Additive partially linear model for pooled biomonitoring data

Human biomonitoring involves monitoring human health by measuring the accumulation of harmful chemicals, typically in specimens like blood samples. The high cost of chemical analysis has led researchers to adopt a cost-effective approach. This approach physically combines specimens and subsequently...

Full description

Saved in:
Bibliographic Details
Published inComputational statistics & data analysis Vol. 190; p. 107862
Main Authors Mou, Xichen, Wang, Dewei
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2024
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Human biomonitoring involves monitoring human health by measuring the accumulation of harmful chemicals, typically in specimens like blood samples. The high cost of chemical analysis has led researchers to adopt a cost-effective approach. This approach physically combines specimens and subsequently analyzes the concentration of toxic substances within the merged pools. Consequently, there arises a need for innovative regression techniques to effectively interpret these aggregated measurements. To address this need, a new regression framework is proposed by extending the additive partially linear model (APLM) to accommodate the pooling context. The APLM is well-known for its versatility in capturing the complex association between outcomes and covariates, which is particularly valuable in assessing the complex interplay between chemical bioaccumulation and potential risk factors. Consistent estimators of the APLM are obtained through an iterative process that disaggregates information from the pooled observations. The performance is evaluated through simulations and an environmental health study focused on brominated flame retardants using data from the National Health and Nutrition Examination Survey.
AbstractList Human biomonitoring involves monitoring human health by measuring the accumulation of harmful chemicals, typically in specimens like blood samples. The high cost of chemical analysis has led researchers to adopt a cost-effective approach. This approach physically combines specimens and subsequently analyzes the concentration of toxic substances within the merged pools. Consequently, there arises a need for innovative regression techniques to effectively interpret these aggregated measurements. To address this need, a new regression framework is proposed by extending the additive partially linear model (APLM) to accommodate the pooling context. The APLM is well-known for its versatility in capturing the complex association between outcomes and covariates, which is particularly valuable in assessing the complex interplay between chemical bioaccumulation and potential risk factors. Consistent estimators of the APLM are obtained through an iterative process that disaggregates information from the pooled observations. The performance is evaluated through simulations and an environmental health study focused on brominated flame retardants using data from the National Health and Nutrition Examination Survey.
Human biomonitoring involves monitoring human health by measuring the accumulation of harmful chemicals, typically in specimens like blood samples. The high cost of chemical analysis has led researchers to adopt a cost-effective approach. This approach physically combines specimens and subsequently analyzes the concentration of toxic substances within the merged pools. Consequently, there arises a need for innovative regression techniques to effectively interpret these aggregated measurements. To address this need, a new regression framework is proposed by extending the additive partially linear model (APLM) to accommodate the pooling context. The APLM is well-known for its versatility in capturing the complex association between outcomes and covariates, which is particularly valuable in assessing the complex interplay between chemical bioaccumulation and potential risk factors. Consistent estimators of the APLM are obtained through an iterative process that disaggregates information from the pooled observations. The performance is evaluated through simulations and an environmental health study focused on brominated flame retardants using data from the National Health and Nutrition Examination Survey.Human biomonitoring involves monitoring human health by measuring the accumulation of harmful chemicals, typically in specimens like blood samples. The high cost of chemical analysis has led researchers to adopt a cost-effective approach. This approach physically combines specimens and subsequently analyzes the concentration of toxic substances within the merged pools. Consequently, there arises a need for innovative regression techniques to effectively interpret these aggregated measurements. To address this need, a new regression framework is proposed by extending the additive partially linear model (APLM) to accommodate the pooling context. The APLM is well-known for its versatility in capturing the complex association between outcomes and covariates, which is particularly valuable in assessing the complex interplay between chemical bioaccumulation and potential risk factors. Consistent estimators of the APLM are obtained through an iterative process that disaggregates information from the pooled observations. The performance is evaluated through simulations and an environmental health study focused on brominated flame retardants using data from the National Health and Nutrition Examination Survey.
