident: 10.1074/jbc.M116.764613_bib5 article-title: Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma publication-title: Cancer Lett doi: 10.1016/j.canlet.2011.01.004 contributor: fullname: Yamada – volume: 41 start-page: 1372 year: 2003 ident: 10.1074/jbc.M116.764613_bib33 article-title: Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation publication-title: Hypertension doi: 10.1161/01.HYP.0000069698.11814.F4 contributor: fullname: Kodama – volume: 106 start-page: 3423 year: 2005 ident: 10.1074/jbc.M116.764613_bib34 article-title: Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways publication-title: Blood doi: 10.1182/blood-2005-04-1388 contributor: fullname: Salameh – volume: 7 start-page: 13 year: 2009 ident: 10.1074/jbc.M116.764613_bib32 article-title: Crk and CrkL adaptor proteins: networks for physiological and pathological signaling publication-title: Cell Commun. Signal doi: 10.1186/1478-811X-7-13 contributor: fullname: Birge – volume: 28 start-page: 13551 year: 2008 ident: 10.1074/jbc.M116.764613_bib51 article-title: Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway publication-title: J. Neurosci doi: 10.1523/JNEUROSCI.4323-08.2008 contributor: fullname: Park – volume: 33 start-page: 573 year: 2002 ident: 10.1074/jbc.M116.764613_bib53 article-title: Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice publication-title: Neuron doi: 10.1016/S0896-6273(02)00582-2 contributor: fullname: Magdaleno – volume: 13 start-page: 1449 year: 2002 ident: 10.1074/jbc.M116.764613_bib26 article-title: Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions publication-title: Mol. Biol. Cell doi: 10.1091/mbc.01-10-0477 contributor: fullname: Lamorte – volume: 52 start-page: 890 year: 2013 ident: 10.1074/jbc.M116.764613_bib9 article-title: Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer publication-title: Mol Carcinog doi: 10.1002/mc.21935 contributor: fullname: Wang – volume: 4 start-page: 499 year: 2006 ident: 10.1074/jbc.M116.764613_bib16 article-title: Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-05-0141 contributor: fullname: Watanabe – volume: 362 start-page: 976 year: 2007 ident: 10.1074/jbc.M116.764613_bib14 article-title: Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/j.bbrc.2007.08.106 contributor: fullname: Wang – volume: 23 start-page: 3984 year: 2004 ident: 10.1074/jbc.M116.764613_bib35 article-title: PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis publication-title: EMBO J doi: 10.1038/sj.emboj.7600417 contributor: fullname: Ishimaru – volume: 94 start-page: 2356 year: 1997 ident: 10.1074/jbc.M116.764613_bib37 article-title: Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G publication-title: Proc. Natl. Acad. Sci. U.S.A doi: 10.1073/pnas.94.6.2356 contributor: fullname: Tanaka – volume: 85 start-page: 1382 year: 2014 ident: 10.1074/jbc.M116.764613_bib48 article-title: Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis publication-title: Kidney Int doi: 10.1038/ki.2013.556 contributor: fullname: George – volume: 32 start-page: 5429 year: 2013 ident: 10.1074/jbc.M116.764613_bib18 article-title: Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth publication-title: Oncogene doi: 10.1038/onc.2012.590 contributor: fullname: Yeung – volume: 12 start-page: 3482 year: 1992 ident: 10.1074/jbc.M116.764613_bib3 article-title: Two species of human CRK cDNA encode proteins with distinct biological activities publication-title: Mol. Cell. Biol contributor: fullname: Matsuda – volume: 33 start-page: 5121 year: 2014 ident: 10.1074/jbc.M116.764613_bib21 article-title: Essential roles of Crk and CrkL in fibroblast structure and motility publication-title: Oncogene doi: 10.1038/onc.2013.453 contributor: fullname: Park – volume: 53 start-page: 907 year: 1988 ident: 10.1074/jbc.M116.764613_bib1 article-title: Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C publication-title: Cold Spring Harb. Symp. Quant. Biol doi: 10.1101/SQB.1988.053.01.104 contributor: fullname: Mayer – volume: 25 start-page: 3547 year: 2006 ident: 10.1074/jbc.M116.764613_bib15 article-title: Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS publication-title: Oncogene doi: 10.1038/sj.onc.1209398 contributor: fullname: Linghu – volume: 26 start-page: 6272 year: 2006 ident: 10.1074/jbc.M116.764613_bib58 article-title: Cardiovascular and craniofacial defects in Crk-null mice publication-title: Mol. Cell. Biol doi: 10.1128/MCB.00472-06 contributor: fullname: Park – volume: 678 start-page: 1 year: 2012 ident: 10.1074/jbc.M116.764613_bib43 article-title: Effect of celecoxib on proliferation, collagen expression, ERK1/2 and SMAD2/3 phosphorylation in NIH/3T3 fibroblasts publication-title: Eur. J. Pharmacol doi: 10.1016/j.ejphar.2011.12.018 contributor: fullname: Li – volume: 7 start-page: 27094 year: 2016 ident: 10.1074/jbc.M116.764613_bib57 article-title: Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer publication-title: Oncotarget doi: 10.18632/oncotarget.8314 contributor: fullname: Elmansuri – volume: 28 start-page: 391 year: 2011 ident: 10.1074/jbc.M116.764613_bib27 article-title: c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells publication-title: Clin. Exp. Metastasis doi: 10.1007/s10585-011-9378-8 contributor: fullname: Mortazavi – volume: 19 start-page: 5973 year: 2000 ident: 10.1074/jbc.M116.764613_bib38 article-title: A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein publication-title: Oncogene doi: 10.1038/sj.onc.1203977 contributor: fullname: Lamorte – volume: 206 start-page: 230 year: 2013 ident: 10.1074/jbc.M116.764613_bib12 article-title: CRKL promotes cell proliferation in gastric cancer and is negatively regulated by miR-126 publication-title: Chem. Biol. Interact doi: 10.1016/j.cbi.2013.09.003 contributor: fullname: Wang – volume: 80 start-page: 790 year: 2002 ident: 10.1074/jbc.M116.764613_bib41 article-title: Growth factor stimulated cell proliferation is accompanied by an elevated labile intracellular pool of zinc in 3T3 cells publication-title: Can. J. Physiol. Pharmacol doi: 10.1139/y02-101 contributor: fullname: Paski – volume: 14 start-page: R74 year: 2012 ident: 10.1074/jbc.M116.764613_bib10 article-title: Crk adaptor proteins act as key signaling integrators for breast tumorigenesis publication-title: Breast Cancer Res doi: 10.1186/bcr3183 contributor: fullname: Fathers – volume: 1 start-page: 1132 year: 2010 ident: 10.1074/jbc.M116.764613_bib19 article-title: Emerging roles for crk in human cancer publication-title: Genes Cancer doi: 10.1177/1947601910397188 contributor: fullname: Sriram |
SSID | ssj0000491 |
Score | 2.3568726 |
Snippet | CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk. Elevated levels of Crk and CrkL have been... CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk Elevated levels of Crk and CrkL have been observed... CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk . Elevated levels of Crk and CrkL have been... |
