Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients

• Published in: Cytotherapy (Oxford, England) Vol. 11; no. 1; pp. 26 - 34
• Main Authors: Martinez, Hector R, Gonzalez-Garza, Maria T, Moreno-Cuevas, Jorge E, Caro, Enrique, Gutierrez-Jimenez, Eugenio, Segura, Jose J
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.01.2009; Informa UK Ltd
• Subjects: AC133 Antigen; Adult; Advanced Basic Science; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - mortality; Amyotrophic Lateral Sclerosis - surgery; Antigens, CD - metabolism; autologous transplant; CD133; Female; Filgrastim; Glycoproteins - metabolism; Granulocyte Colony-Stimulating Factor - administration & dosage; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - physiology; Humans; Male; Middle Aged; Motor Cortex - surgery; neurodegenerative disorders; Other; Peptides - metabolism; Recombinant Proteins; stem cells; Transplantation, Autologous - methods; stem cells; Amyotrophic lateral sclerosis; neurodegenerative disorders; autologous transplant; CD133

Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Methods...