ArticleNumber 107862
Author Mou, Xichen
Wang, Dewei
AuthorAffiliation a Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, U.S.A
b Department of Statistics, University of South Carolina, Columbia, SC 29208, U.S.A
AuthorAffiliation_xml – name: b Department of Statistics, University of South Carolina, Columbia, SC 29208, U.S.A
– name: a Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, U.S.A
Author_xml – sequence: 1
  givenname: Xichen
  orcidid: 0000-0002-1326-7877
  surname: Mou
  fullname: Mou, Xichen
  email: xmou@memphis.edu
  organization: Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA
– sequence: 2
  givenname: Dewei
  surname: Wang
  fullname: Wang, Dewei
  organization: Department of Statistics, University of South Carolina, Columbia, SC 29208, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38187953$$D View this record in MEDLINE/PubMed
BookMark eNqFkV1rFDEYhUOptNvqH_BC5tKbWfM1-QBFSrFVKHij1yGTvFOzZCZrkl3ovzfLtqJe1BAIvHnO4fCeC3S6pAUQek3wmmAi3m3Wrni7ppiyNpBK0BO0IkrSXrKBnqJVg2SvuWTn6KKUDcaYcqnO0DlTDdMDW6EPV96HGvbQbW2uwcb40MWwgM3dnDzEbkq526YUwXdjSHNaQk05LPedt9W-RC8mGwu8enwv0febT9-uP_d3X2-_XF_d9Y4rXftBisFhJkYLeNJ69NYrMVilFdF-klxMgkpohzhOPJPDyCw4yUfMCWZyZJfo49F3uxtn8A6Wmm002xxmmx9MssH8_bOEH-Y-7U1bi9AYy-bw9tEhp587KNXMoTiI0S6QdsUwMrQruBT_RakmRHFGuG7omz9z_Q70tN8GqCPgciolw2RcqLaGdIgZYstnDlWajTlUaQ5VmmOVTUr_kT65Pyt6fxRBa2MfIJviAiwOfMjgqvEpPCf_BUMNt5Q
CitedBy_id crossref_primary_10_3390_sym17030394
Cites_doi 10.1097/EE9.0000000000000032
10.1002/sim.3823
10.1021/es503727b
10.1016/j.envint.2013.03.003
10.1214/aoms/1177731363
10.1016/j.chemosphere.2013.12.064
10.1021/es303471d
10.1128/JCM.00650-11
10.1016/j.bihy.2008.06.003
10.1007/s11356-016-7571-7
10.1002/sim.4304
10.1016/j.toxlet.2013.11.011
10.1097/OLQ.0b013e318231cd4a
10.1128/JCM.05631-11
10.1111/ina.12221
10.1186/1475-2891-5-13
10.1002/sim.5341
10.1021/es060301u
10.1021/es803156p
10.1214/11-AOS952
10.1111/j.2517-6161.1993.tb01939.x
10.1016/j.marpolbul.2009.09.006
10.1080/02664763.2011.567254
10.1111/biom.12134
10.1016/j.chemosphere.2004.08.095
10.1007/s13253-010-0032-8
10.1016/0304-4076(93)90114-K
10.1086/303097
10.1080/10485252.2018.1483501
10.1080/01621459.1987.10478440
10.1080/10485252.2020.1834104
10.1038/s41598-020-74853-9
10.1002/sim.7291
ContentType Journal Article
Copyright 2023
Copyright_xml – notice: 2023
DBID AAYXX
CITATION
NPM
7X8
7S9
L.6
5PM
DOI 10.1016/j.csda.2023.107862
DatabaseName CrossRef
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList AGRICOLA


PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Mathematics
EISSN 1872-7352
ExternalDocumentID PMC10769007
38187953
10_1016_j_csda_2023_107862
S0167947323001731
Genre Journal Article
GrantInformation_xml – fundername: NIAID NIH HHS
  grantid: R03 AI135614
GroupedDBID --K
--M
-~X
.~1
0R~
1B1
1OL
1RT
1~.
1~5
29F
4.4
457
4G.
5GY
5VS
7-5
71M
8P~
9JN
9JO
AAAKF
AAAKG
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARIN
AAXUO
AAYFN
ABAOU
ABBOA
ABFNM
ABMAC
ABTAH
ABUCO
ABXDB
ABYKQ
ACAZW
ACDAQ
ACGFS
ACNNM
ACRLP
ACZNC
ADBBV
ADEZE
ADGUI
ADJOM
ADMUD
ADTZH
AEBSH
AECPX
AEKER
AENEX
AFKWA
AFTJW
AGHFR
AGUBO
AGYEJ
AHHHB
AHJVU
AHZHX
AI.
AIALX
AIEXJ
AIGVJ
AIKHN
AITUG
AJBFU
AJOXV
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AOUOD
APLSM
ARUGR
ASPBG
AVWKF
AXJTR
AZFZN
BJAXD
BKOJK
BLXMC
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
GBOLZ
HAMUX
HLZ
HMJ
HVGLF
HZ~
H~9
IHE
J1W
JJJVA
KOM
LG9
LY1
M26
M41
MHUIS
MO0
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
RNS
ROL
RPZ
SBC
SDF
SDG
SDS
SES
SEW
SME
SPC
SPCBC
SSB
SSD
SST
SSV
SSW
SSZ
T5K
VH1
VOH
WUQ
XPP
ZMT
ZY4
~02
~G-
AAHBH
AATTM
AAXKI
AAYWO
AAYXX
ABJNI
ABWVN
ACRPL
ACVFH
ADCNI
ADNMO
ADXHL
AEIPS
AEUPX
AFJKZ
AFPUW
AFXIZ
AGCQF
AGQPQ
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
BNPGV
CITATION
SSH
EFKBS
NPM
7X8
7S9
L.6
5PM
ID FETCH-LOGICAL-c489t-5765c036bae0f99bdad865a89819df746f627eeee1c41d375b3aec74b041037b3
IEDL.DBID .~1
ISSN 0167-9473
IngestDate Thu Aug 21 18:39:01 EDT 2025
Mon Jul 21 10:37:15 EDT 2025
Fri Jul 11 15:40:18 EDT 2025
Mon Jul 21 06:06:51 EDT 2025
Tue Jul 01 02:24:39 EDT 2025
Thu Apr 24 23:02:11 EDT 2025
Fri Feb 23 02:33:38 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Biomarkers
Additive partially linear model
NHANES
Pooled biospecimens
Homogeneous pooling
Local linear fit
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c489t-5765c036bae0f99bdad865a89819df746f627eeee1c41d375b3aec74b041037b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-1326-7877
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/10769007
PMID 38187953
PQID 2911843149
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_10769007
proquest_miscellaneous_3153156476
proquest_miscellaneous_2911843149
pubmed_primary_38187953
crossref_citationtrail_10_1016_j_csda_2023_107862
crossref_primary_10_1016_j_csda_2023_107862
elsevier_sciencedirect_doi_10_1016_j_csda_2023_107862
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-02-01
PublicationDateYYYYMMDD 2024-02-01
PublicationDate_xml – month: 02
  year: 2024
  text: 2024-02-01
  day: 01
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Computational statistics & data analysis
PublicationTitleAlternate Comput Stat Data Anal
PublicationYear 2024
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Dorfman (br0010) 1943; 14
Fan, Gijbels (br0320) 1992
Heffernan, English, Toms, Calafat, Valentin-Blasini, Hobson, Broomhall, Ware, Jagals, Sly (br0110) 2016; 23
Sullivan, Patel, Hutchinson, Ethridge, Parker (br0020) 2011; 49
Kärrman, Mueller, Van Bavel, Harden, Toms, Lindström (br0100) 2006; 40
Fahey, Ourisson, Degnan (br0080) 2006; 5
Gastwirth (br0060) 2000; 67
Wang, Mou, Li, Huang (br0170) 2020; 32
Frouin, Lebeuf, Hammill, Masson, Fournier (br0290) 2010; 60
Kato, Calafat, Wong, Wanigatunga, Caudill, Needham (br0120) 2009; 43
Whitehead, Brown, Metayer, Park, Does, Petreas, Buffler, Rappaport (br0260) 2013; 57
Liu, McMahan, Gallagher (br0160) 2017; 36
Warner, Rauch, Coker, Harley, Kogut, Sjödin, Eskenazi (br0380) 2018; 2
Stapleton, Sharma, Getzinger, Ferguson, Gabriel, Webster, Blum (br0360) 2012; 46
Vexler, Tsai, Malinovsky (br0340) 2012; 31
Costa, de Laat, Tagliaferri, Pellacani (br0250) 2014; 230
Ichimura (br0180) 1993; 58
Zhang, Guo, Han, Zhu, Kilfoy, Zhu, Boyle, Zheng (br0300) 2008; 1
Mitchell, Lyles, Manatunga, Danaher, Perkins, Schisterman (br0150) 2014; 70
Van, Miller, Warshauer, Reisdorf, Jernigan, Humes, Shult (br0030) 2012; 50
Hastie, Tibshirani (br0200) 1987; 82
Sutton, Sedlak, Yee, Davis, Crane, Grace, Arsem (br0350) 2015; 49
Ma, Vexler, Schisterman, Tian (br0140) 2011; 38
Härdle, Liang, Gao (br0210) 2000
Hastie, Tibshirani (br0190) 1993; 55
Caudill (br0130) 2012; 31
Bates, Buckland, Garrett, Caudill, Ellis (br0090) 2005; 58
Delaigle, Hall (br0240) 2012; 40
Wang, Mou, Liu (br0230) 2021
Kim, Harden, Toms, Norman (br0370) 2014; 106
Kozlova, Chinthirla, Pérez, DiPatrizio, Argueta, Phillips, Stapleton, González, Krum, Carrillo (br0270) 2020; 10
Zhou, Jiang, Wang, Yang, Chen, Jiang (br0050) 2021; 375
Canbaz, Van Velzen, Hallner, Zwinderman, Wickman, Leonards, van Ree, Van Rijt (br0280) 2016; 26
Lin, Wang (br0220) 2018; 30
Schisterman, Vexler, Mumford, Perkins (br0330) 2010; 29
Opsomer, Ruppert (br0310) 1999; 8
Dhand, Johnson, Toribio (br0070) 2010; 15
Lewis, Lockary, Kobic (br0040) 2012; 39
Zhou (10.1016/j.csda.2023.107862_br0050) 2021; 375
Fahey (10.1016/j.csda.2023.107862_br0080) 2006; 5
Schisterman (10.1016/j.csda.2023.107862_br0330) 2010; 29
Liu (10.1016/j.csda.2023.107862_br0160) 2017; 36
Gastwirth (10.1016/j.csda.2023.107862_br0060) 2000; 67
Kärrman (10.1016/j.csda.2023.107862_br0100) 2006; 40
Lewis (10.1016/j.csda.2023.107862_br0040) 2012; 39
Bates (10.1016/j.csda.2023.107862_br0090) 2005; 58
Kim (10.1016/j.csda.2023.107862_br0370) 2014; 106
Vexler (10.1016/j.csda.2023.107862_br0340) 2012; 31
Stapleton (10.1016/j.csda.2023.107862_br0360) 2012; 46
Caudill (10.1016/j.csda.2023.107862_br0130) 2012; 31
Härdle (10.1016/j.csda.2023.107862_br0210) 2000
Dorfman (10.1016/j.csda.2023.107862_br0010) 1943; 14
Mitchell (10.1016/j.csda.2023.107862_br0150) 2014; 70
Kozlova (10.1016/j.csda.2023.107862_br0270) 2020; 10
Fan (10.1016/j.csda.2023.107862_br0320) 1992
Dhand (10.1016/j.csda.2023.107862_br0070) 2010; 15
Heffernan (10.1016/j.csda.2023.107862_br0110) 2016; 23
Kato (10.1016/j.csda.2023.107862_br0120) 2009; 43
Wang (10.1016/j.csda.2023.107862_br0170) 2020; 32
Opsomer (10.1016/j.csda.2023.107862_br0310) 1999; 8
Delaigle (10.1016/j.csda.2023.107862_br0240) 2012; 40
Ichimura (10.1016/j.csda.2023.107862_br0180) 1993; 58
Whitehead (10.1016/j.csda.2023.107862_br0260) 2013; 57
Van (10.1016/j.csda.2023.107862_br0030) 2012; 50
Canbaz (10.1016/j.csda.2023.107862_br0280) 2016; 26
Hastie (10.1016/j.csda.2023.107862_br0200) 1987; 82
Sullivan (10.1016/j.csda.2023.107862_br0020) 2011; 49
Warner (10.1016/j.csda.2023.107862_br0380) 2018; 2
Hastie (10.1016/j.csda.2023.107862_br0190) 1993; 55
Wang (10.1016/j.csda.2023.107862_br0230) 2021
Zhang (10.1016/j.csda.2023.107862_br0300) 2008; 1
Lin (10.1016/j.csda.2023.107862_br0220) 2018; 30
Costa (10.1016/j.csda.2023.107862_br0250) 2014; 230
Frouin (10.1016/j.csda.2023.107862_br0290) 2010; 60
Ma (10.1016/j.csda.2023.107862_br0140) 2011; 38
Sutton (10.1016/j.csda.2023.107862_br0350) 2015; 49
References_xml – volume: 23
  start-page: 23436
  year: 2016
  end-page: 23448
  ident: br0110
  article-title: Cross-sectional biomonitoring study of pesticide exposures in Queensland, Australia, using pooled urine samples
  publication-title: Environ. Sci. Pollut. Res.
– volume: 38
  start-page: 2739
  year: 2011
  end-page: 2750
  ident: br0140
  article-title: Cost-efficient designs based on linearly associated biomarkers
  publication-title: J. Appl. Stat.
– volume: 49
  start-page: 777
  year: 2015
  end-page: 784
  ident: br0350
  article-title: Declines in polybrominated diphenyl ether contamination of San Francisco bay following production phase-outs and bans
  publication-title: Environ. Sci. Technol.
– volume: 46
  start-page: 13432
  year: 2012
  end-page: 13439
  ident: br0360
  article-title: Novel and high volume use flame retardants in us couches reflective of the 2005 pentabde phase out
  publication-title: Environ. Sci. Technol.
– volume: 30
  start-page: 813
  year: 2018
  end-page: 833
  ident: br0220
  article-title: Single-index regression for pooled biomarker data
  publication-title: J. Nonparametr. Stat.
– volume: 36
  start-page: 2363
  year: 2017
  end-page: 2377
  ident: br0160
  article-title: A general framework for the regression analysis of pooled biomarker assessments
  publication-title: Stat. Med.
– volume: 40
  start-page: 3742
  year: 2006
  end-page: 3748
  ident: br0100
  article-title: Levels of 12 perfluorinated chemicals in pooled Australian serum, collected 2002–2003, in relation to age, gender, and region
  publication-title: Environ. Sci. Technol.
– volume: 58
  start-page: 71
  year: 1993
  end-page: 120
  ident: br0180
  article-title: Semiparametric least squares (sls) and weighted sls estimation of single-index models
  publication-title: J. Econom.
– volume: 31
  start-page: 2498
  year: 2012
  end-page: 2512
  ident: br0340
  article-title: Estimation and testing based on data subject to measurement errors: from parametric to non-parametric likelihood methods
  publication-title: Stat. Med.
– volume: 60
  start-page: 291
  year: 2010
  end-page: 298
  ident: br0290
  article-title: Effects of individual polybrominated diphenyl ether (pbde) congeners on harbour seal immune cells in vitro
  publication-title: Mar. Pollut. Bull.
– year: 2021
  ident: br0230
  article-title: Varying-coefficient regression analysis for pooled biomonitoring
  publication-title: Biometrics
– volume: 43
  start-page: 2641
  year: 2009
  end-page: 2647
  ident: br0120
  article-title: Polyfluoroalkyl compounds in pooled sera from children participating in the national health and nutrition examination survey 2001–2002
  publication-title: Environ. Sci. Technol.
– volume: 10
  start-page: 1
  year: 2020
  end-page: 17
  ident: br0270
  article-title: Maternal transfer of environmentally relevant polybrominated diphenyl ethers (pbdes) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring
  publication-title: Sci. Rep.
– volume: 29
  start-page: 597
  year: 2010
  end-page: 613
  ident: br0330
  article-title: Hybrid pooled–unpooled design for cost-efficient measurement of biomarkers
  publication-title: Stat. Med.
– volume: 67
  start-page: 1036
  year: 2000
  end-page: 1039
  ident: br0060
  article-title: The efficiency of pooling in the detection of rare mutations
  publication-title: Am. J. Hum. Genet.
– volume: 49
  start-page: 3667
  year: 2011
  end-page: 3668
  ident: br0020
  article-title: Evaluation of pooling strategies for acute hiv-1 infection screening using nucleic acid amplification testing
  publication-title: J. Clin. Microbiol.
– volume: 57
  start-page: 11
  year: 2013
  end-page: 24
  ident: br0260
  article-title: Polybrominated diphenyl ethers in residential dust: sources of variability
  publication-title: Environ. Int.
– volume: 26
  start-page: 403
  year: 2016
  end-page: 413
  ident: br0280
  article-title: Exposure to organophosphate and polybrominated diphenyl ether flame retardants via indoor dust and childhood asthma
  publication-title: Indoor Air
– volume: 55
  start-page: 757
  year: 1993
  end-page: 779
  ident: br0190
  article-title: Varying-coefficient models
  publication-title: J. R. Stat. Soc. Ser. B
– volume: 40
  start-page: 131
  year: 2012
  end-page: 158
  ident: br0240
  article-title: Nonparametric regression with homogeneous group testing data
  publication-title: Ann. Stat.
– volume: 2
  start-page: e032
  year: 2018
  ident: br0380
  article-title: Obesity in relation to serum persistent organic pollutant concentrations in chamacos women
  publication-title: Environ. Epidemiol.
– volume: 106
  start-page: 1
  year: 2014
  end-page: 19
  ident: br0370
  article-title: Health consequences of exposure to brominated flame retardants: a systematic review
  publication-title: Chemosphere
– volume: 5
  start-page: 13
  year: 2006
  ident: br0080
  article-title: Pathogen detection, testing, and control in fresh broccoli sprouts
  publication-title: Nutr. J.
– volume: 14
  start-page: 436
  year: 1943
  end-page: 440
  ident: br0010
  article-title: The detection of defective members of large populations
  publication-title: Ann. Math. Stat.
– volume: 31
  start-page: 3269
  year: 2012
  end-page: 3277
  ident: br0130
  article-title: Use of pooled samples from the national health and nutrition examination survey
  publication-title: Stat. Med.
– volume: 8
  start-page: 715
  year: 1999
  end-page: 732
  ident: br0310
  article-title: A root-n consistent backfitting estimator for semiparametric additive modeling
  publication-title: J. Comput. Graph. Stat.
– volume: 15
  start-page: 452
  year: 2010
  end-page: 473
  ident: br0070
  article-title: A Bayesian approach to estimate ojd prevalence from pooled fecal samples of variable pool size
  publication-title: J. Agric. Biol. Environ. Stat.
– volume: 32
  start-page: 814
  year: 2020
  end-page: 837
  ident: br0170
  article-title: Local polynomial regression for pooled response data
  publication-title: J. Nonparametr. Stat.
– volume: 58
  start-page: 943
  year: 2005
  end-page: 951
  ident: br0090
  article-title: Methodological aspects of a national population-based study of persistent organochlorine compounds in serum
  publication-title: Chemosphere
– volume: 50
  start-page: 891
  year: 2012
  end-page: 896
  ident: br0030
  article-title: Pooling nasopharyngeal/throat swab specimens to increase testing capacity for influenza viruses by pcr
  publication-title: J. Clin. Microbiol.
– volume: 230
  start-page: 282
  year: 2014
  end-page: 294
  ident: br0250
  article-title: A mechanistic view of polybrominated diphenyl ether (pbde) developmental neurotoxicity
  publication-title: Toxicol. Lett.
– volume: 82
  start-page: 371
  year: 1987
  end-page: 386
  ident: br0200
  article-title: Generalized additive models: some applications
  publication-title: J. Am. Stat. Assoc.
– year: 2000
  ident: br0210
  article-title: Partially Linear Models
– volume: 375
  year: 2021
  ident: br0050
  article-title: Use of contact tracing, isolation, and mass testing to control transmission of Covid-19 in China
  publication-title: BMJ
– volume: 39
  start-page: 46
  year: 2012
  end-page: 48
  ident: br0040
  article-title: Cost savings and increased efficiency using a stratified specimen pooling strategy for Chlamydia trachomatis and Neisseria gonorrhoeae
  publication-title: Sex. Transm. Dis.
– volume: 70
  start-page: 202
  year: 2014
  end-page: 211
  ident: br0150
  article-title: Regression for skewed biomarker outcomes subject to pooling
  publication-title: Biometrics
– volume: 1
  start-page: 195
  year: 2008
  end-page: 199
  ident: br0300
  article-title: Do polybrominated diphenyl ethers (pbde) increase the risk of thyroid cancer?
  publication-title: Biosci. Hypotheses
– start-page: 2008
  year: 1992
  end-page: 2036
  ident: br0320
  article-title: Variable bandwidth and local linear regression smoothers
  publication-title: Ann. Stat.
– volume: 2
  start-page: e032
  issue: 4
  year: 2018
  ident: 10.1016/j.csda.2023.107862_br0380
  article-title: Obesity in relation to serum persistent organic pollutant concentrations in chamacos women
  publication-title: Environ. Epidemiol.
  doi: 10.1097/EE9.0000000000000032
– volume: 29
  start-page: 597
  issue: 5
  year: 2010
  ident: 10.1016/j.csda.2023.107862_br0330
  article-title: Hybrid pooled–unpooled design for cost-efficient measurement of biomarkers
  publication-title: Stat. Med.
  doi: 10.1002/sim.3823
– volume: 49
  start-page: 777
  issue: 2
  year: 2015
  ident: 10.1016/j.csda.2023.107862_br0350
  article-title: Declines in polybrominated diphenyl ether contamination of San Francisco bay following production phase-outs and bans
  publication-title: Environ. Sci. Technol.
  doi: 10.1021/es503727b
– volume: 57
  start-page: 11
  year: 2013
  ident: 10.1016/j.csda.2023.107862_br0260
  article-title: Polybrominated diphenyl ethers in residential dust: sources of variability
  publication-title: Environ. Int.
  doi: 10.1016/j.envint.2013.03.003
– volume: 375
  year: 2021
  ident: 10.1016/j.csda.2023.107862_br0050
  article-title: Use of contact tracing, isolation, and mass testing to control transmission of Covid-19 in China
  publication-title: BMJ
– volume: 14
  start-page: 436
  issue: 4
  year: 1943
  ident: 10.1016/j.csda.2023.107862_br0010
  article-title: The detection of defective members of large populations
  publication-title: Ann. Math. Stat.
  doi: 10.1214/aoms/1177731363
– volume: 106
  start-page: 1
  year: 2014
  ident: 10.1016/j.csda.2023.107862_br0370
  article-title: Health consequences of exposure to brominated flame retardants: a systematic review
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2013.12.064
– volume: 46
  start-page: 13432
  issue: 24
  year: 2012
  ident: 10.1016/j.csda.2023.107862_br0360
  article-title: Novel and high volume use flame retardants in us couches reflective of the 2005 pentabde phase out
  publication-title: Environ. Sci. Technol.
  doi: 10.1021/es303471d
– volume: 49
  start-page: 3667
  issue: 10
  year: 2011
  ident: 10.1016/j.csda.2023.107862_br0020
  article-title: Evaluation of pooling strategies for acute hiv-1 infection screening using nucleic acid amplification testing
  publication-title: J. Clin. Microbiol.
  doi: 10.1128/JCM.00650-11
– volume: 1
  start-page: 195
  issue: 4
  year: 2008
  ident: 10.1016/j.csda.2023.107862_br0300
  article-title: Do polybrominated diphenyl ethers (pbde) increase the risk of thyroid cancer?
  publication-title: Biosci. Hypotheses
  doi: 10.1016/j.bihy.2008.06.003
– volume: 23
  start-page: 23436
  issue: 23
  year: 2016
  ident: 10.1016/j.csda.2023.107862_br0110
  article-title: Cross-sectional biomonitoring study of pesticide exposures in Queensland, Australia, using pooled urine samples
  publication-title: Environ. Sci. Pollut. Res.
  doi: 10.1007/s11356-016-7571-7
– volume: 31
  start-page: 2498
  issue: 22
  year: 2012
  ident: 10.1016/j.csda.2023.107862_br0340
  article-title: Estimation and testing based on data subject to measurement errors: from parametric to non-parametric likelihood methods
  publication-title: Stat. Med.
  doi: 10.1002/sim.4304
– volume: 230
  start-page: 282
  issue: 2
  year: 2014
  ident: 10.1016/j.csda.2023.107862_br0250
  article-title: A mechanistic view of polybrominated diphenyl ether (pbde) developmental neurotoxicity
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2013.11.011
– volume: 39
  start-page: 46
  issue: 1
  year: 2012
  ident: 10.1016/j.csda.2023.107862_br0040
  article-title: Cost savings and increased efficiency using a stratified specimen pooling strategy for Chlamydia trachomatis and Neisseria gonorrhoeae
  publication-title: Sex. Transm. Dis.
  doi: 10.1097/OLQ.0b013e318231cd4a
– volume: 50
  start-page: 891
  issue: 3
  year: 2012
  ident: 10.1016/j.csda.2023.107862_br0030
  article-title: Pooling nasopharyngeal/throat swab specimens to increase testing capacity for influenza viruses by pcr
  publication-title: J. Clin. Microbiol.
  doi: 10.1128/JCM.05631-11
– volume: 26
  start-page: 403
  issue: 3
  year: 2016
  ident: 10.1016/j.csda.2023.107862_br0280
  article-title: Exposure to organophosphate and polybrominated diphenyl ether flame retardants via indoor dust and childhood asthma
  publication-title: Indoor Air
  doi: 10.1111/ina.12221
– start-page: 2008
  year: 1992
  ident: 10.1016/j.csda.2023.107862_br0320
  article-title: Variable bandwidth and local linear regression smoothers
  publication-title: Ann. Stat.
– volume: 5
  start-page: 13
  issue: 1
  year: 2006
  ident: 10.1016/j.csda.2023.107862_br0080
  article-title: Pathogen detection, testing, and control in fresh broccoli sprouts
  publication-title: Nutr. J.
  doi: 10.1186/1475-2891-5-13
– volume: 31
  start-page: 3269
  issue: 27
  year: 2012
  ident: 10.1016/j.csda.2023.107862_br0130
  article-title: Use of pooled samples from the national health and nutrition examination survey
  publication-title: Stat. Med.
  doi: 10.1002/sim.5341
– volume: 40
  start-page: 3742
  issue: 12
  year: 2006
  ident: 10.1016/j.csda.2023.107862_br0100
  article-title: Levels of 12 perfluorinated chemicals in pooled Australian serum, collected 2002–2003, in relation to age, gender, and region
  publication-title: Environ. Sci. Technol.
  doi: 10.1021/es060301u
– volume: 43
  start-page: 2641
  issue: 7
  year: 2009
  ident: 10.1016/j.csda.2023.107862_br0120
  article-title: Polyfluoroalkyl compounds in pooled sera from children participating in the national health and nutrition examination survey 2001–2002
  publication-title: Environ. Sci. Technol.
  doi: 10.1021/es803156p
– volume: 40
  start-page: 131
  issue: 1
  year: 2012
  ident: 10.1016/j.csda.2023.107862_br0240
  article-title: Nonparametric regression with homogeneous group testing data
  publication-title: Ann. Stat.
  doi: 10.1214/11-AOS952
– volume: 55
  start-page: 757
  issue: 4
  year: 1993
  ident: 10.1016/j.csda.2023.107862_br0190
  article-title: Varying-coefficient models
  publication-title: J. R. Stat. Soc. Ser. B
  doi: 10.1111/j.2517-6161.1993.tb01939.x
– volume: 60
  start-page: 291
  issue: 2
  year: 2010
  ident: 10.1016/j.csda.2023.107862_br0290
  article-title: Effects of individual polybrominated diphenyl ether (pbde) congeners on harbour seal immune cells in vitro
  publication-title: Mar. Pollut. Bull.
  doi: 10.1016/j.marpolbul.2009.09.006
– volume: 38
  start-page: 2739
  issue: 12
  year: 2011
  ident: 10.1016/j.csda.2023.107862_br0140
  article-title: Cost-efficient designs based on linearly associated biomarkers
  publication-title: J. Appl. Stat.
  doi: 10.1080/02664763.2011.567254
– volume: 70
  start-page: 202
  issue: 1
  year: 2014
  ident: 10.1016/j.csda.2023.107862_br0150
  article-title: Regression for skewed biomarker outcomes subject to pooling
  publication-title: Biometrics
  doi: 10.1111/biom.12134
– volume: 58
  start-page: 943
  issue: 7
  year: 2005
  ident: 10.1016/j.csda.2023.107862_br0090
  article-title: Methodological aspects of a national population-based study of persistent organochlorine compounds in serum
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2004.08.095
– volume: 8
  start-page: 715
  issue: 4
  year: 1999
  ident: 10.1016/j.csda.2023.107862_br0310
  article-title: A root-n consistent backfitting estimator for semiparametric additive modeling
  publication-title: J. Comput. Graph. Stat.
– volume: 15
  start-page: 452
  issue: 4
  year: 2010
  ident: 10.1016/j.csda.2023.107862_br0070
  article-title: A Bayesian approach to estimate ojd prevalence from pooled fecal samples of variable pool size
  publication-title: J. Agric. Biol. Environ. Stat.
  doi: 10.1007/s13253-010-0032-8
– volume: 58
  start-page: 71
  issue: 1–2
  year: 1993
  ident: 10.1016/j.csda.2023.107862_br0180
  article-title: Semiparametric least squares (sls) and weighted sls estimation of single-index models
  publication-title: J. Econom.
  doi: 10.1016/0304-4076(93)90114-K
– year: 2021
  ident: 10.1016/j.csda.2023.107862_br0230
  article-title: Varying-coefficient regression analysis for pooled biomonitoring
  publication-title: Biometrics
– volume: 67
  start-page: 1036
  issue: 4
  year: 2000
  ident: 10.1016/j.csda.2023.107862_br0060
  article-title: The efficiency of pooling in the detection of rare mutations
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/303097
– volume: 30
  start-page: 813
  issue: 4
  year: 2018
  ident: 10.1016/j.csda.2023.107862_br0220
  article-title: Single-index regression for pooled biomarker data
  publication-title: J. Nonparametr. Stat.
  doi: 10.1080/10485252.2018.1483501
– volume: 82
  start-page: 371
  issue: 398
  year: 1987
  ident: 10.1016/j.csda.2023.107862_br0200
  article-title: Generalized additive models: some applications
  publication-title: J. Am. Stat. Assoc.
  doi: 10.1080/01621459.1987.10478440
– volume: 32
  start-page: 814
  issue: 4
  year: 2020
  ident: 10.1016/j.csda.2023.107862_br0170
  article-title: Local polynomial regression for pooled response data
  publication-title: J. Nonparametr. Stat.
  doi: 10.1080/10485252.2020.1834104
– year: 2000
  ident: 10.1016/j.csda.2023.107862_br0210
– volume: 10
  start-page: 1
  issue: 1
  year: 2020
  ident: 10.1016/j.csda.2023.107862_br0270
  article-title: Maternal transfer of environmentally relevant polybrominated diphenyl ethers (pbdes) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-74853-9
– volume: 36
  start-page: 2363
  issue: 15
  year: 2017
  ident: 10.1016/j.csda.2023.107862_br0160
  article-title: A general framework for the regression analysis of pooled biomarker assessments
  publication-title: Stat. Med.
  doi: 10.1002/sim.7291
SSID ssj0002478
Score 2.3940713
Snippet Human biomonitoring involves monitoring human health by measuring the accumulation of harmful chemicals, typically in specimens like blood samples. The high...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 107862
SubjectTerms Additive partially linear model
bioaccumulation
Biomarkers
blood
bromination
chemical analysis
cost effectiveness
data analysis
environmental health
environmental monitoring
Homogeneous pooling
human health
humans
linear models
Local linear fit
National Health and Nutrition Examination Survey
NHANES
Pooled biospecimens
risk
toxicity
Title Additive partially linear model for pooled biomonitoring data
URI https://dx.doi.org/10.1016/j.csda.2023.107862
https://www.ncbi.nlm.nih.gov/pubmed/38187953
https://www.proquest.com/docview/2911843149
https://www.proquest.com/docview/3153156476
https://pubmed.ncbi.nlm.nih.gov/PMC10769007
Volume 190
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB5V5VIOCFoeoVBtpd6QSex9HzhEFVVo1B6Ait5W3odFUORGTXrg0t_OjB8poWoP-GJ5vZZ2Z3ZnPu9-MwtwZPPK-FKpzAtB24zGZ7ZKeVaFWFGwrknNOuTZuZpciNNLebkFx30sDNEqO9vf2vTGWnclw06aw8VsNvxGBHorNEcQjcOqiaUWQtMo_3h7R_MoRGuNKb831e4CZ1qOV1hGyj1UcCzQRhUPOaf74PNfDuVfTunkOTzr0CQbtw1-AVup3oWnZ-tUrMs9-DSOseEHsQX1q5zPfzOCluU1a07BYYhaGR20lSKjWPxmjtNiHyPy6Eu4OPn8_XiSdWcmZEEYu8rw90EG9Eq-TKPKWh_LaJQsjUXPHystVKUKnfDKg8gj19LzMgUt_EhQxKDnr2C7vqrTG2CSXLnPteExCSlyH9CZyzxZMwocFTyAvBeWC11CcTrXYu565tgvRwJ2JGDXCngAH9bfLNp0Go_Wlr0O3MagcGjvH_3usFeYw9lCWyBlna5ulq5A224QMwn7cB2OToBS6Gg1gNetktdtJXyjreQDMBvqX1egbN2bb-rZzyZrNzZNWURkb_-zU_uwg0-iZYy_g-3V9U16j4Bo5Q-aEX8AT8ZfppNzuk-__pj-AeujC58
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxEB5V6QE4IN6Ep5G4oVWy6_eBQ1RRpbTJhVbqzVo_VqSKtlGTHvj3zOxLBNQe2KMfkj1jz3xrz3wG-GzzyvhSqcwLQdeMxme2SnlWhVhRsq5JzTnkYqnmF-L7pbw8gKM-F4bCKjvb39r0xlp3JZNOmpPNajX5QQH0VmiOIBqXFeVSHxI7lRzB4ezkdL4cDHIhWoNMFN_UocudacO8wjYS_VDBsUAbVdzln_7Fn3-HUf7hl46fwOMOULJZO-ancJDqZ_BoMbCxbp_D11mMTYgQ29DUyvX6FyN0Wd6w5iEchsCV0VtbKTJKx2-2OZ33MYoffQEXx9_Oj-ZZ92xCFoSxuwz_IGRAx-TLNK2s9bGMRsnSWHT-sdJCVarQCb88iDxyLT0vU9DCTwUlDXr-Ekb1dZ1eA5PkzX2uDY8JZZv7gP5c5smaaeCo4zHkvbBc6DjF6WmLteuDx64cCdiRgF0r4DF8GfpsWkaNe1vLXgdub104NPn39vvUK8zhhqFbkLJO17dbV6B5NwibhL27DUc_QCw6Wo3hVavkYawEcbSVfAxmT_1DAyLs3q-pVz8b4m4cmrIIyt7856Q-woP5-eLMnZ0sT9_CQ6wRbQD5Oxjtbm7Te8RHO_-hW_-_AasODK0
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Additive+partially+linear+model+for+pooled+biomonitoring+data&rft.jtitle=Computational+statistics+%26+data+analysis&rft.au=Mou%2C+Xichen&rft.au=Wang%2C+Dewei&rft.date=2024-02-01&rft.issn=0167-9473&rft.volume=190&rft.spage=107862&rft_id=info:doi/10.1016%2Fj.csda.2023.107862&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_csda_2023_107862
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-9473&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-9473&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-9473&client=summon