SourceID | pubmedcentral crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 26273 |
SubjectTerms | adaptor protein Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals apoptosis Apoptosis - drug effects Apoptosis - genetics Cell Biology cell cycle cell growth Cytoplasm - genetics Cytoplasm - metabolism fibroblast Fibroblast Growth Factor 2 - pharmacology Fibroblasts - cytology Fibroblasts - metabolism G1 Phase - drug effects G1 Phase - physiology Gene Knockdown Techniques growth factor Humans Mice Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-crk - genetics Proto-Oncogene Proteins c-crk - metabolism S Phase - drug effects S Phase - physiology serum |
Title | Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL) |
URI | https://dx.doi.org/10.1074/jbc.M116.764613 https://www.ncbi.nlm.nih.gov/pubmed/27807028 https://pubmed.ncbi.nlm.nih.gov/PMC5159491 |
Volume | 291 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT4MwFH5xu-jF-Nv5Kz0Yowc2gdIfR0OcRp1Ro4k3QqFkU8eWiQf_e18LNe5gTLwBpYS8Nv2-B1_fB3AodehHmklPByLyaJBpT-WpNm7uiuXYludmg_Pgll0-0avn6HkBIrcXxor2MzXqlm_jbjkaWm3ldJz1nE6sdzeIDQZT6fda0OJh6FJ0t_zSxibPaA-CSLh6Ppz2XlTWHfg-63JGEcZMIWAucM4bK_Y_UGleMfkDgvorsNxwR3JWv-MqLOhyDdbPSsybx5_kiFg1p_1MvgaLsXNyW4dBH3PiiUKeXJELTLurIXnQRgGs30n86J_imTWkn8zIpCDXoxKRjRzHs9cTkpY5wQPvbfRaX7o52YCn_vljfOk1NgpeRoWsvIirNC8YPVXI_bhIJXK6EPMkZTbNZkgBCik415iWKkmDAgE-ZdIYJUQ6T2mRhZvQLiel3gYitFCFDFLkSaYlE7lvNFd-qDUTmhUdOHZhTKZ1tYzE_uXmNMHgJyb4SR38DgQuzEkD9jWIJ7iW_95pqx6H76e7AewAnxuh7xtM-ez5FpxVtox2M4t2_t1zF5aQPlkbI5_tQbuafeh9pCiVOoDW9b04sBPzC5PZ4-0 |
link.rule.ids | 230,315,733,786,790,891,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT5xAFH6xerCXWrXVta2dQ9PoAVbYYX4cDem61sU0zdp4I8wwxHVd1mzx0P71fTMwptukaeoNeEAg38D7HnzzPoAP0gyixDAZmFgkAY21CVRZGOvmrliJsbK0E5yzSza6op-vk-s1SPxcGCfa12oa1nfzsJ7eOG3l_Vz3vU6s_yVLbQ6mMuo_gw18XuPEF-n-BUw7ozyrPogT4Tv6cNq_VTrMooiFnFFMZLYVMBc46q0Z-z_y0qpm8rckNNyCb_7yW-3JLHxoVKh__tHZ8b_v7yW86GgpOW3D27Bm6h3YPa2xJJ__IB-JE4q6L_A7sJl6k7hdyIZYbi8UUvCGnGFF39yQr8aKi813kk6iE1xzXveLJVlU5GJaY9IkR-lydkyKuiS4ENxNZ-2m8fEruBp-mqSjoHNoCDQVsgkSroqyYvREIa3kopBIFwdYgik7H1cju6ik4NxgxaskjSvkDgWT1oMhMWVBKz14Dev1ojb7QIQRqpJxgRTMRrQoIyvnigbGMGFY1YMjj09-3zbiyN0PdE5zRDW3qOYtqj2IPX55xyNafpBjmvj7QXstwI9n9yOjB3wF-scdbGfu1QgC6jp0dwAePPnI97A5mmTjfHx-efEGniNLc25JEXsL683ywbxDJtSoQzfufwHFDgT_ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1dT9RAFL1RTNQXP0B0VXQejIGHtrQ7nY9HUllRWEIMJMSXpvPRsC7b3azlQX49d6YdwpoYE97azkyTyZn2ntueuQfgk7TDNLdMRjYTeUQzbSNlKuvc3BUz2GaM2-A8PmYHZ_T7eX5-x-rLi_a1msTN5SxuJhdeW7mY6SToxJKTceFiMJVpsjB18hAe4TOb8ZCoh5cw7c3ynAIhy0Wo6sNp8kvpeJymLOaMYjBz5YC5wJXvDNn_E5tWdZN3AtHoOfwMU-j0J9P4qlWxvv6ruuO95vgCnvX0lOx1XV7CA9usw8Zeg6n57A_5TLxg1H-JX4cnRTCL24DxCNPuuUIq3pKvmNm3F-SHdSJj-5sUp-kunnnP-_mSzGtyOGkweJLtYjndIVVjCB5El5Npd-lo5xWcjfZPi4Ood2qINBWyjXKuKlMzuquQXnJRSaSNQ0zFlNuXq5Fl1FJwbjHzVZJmNXKIiknnxZBbU9FaDzdhrZk39g0QYYWqZVYhFXMtWpjUybrSobVMWFYPYDtgVC66ghyl_5HOaYnIlg7ZskN2AFnAsOz5RMcTSgwX_x70ugP59u5hdQyAr8B_28FV6F5tQVB9pe4exLf3HvkRHp98GZVH344P38FTJGveNCll72GtXV7ZLSRErfrgl_4NFuQHfw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fibroblast+Growth+Requires+CT10+Regulator+of+Kinase+%28Crk%29+and+Crk-like+%28CrkL%29&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Park%2C+Taeju&rft.au=Koptyra%2C+Mateusz&rft.au=Curran%2C+Tom&rft.date=2016-12-16&rft.eissn=1083-351X&rft.volume=291&rft.issue=51&rft.spage=26273&rft_id=info:doi/10.1074%2Fjbc.M116.764613&rft_id=info%3Apmid%2F27807028&rft.externalDocID=27807028 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon |