Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients
Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Methods...
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Published in | Cytotherapy (Oxford, England) Vol. 11; no. 1; pp. 26 - 34 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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England
Elsevier Inc
01.01.2009
Informa UK Ltd |
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Abstract | Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Methods Five men and five women (aged 38–62 years) with confirmed ALS were included in this study. Our institutional ethics and research committees approved the protocol. After informed consent was obtained, patients underwent Hidrogen-Magnetic Resonance Imaging (H-MRI) spectroscopy and were given scores according to an ALS functional rating scale, Medical Research Council power muscle scale and daily living activities. Bone marrow was stimulated with 300 µg filgrastim subcutaneously daily for 3 days. Peripheral blood mononuclear cells were obtained after admission by leukapheresis. The cell suspension was conjugated with anti-human CD133 superparamagnetic microbeads, and linked cells were isolated in a magnetic field. The isolated cells (2.5–7.5 × 105 ) were resuspended in 300 µL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. Ten patients with confirmed ALS without transplantation were used as a control group. Patients were followed up for a period of 1 year. Results The autologous transplantation of CD133+ stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. The survival of treated patients was statistically higher ( P = 0.01) than untreated control patients. Conclusions Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. |
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AbstractList | Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Methods Five men and five women (aged 38–62 years) with confirmed ALS were included in this study. Our institutional ethics and research committees approved the protocol. After informed consent was obtained, patients underwent Hidrogen-Magnetic Resonance Imaging (H-MRI) spectroscopy and were given scores according to an ALS functional rating scale, Medical Research Council power muscle scale and daily living activities. Bone marrow was stimulated with 300 µg filgrastim subcutaneously daily for 3 days. Peripheral blood mononuclear cells were obtained after admission by leukapheresis. The cell suspension was conjugated with anti-human CD133 superparamagnetic microbeads, and linked cells were isolated in a magnetic field. The isolated cells (2.5–7.5 × 105 ) were resuspended in 300 µL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. Ten patients with confirmed ALS without transplantation were used as a control group. Patients were followed up for a period of 1 year. Results The autologous transplantation of CD133+ stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. The survival of treated patients was statistically higher ( P = 0.01) than untreated control patients. Conclusions Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Five men and five women (aged 38–62 years) with confirmed ALS were included in this study. Our institutional ethics and research committees approved the protocol. After informed consent was obtained, patients underwent Hidrogen-Magnetic Resonance Imaging (H-MRI) spectroscopy and were given scores according to an ALS functional rating scale, Medical Research Council power muscle scale and daily living activities. Bone marrow was stimulated with 300µg filgrastim subcutaneously daily for 3 days. Peripheral blood mononuclear cells were obtained after admission by leukapheresis. The cell suspension was conjugated with anti-human CD133 superparamagnetic microbeads, and linked cells were isolated in a magnetic field. The isolated cells (2.5–7.5×105) were resuspended in 300µL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. Ten patients with confirmed ALS without transplantation were used as a control group. Patients were followed up for a period of 1 year. The autologous transplantation of CD133+ stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. The survival of treated patients was statistically higher (P=0.01) than untreated control patients. Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Methods Five men and five women (aged 38-62 years) with confirmed ALS were included in this study. Our institutional ethics and research committees approved the protocol. After informed consent was obtained, patients underwent Hidrogen-Magnetic Resonance Imaging (H-MRI) spectroscopy and were given scores according to an ALS functional rating scale, Medical Research Council power muscle scale and daily living activities. Bone marrow was stimulated with 300 µg filgrastim subcutaneously daily for 3 days. Peripheral blood mononuclear cells were obtained after admission by leukapheresis. The cell suspension was conjugated with anti-human CD133 superparamagnetic microbeads, and linked cells were isolated in a magnetic field. The isolated cells (2.5-7.5X105) were resuspended in 300 µL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. Ten patients with confirmed ALS without transplantation were used as a control group. Patients were followed up for a period of 1 year. Results The autologous transplantation of CD133+ stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. The survival of treated patients was statistically higher (P=0.01) than untreated control patients. Conclusions Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. BACKGROUND AIMSAmyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133(+) stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases.METHODSFive men and five women (aged 38-62 years) with confirmed ALS were included in this study. Our institutional ethics and research committees approved the protocol. After informed consent was obtained, patients underwent Hidrogen-Magnetic Resonance Imaging (H-MRI) spectroscopy and were given scores according to an ALS functional rating scale, Medical Research Council power muscle scale and daily living activities. Bone marrow was stimulated with 300 microg filgrastim subcutaneously daily for 3 days. Peripheral blood mononuclear cells were obtained after admission by leukapheresis. The cell suspension was conjugated with anti-human CD133 superparamagnetic microbeads, and linked cells were isolated in a magnetic field. The isolated cells (2.5-7.5x10(5)) were resuspended in 300 microL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. Ten patients with confirmed ALS without transplantation were used as a control group. Patients were followed up for a period of 1 year.RESULTSThe autologous transplantation of CD133(+) stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. The survival of treated patients was statistically higher (P=0.01) than untreated control patients.CONCLUSIONSStem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Methods Five men and five women (aged 38-62 years) with confirmed ALS were included in this study. Our institutional ethics and research committees approved the protocol. After informed consent was obtained, patients underwent Hidrogen-Magnetic Resonance Imaging (H-MRI) spectroscopy and were given scores according to an ALS functional rating scale, Medical Research Council power muscle scale and daily living activities. Bone marrow was stimulated with 300 µg filgrastim subcutaneously daily for 3 days. Peripheral blood mononuclear cells were obtained after admission by leukapheresis. The cell suspension was conjugated with anti-human CD133 superparamagnetic microbeads, and linked cells were isolated in a magnetic field. The isolated cells (2.5-7.5×105) were resuspended in 300 µL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. Ten patients with confirmed ALS without transplantation were used as a control group. Patients were followed up for a period of 1 year. Results The autologous transplantation of CD133+ stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. The survival of treated patients was statistically higher (P=0.01) than untreated control patients. Conclusions Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133(+) stem cells are known to have the capacity to differentiate into neural lineages. Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. Five men and five women (aged 38-62 years) with confirmed ALS were included in this study. Our institutional ethics and research committees approved the protocol. After informed consent was obtained, patients underwent Hidrogen-Magnetic Resonance Imaging (H-MRI) spectroscopy and were given scores according to an ALS functional rating scale, Medical Research Council power muscle scale and daily living activities. Bone marrow was stimulated with 300 microg filgrastim subcutaneously daily for 3 days. Peripheral blood mononuclear cells were obtained after admission by leukapheresis. The cell suspension was conjugated with anti-human CD133 superparamagnetic microbeads, and linked cells were isolated in a magnetic field. The isolated cells (2.5-7.5x10(5)) were resuspended in 300 microL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. Ten patients with confirmed ALS without transplantation were used as a control group. Patients were followed up for a period of 1 year. The autologous transplantation of CD133(+) stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. The survival of treated patients was statistically higher (P=0.01) than untreated control patients. Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. |
Author | Martinez, Hector R. Segura, Jose J. Gonzalez-Garza, Maria T. Gutierrez-Jimenez, Eugenio Moreno-Cuevas, Jorge E. Caro, Enrique |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19191058$$D View this record in MEDLINE/PubMed |
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Keywords | stem cells Amyotrophic lateral sclerosis neurodegenerative disorders autologous transplant CD133 |
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article-title: Stem cell therapy for neurodegenerative diseases: the issue of transdifferentiation publication-title: Stem Cells Dev doi: 10.1089/154732804773099326 contributor: fullname: Cova |
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Snippet | Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity... Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity to differentiate... Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133+ stem cells are known to have the capacity... Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133(+) stem cells are known to have the capacity to... BACKGROUND AIMSAmyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133(+) stem cells are known to have the capacity... |
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SubjectTerms | AC133 Antigen Adult Advanced Basic Science Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - mortality Amyotrophic Lateral Sclerosis - surgery Antigens, CD - metabolism autologous transplant CD133 Female Filgrastim Glycoproteins - metabolism Granulocyte Colony-Stimulating Factor - administration & dosage Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Humans Male Middle Aged Motor Cortex - surgery neurodegenerative disorders Other Peptides - metabolism Recombinant Proteins stem cells Transplantation, Autologous - methods |
Title | Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients |
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